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The map label for this gene is cls [H]

Identifier: 138894372

GI number: 138894372

Start: 778931

End: 780439

Strand: Direct

Name: cls [H]

Synonym: GTNG_0700

Alternate gene names: 138894372

Gene position: 778931-780439 (Clockwise)

Preceding gene: 138894371

Following gene: 138894373

Centisome position: 21.94

GC content: 48.77

Gene sequence:

>1509_bases
TTGAGAAACACATCTAGAGTGGCGATTCTCATCGTCATTGTCGGTGTACTGCTGACATTGACGCACGATTATTGGGGAGG
AAAGCTGCTTGGCATTTTTAGTGTGCTCATCTCTTGTTCAGTGGTATTTATCGCATTTGTCATTTCACTCGAGAATCGAA
AACCAGCGCAAACGATCGCTTGGCTGGCAGTGTTAGGCAGCTTTCCGTTTCTTGGATTTTTATTTTATTTATTGTTTGGG
CGTAACTATTGGCAACAGCGGCGCTTTAAAAAGAAAGCTGAATCTGATGAAGCAGTGTTGCTGAAGTTTCAAGAGCCGTC
GCCGATCGCCATAGAGCGGCTGCCGATGGCACCCCATCAGCGCCCGTTGTTGCATCTTGCCTATCGCATCGGCCAACATC
CAGTTTCATTGGCGTCACAAACGGCGGTGTTGACGAACGGCGAAGAGACGTTTGCCGCGATTTTTGACGAGTTGGAAAAA
GCACAGCACCATATTCATTTGGAATACTATATCGTCCGTCATGACGAAATCGGTCAAAAACTGAAACATGTCCTGATGGA
AAAGGCGTGCCAAGGTGTGCATGTTCGCTTTTTGTATGACGCTGTCGGAAGCTGGAAGCTGTCGAACGCATACATTGAAG
AGCTGCGTGCAGCTGGGGTGGAGATGATTCCGTTTTCACCGGTGCGTCTGCCCTTTTTGAGCAACCAAATCAACTTCCGC
AACCACCGAAAAATTATTGTCATCGACGGAGGCGTCGGCTTTGTCGGCGGGCTGAACATCGGTGATGAATATTTGGGAAA
AGACGAATATTTTGGGTTTTGGCGTGATACCCATTTGTTGATTCGAGGCGAGGCTGTTCGGACGCTGCAACTTATTTTCT
TGCAAGACTGGTATTATATGACGGGAGAGCGATTGTTGACGCCGGAATATTTATCACCACCGCTCATTGTCGAGGAAGGC
CAGGGCGGGGTGCAGCTCATTGCCGGCGGGCCGGATCAAAAGTGGGAAGTGATTAAACAGTTGTATTTTGCCATGATTAC
GTCAGCGAAACGGTCGATTTGGGTCGCCTCGCCGTACTTTGTTCCGGATGAAGACATTTTAACGGCGCTGAAAGTGGCGG
CACTAAGTGGCATCGACGTCCGCCTGCTGGCACCGAAGCGCCCGGACAAAAAAATCGTCTTTTACGCCTCGCGCTCGTAC
TTCCCAGAACTGTTGGAAGCCGGAGTGAAAATTTACGAGTACGAAAAAGGGTTTTTGCACAGCAAGGTGATCGTCGTCGA
TGGAGAGCTTGCCTCGATTGGCACGGCAAACATGGATATGCGCAGCTTTCATTTAAACTTTGAAGTGAACGCGTTTTTGT
ATTATACGGACAGCACAAACAAACTTGTGAACGATTTTTTGGAAGATTTCCGTCATGCTTCCCCAATTGATTATGTACAG
TTCCAGCAGCGCCCATTCCGGGTGCGGATTGTTGAATCGGTTTCGCGCCTGCTGTCGCCGCTATTGTAA

Upstream 100 bases:

>100_bases
ATAACGTCTCCATGCCGCCGATTTCGCTGCCAGAAATCGGCGTTTTCTTCGTTAATGAAGGGAAGGGTAGCCATCATGAA
AAGCAGGTGGAGGGGTTTCG

Downstream 100 bases:

>100_bases
CGATATGTTTTGAGTGCTTGAGATGCAAGTCCGCCGGCTTGGCGGGCTTTTTTTATTGGCCTGTTCCCCATCGGCAGGAA
AAACGTGGACGTTTGCCGAA

Product: cardiolipin synthetase

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRNTSRVAILIVIVGVLLTLTHDYWGGKLLGIFSVLISCSVVFIAFVISLENRKPAQTIAWLAVLGSFPFLGFLFYLLFG
RNYWQQRRFKKKAESDEAVLLKFQEPSPIAIERLPMAPHQRPLLHLAYRIGQHPVSLASQTAVLTNGEETFAAIFDELEK
AQHHIHLEYYIVRHDEIGQKLKHVLMEKACQGVHVRFLYDAVGSWKLSNAYIEELRAAGVEMIPFSPVRLPFLSNQINFR
NHRKIIVIDGGVGFVGGLNIGDEYLGKDEYFGFWRDTHLLIRGEAVRTLQLIFLQDWYYMTGERLLTPEYLSPPLIVEEG
QGGVQLIAGGPDQKWEVIKQLYFAMITSAKRSIWVASPYFVPDEDILTALKVAALSGIDVRLLAPKRPDKKIVFYASRSY
FPELLEAGVKIYEYEKGFLHSKVIVVDGELASIGTANMDMRSFHLNFEVNAFLYYTDSTNKLVNDFLEDFRHASPIDYVQ
FQQRPFRVRIVESVSRLLSPLL

Sequences:

>Translated_502_residues
MRNTSRVAILIVIVGVLLTLTHDYWGGKLLGIFSVLISCSVVFIAFVISLENRKPAQTIAWLAVLGSFPFLGFLFYLLFG
RNYWQQRRFKKKAESDEAVLLKFQEPSPIAIERLPMAPHQRPLLHLAYRIGQHPVSLASQTAVLTNGEETFAAIFDELEK
AQHHIHLEYYIVRHDEIGQKLKHVLMEKACQGVHVRFLYDAVGSWKLSNAYIEELRAAGVEMIPFSPVRLPFLSNQINFR
NHRKIIVIDGGVGFVGGLNIGDEYLGKDEYFGFWRDTHLLIRGEAVRTLQLIFLQDWYYMTGERLLTPEYLSPPLIVEEG
QGGVQLIAGGPDQKWEVIKQLYFAMITSAKRSIWVASPYFVPDEDILTALKVAALSGIDVRLLAPKRPDKKIVFYASRSY
FPELLEAGVKIYEYEKGFLHSKVIVVDGELASIGTANMDMRSFHLNFEVNAFLYYTDSTNKLVNDFLEDFRHASPIDYVQ
FQQRPFRVRIVESVSRLLSPLL
>Mature_502_residues
MRNTSRVAILIVIVGVLLTLTHDYWGGKLLGIFSVLISCSVVFIAFVISLENRKPAQTIAWLAVLGSFPFLGFLFYLLFG
RNYWQQRRFKKKAESDEAVLLKFQEPSPIAIERLPMAPHQRPLLHLAYRIGQHPVSLASQTAVLTNGEETFAAIFDELEK
AQHHIHLEYYIVRHDEIGQKLKHVLMEKACQGVHVRFLYDAVGSWKLSNAYIEELRAAGVEMIPFSPVRLPFLSNQINFR
NHRKIIVIDGGVGFVGGLNIGDEYLGKDEYFGFWRDTHLLIRGEAVRTLQLIFLQDWYYMTGERLLTPEYLSPPLIVEEG
QGGVQLIAGGPDQKWEVIKQLYFAMITSAKRSIWVASPYFVPDEDILTALKVAALSGIDVRLLAPKRPDKKIVFYASRSY
FPELLEAGVKIYEYEKGFLHSKVIVVDGELASIGTANMDMRSFHLNFEVNAFLYYTDSTNKLVNDFLEDFRHASPIDYVQ
FQQRPFRVRIVESVSRLLSPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=470, Percent_Identity=30, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787007, Length=320, Percent_Identity=30.625, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081826, Length=386, Percent_Identity=25.1295336787565, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 57336; Mature: 57336

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTSRVAILIVIVGVLLTLTHDYWGGKLLGIFSVLISCSVVFIAFVISLENRKPAQTIA
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
WLAVLGSFPFLGFLFYLLFGRNYWQQRRFKKKAESDEAVLLKFQEPSPIAIERLPMAPHQ
HHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCC
RPLLHLAYRIGQHPVSLASQTAVLTNGEETFAAIFDELEKAQHHIHLEYYIVRHDEIGQK
CHHHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHHHHHHEEEEEEEEEECHHHHHH
LKHVLMEKACQGVHVRFLYDAVGSWKLSNAYIEELRAAGVEMIPFSPVRLPFLSNQINFR
HHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHHHHHHCCEEECCCCCEECCCCCCCCCCC
NHRKIIVIDGGVGFVGGLNIGDEYLGKDEYFGFWRDTHLLIRGEAVRTLQLIFLQDWYYM
CCCEEEEEECCCCEEECCCCCHHHCCCCCCCEEEECEEEEEECCHHHHEEEEEEHHHHEE
TGERLLTPEYLSPPLIVEEGQGGVQLIAGGPDQKWEVIKQLYFAMITSAKRSIWVASPYF
CCCEEECHHHCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
VPDEDILTALKVAALSGIDVRLLAPKRPDKKIVFYASRSYFPELLEAGVKIYEYEKGFLH
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCHHHHHHCCCEEEEECCCCCE
SKVIVVDGELASIGTANMDMRSFHLNFEVNAFLYYTDSTNKLVNDFLEDFRHASPIDYVQ
EEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHH
FQQRPFRVRIVESVSRLLSPLL
HCCCCCEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNTSRVAILIVIVGVLLTLTHDYWGGKLLGIFSVLISCSVVFIAFVISLENRKPAQTIA
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
WLAVLGSFPFLGFLFYLLFGRNYWQQRRFKKKAESDEAVLLKFQEPSPIAIERLPMAPHQ
HHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCC
RPLLHLAYRIGQHPVSLASQTAVLTNGEETFAAIFDELEKAQHHIHLEYYIVRHDEIGQK
CHHHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHHHHHHEEEEEEEEEECHHHHHH
LKHVLMEKACQGVHVRFLYDAVGSWKLSNAYIEELRAAGVEMIPFSPVRLPFLSNQINFR
HHHHHHHHHHCCCEEEEEECCCCCCEEHHHHHHHHHHCCEEECCCCCEECCCCCCCCCCC
NHRKIIVIDGGVGFVGGLNIGDEYLGKDEYFGFWRDTHLLIRGEAVRTLQLIFLQDWYYM
CCCEEEEEECCCCEEECCCCCHHHCCCCCCCEEEECEEEEEECCHHHHEEEEEEHHHHEE
TGERLLTPEYLSPPLIVEEGQGGVQLIAGGPDQKWEVIKQLYFAMITSAKRSIWVASPYF
CCCEEECHHHCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
VPDEDILTALKVAALSGIDVRLLAPKRPDKKIVFYASRSYFPELLEAGVKIYEYEKGFLH
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCHHHHHHCCCEEEEECCCCCE
SKVIVVDGELASIGTANMDMRSFHLNFEVNAFLYYTDSTNKLVNDFLEDFRHASPIDYVQ
EEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHH
FQQRPFRVRIVESVSRLLSPLL
HCCCCCEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA