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The map label for this gene is ytcA [H]

Identifier: 138894394

GI number: 138894394

Start: 799884

End: 801167

Strand: Reverse

Name: ytcA [H]

Synonym: GTNG_0722

Alternate gene names: 138894394

Gene position: 801167-799884 (Counterclockwise)

Preceding gene: 138894395

Following gene: 138894393

Centisome position: 22.57

GC content: 53.74

Gene sequence:

>1284_bases
ATGAATATCTGCATCATCGGCGCTGGCTACGTCGGACTGACCACTGCAGCCGTCCTCGCTGAACTTGGGCATGAGGTGCA
TTGCATCGACCATGATGAACGGAAAATTCACCTGCTCAACAACGGAGAAGTTCCGTTTTATGAGCCGGGATTAGAAGAGT
TAATCACTAAAAATTGTAACTATTTAACATTTAGCGGCCGCTGGGATTATATTAAACGGGCGGCCGTCATTGTCATTTGC
GTCGGCACTCCGCCGCGGCCGGACGGCAGCGCCGACTTACGCTATATCGAAGCGGTGCTCGACCGTTTAGCCGCCACGAT
CGAATCGTACAAAACGATCGTCACAAAAAGCACTGTCCCTCCGGGGACGAATGAATGGATGCGCGCTGAACTCATCCGAA
AAGGAGTAGCCCCACATTTATTCCGCATCGTATCCAATCCGGAGTTTTTGCGCGAAGGGTCGGCTGTTTACGATATGTTT
CATCCGGACAAAATCGTTGTCGGCCTCGAGCCGGATGACGATCGGTCGCTTGCTGTCGTGCAGGCCATGTATGCCGGCAT
CAACGCTCCTTACGTCACGACAAGCCTCACCGGGGCGGAACTGATCAAATATGCCGCCAACGCCTTTTTAGCAACCAAAA
TATCCTTTATCAACGAAATGGCGCGCATTTGCGACGCATTTGCCGTCGATATCAACGACGTCGCCCGCGGGATTGGCTTC
GACCCGCGCATAGGACCGCATTTTTTGCAAGCTGGTCTCGGCTATGGAGGCTCCTGCTTCCCCAAGGATGTGAAAGCACT
CGAACATGCAGCGCGCTCGCGTGATGTCGAGCCCCGCTTGCTACAGGCAGTCCAATCTGTCAACGCCACTCAAATTGACG
TTTGTCTCAACAAACTGAATAAAGAGCTTGCTCCGTTGAACGGTAAAAAAATAGCCGTGCTTGGCATCGCCTTTAAGCCG
AATACAGACGATACTCGCTTTTCCCCCGCCGAAGCGCTCATCCGTCAGTTAAGTGGATCGGGCTGCACGGTCGCTGCCTA
CGATCCGAAGGCGACGCTAACGGCGCCGCTTGCCAATGTCATACAAGTACAATCGGTGCACGAAGCGATCCAAGACGCAG
ATGCCCTGATCATCGCCACCGACTGGGACGAATTTCGCACACTTGACTGGTCAGAAGTGAAAGCGGCAATGAACGGGACA
CTCGTCTTTGACGGACGAAATTGCTTAGATCGCCGCGCTGTCGAACAAAGCGGCTTGCGCTACGTGGGGGTGGGACGTCC
ATGA

Upstream 100 bases:

>100_bases
AGGCTGCTTTATTTCCGGCGTTTTAGGCGCTTGCCATAGCAAACAAAACTTGTCCGTTAATACGCTATAAAAGAAGATTT
CGTGAAGGAGGCCTATTAGC

Downstream 100 bases:

>100_bases
ACATTCTCGTCACTGGAGCGGCCGGATTTATCGGCTCTCATTTATGTGAAAAACTGCTCGAAAACGATCAACACCAAGTC
ATCGGCGTCGACGGCTTTAT

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNICIIGAGYVGLTTAAVLAELGHEVHCIDHDERKIHLLNNGEVPFYEPGLEELITKNCNYLTFSGRWDYIKRAAVIVIC
VGTPPRPDGSADLRYIEAVLDRLAATIESYKTIVTKSTVPPGTNEWMRAELIRKGVAPHLFRIVSNPEFLREGSAVYDMF
HPDKIVVGLEPDDDRSLAVVQAMYAGINAPYVTTSLTGAELIKYAANAFLATKISFINEMARICDAFAVDINDVARGIGF
DPRIGPHFLQAGLGYGGSCFPKDVKALEHAARSRDVEPRLLQAVQSVNATQIDVCLNKLNKELAPLNGKKIAVLGIAFKP
NTDDTRFSPAEALIRQLSGSGCTVAAYDPKATLTAPLANVIQVQSVHEAIQDADALIIATDWDEFRTLDWSEVKAAMNGT
LVFDGRNCLDRRAVEQSGLRYVGVGRP

Sequences:

>Translated_427_residues
MNICIIGAGYVGLTTAAVLAELGHEVHCIDHDERKIHLLNNGEVPFYEPGLEELITKNCNYLTFSGRWDYIKRAAVIVIC
VGTPPRPDGSADLRYIEAVLDRLAATIESYKTIVTKSTVPPGTNEWMRAELIRKGVAPHLFRIVSNPEFLREGSAVYDMF
HPDKIVVGLEPDDDRSLAVVQAMYAGINAPYVTTSLTGAELIKYAANAFLATKISFINEMARICDAFAVDINDVARGIGF
DPRIGPHFLQAGLGYGGSCFPKDVKALEHAARSRDVEPRLLQAVQSVNATQIDVCLNKLNKELAPLNGKKIAVLGIAFKP
NTDDTRFSPAEALIRQLSGSGCTVAAYDPKATLTAPLANVIQVQSVHEAIQDADALIIATDWDEFRTLDWSEVKAAMNGT
LVFDGRNCLDRRAVEQSGLRYVGVGRP
>Mature_427_residues
MNICIIGAGYVGLTTAAVLAELGHEVHCIDHDERKIHLLNNGEVPFYEPGLEELITKNCNYLTFSGRWDYIKRAAVIVIC
VGTPPRPDGSADLRYIEAVLDRLAATIESYKTIVTKSTVPPGTNEWMRAELIRKGVAPHLFRIVSNPEFLREGSAVYDMF
HPDKIVVGLEPDDDRSLAVVQAMYAGINAPYVTTSLTGAELIKYAANAFLATKISFINEMARICDAFAVDINDVARGIGF
DPRIGPHFLQAGLGYGGSCFPKDVKALEHAARSRDVEPRLLQAVQSVNATQIDVCLNKLNKELAPLNGKKIAVLGIAFKP
NTDDTRFSPAEALIRQLSGSGCTVAAYDPKATLTAPLANVIQVQSVHEAIQDADALIIATDWDEFRTLDWSEVKAAMNGT
LVFDGRNCLDRRAVEQSGLRYVGVGRP

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=442, Percent_Identity=35.972850678733, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI296040438, Length=345, Percent_Identity=35.3623188405797, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI296040443, Length=294, Percent_Identity=35.0340136054422, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=29.4943820224719, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI48994968, Length=410, Percent_Identity=26.3414634146341, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=35.3070175438597, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=34.9240780911063, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 46583; Mature: 46583

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNICIIGAGYVGLTTAAVLAELGHEVHCIDHDERKIHLLNNGEVPFYEPGLEELITKNCN
CEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCC
YLTFSGRWDYIKRAAVIVICVGTPPRPDGSADLRYIEAVLDRLAATIESYKTIVTKSTVP
EEEECCCHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PGTNEWMRAELIRKGVAPHLFRIVSNPEFLREGSAVYDMFHPDKIVVGLEPDDDRSLAVV
CCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCCEEEEECCCEEEEECCCCCCCHHHHH
QAMYAGINAPYVTTSLTGAELIKYAANAFLATKISFINEMARICDAFAVDINDVARGIGF
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
DPRIGPHFLQAGLGYGGSCFPKDVKALEHAARSRDVEPRLLQAVQSVNATQIDVCLNKLN
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHH
KELAPLNGKKIAVLGIAFKPNTDDTRFSPAEALIRQLSGSGCTVAAYDPKATLTAPLANV
HHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
IQVQSVHEAIQDADALIIATDWDEFRTLDWSEVKAAMNGTLVFDGRNCLDRRAVEQSGLR
HHHHHHHHHHHCCCEEEEEECHHHHHCCCHHHHHHHHCCEEEECCCHHHHHHHHHHCCCE
YVGVGRP
EEECCCC
>Mature Secondary Structure
MNICIIGAGYVGLTTAAVLAELGHEVHCIDHDERKIHLLNNGEVPFYEPGLEELITKNCN
CEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCC
YLTFSGRWDYIKRAAVIVICVGTPPRPDGSADLRYIEAVLDRLAATIESYKTIVTKSTVP
EEEECCCHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PGTNEWMRAELIRKGVAPHLFRIVSNPEFLREGSAVYDMFHPDKIVVGLEPDDDRSLAVV
CCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCCEEEEECCCEEEEECCCCCCCHHHHH
QAMYAGINAPYVTTSLTGAELIKYAANAFLATKISFINEMARICDAFAVDINDVARGIGF
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
DPRIGPHFLQAGLGYGGSCFPKDVKALEHAARSRDVEPRLLQAVQSVNATQIDVCLNKLN
CCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHH
KELAPLNGKKIAVLGIAFKPNTDDTRFSPAEALIRQLSGSGCTVAAYDPKATLTAPLANV
HHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
IQVQSVHEAIQDADALIIATDWDEFRTLDWSEVKAAMNGTLVFDGRNCLDRRAVEQSGLR
HHHHHHHHHHHCCCEEEEEECHHHHHCCCHHHHHHHHCCEEEECCCHHHHHHHHHHCCCE
YVGVGRP
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]