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The map label for this gene is yisK [H]

Identifier: 138894277

GI number: 138894277

Start: 666507

End: 667415

Strand: Direct

Name: yisK [H]

Synonym: GTNG_0603

Alternate gene names: 138894277

Gene position: 666507-667415 (Clockwise)

Preceding gene: 138894275

Following gene: 138894278

Centisome position: 18.77

GC content: 52.26

Gene sequence:

>909_bases
GTGAAACTAATTACGGCTATTTTCAATGGAGGAGAACCAGCAATCGGAGTGGTGCCGGAAGGGGAGGAGACGGCTATTCA
TTTGCGCCGTGCTGAACGGGCGATGGACGGGAAGGAGACCATTCCGTCATCCATGCTAGAGGCCATCGCCCAAGGGGATG
CTTTTTTGGCTCGAGCTCGGGAAGTTGCCGATTGGGCTCTTCGCTACTCGGGAGCGAACTACGTCTATCGCCTTGGTGAT
ATTCGCCTCCTTGCCCCGATTCCGCGGCCGGCGAAAAACGTTTTTTGCATCGGCAAAAACTATGTTGACCATGCGCTTGA
GCTGGGAGATGCCGCTGATGTACCGAAGCATTTAATCGTCTTCTCGAAAACGCCGACGACGGTCATTGGCCATGAGGAAA
CGATTTTGCGCCATGCGGATGTCACTGACGAAGTGGACTATGAAGGGGAGCTCGCATTGATCATTGGTAAAAAAGGGCAG
GCGATTCGCCGCGAAGAAGCGCTCGATTACGTATTTGGATACACGATTATCAATGATGTGACCGCCCGTGATTTGCAGGA
GCGACACCAACAATATTTGCTCGGCAAAAGCTTGGACACGTTCTGTCCGATGGGGCCATGGATCGTGCCAAGCAAATTTG
TAACAAATCCGAACGATTTACGCATTGAAACGCGAGTGAACGGCGAAGTACGGCAGCAGGCGAGCACAAAACAGTTTATT
TTTCCGATTGAATCGATCATTGAGACGATCTCAAAAGGCATGACGCTTGAACCGGGCGATATTATTGCTACAGGAACGCC
GGCTGGGGTCGGCAAAGGAATGAATCCGCCGCGCTTTTTGCAAGCAGGTGATGTCGTCGAAGTGACCATCGAGGGAATCG
GCACGCTGCGCAACAAAGTCGGGGAATGA

Upstream 100 bases:

>100_bases
AATAGCGAATAGAATAGTCAATGCGCTGCGATGGGGGGATGCAGTCTGTATGCCTGCTCCCGTGCATTTGAACACTTAGG
TAGAGAAGGAGAGGAAGACA

Downstream 100 bases:

>100_bases
GCTAAGCACAAACAGAGATAGCATGCCGCCGAAAAGGGTTATCAAAAATAGAGGAGTTTTTCATCTTTCGTAATGTTTGT
CAACAGCTTGCCGCCCATGC

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKLITAIFNGGEPAIGVVPEGEETAIHLRRAERAMDGKETIPSSMLEAIAQGDAFLARAREVADWALRYSGANYVYRLGD
IRLLAPIPRPAKNVFCIGKNYVDHALELGDAADVPKHLIVFSKTPTTVIGHEETILRHADVTDEVDYEGELALIIGKKGQ
AIRREEALDYVFGYTIINDVTARDLQERHQQYLLGKSLDTFCPMGPWIVPSKFVTNPNDLRIETRVNGEVRQQASTKQFI
FPIESIIETISKGMTLEPGDIIATGTPAGVGKGMNPPRFLQAGDVVEVTIEGIGTLRNKVGE

Sequences:

>Translated_302_residues
MKLITAIFNGGEPAIGVVPEGEETAIHLRRAERAMDGKETIPSSMLEAIAQGDAFLARAREVADWALRYSGANYVYRLGD
IRLLAPIPRPAKNVFCIGKNYVDHALELGDAADVPKHLIVFSKTPTTVIGHEETILRHADVTDEVDYEGELALIIGKKGQ
AIRREEALDYVFGYTIINDVTARDLQERHQQYLLGKSLDTFCPMGPWIVPSKFVTNPNDLRIETRVNGEVRQQASTKQFI
FPIESIIETISKGMTLEPGDIIATGTPAGVGKGMNPPRFLQAGDVVEVTIEGIGTLRNKVGE
>Mature_302_residues
MKLITAIFNGGEPAIGVVPEGEETAIHLRRAERAMDGKETIPSSMLEAIAQGDAFLARAREVADWALRYSGANYVYRLGD
IRLLAPIPRPAKNVFCIGKNYVDHALELGDAADVPKHLIVFSKTPTTVIGHEETILRHADVTDEVDYEGELALIIGKKGQ
AIRREEALDYVFGYTIINDVTARDLQERHQQYLLGKSLDTFCPMGPWIVPSKFVTNPNDLRIETRVNGEVRQQASTKQFI
FPIESIIETISKGMTLEPGDIIATGTPAGVGKGMNPPRFLQAGDVVEVTIEGIGTLRNKVGE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=264, Percent_Identity=43.5606060606061, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI40786394, Length=264, Percent_Identity=42.4242424242424, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI13654274, Length=213, Percent_Identity=36.6197183098592, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI66348062, Length=206, Percent_Identity=36.8932038834951, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI215422413, Length=206, Percent_Identity=36.8932038834951, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1787428, Length=207, Percent_Identity=33.8164251207729, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17557057, Length=208, Percent_Identity=37.5, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324161, Length=236, Percent_Identity=30.5084745762712, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28572127, Length=266, Percent_Identity=39.4736842105263, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24663695, Length=221, Percent_Identity=38.9140271493213, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28571789, Length=213, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 33150; Mature: 33150

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLITAIFNGGEPAIGVVPEGEETAIHLRRAERAMDGKETIPSSMLEAIAQGDAFLARAR
CEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCHHHHHHHH
EVADWALRYSGANYVYRLGDIRLLAPIPRPAKNVFCIGKNYVDHALELGDAADVPKHLIV
HHHHHHHHCCCCCEEEEECCEEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCCCCEEEE
FSKTPTTVIGHEETILRHADVTDEVDYEGELALIIGKKGQAIRREEALDYVFGYTIINDV
EECCCCEEECCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
TARDLQERHQQYLLGKSLDTFCPMGPWIVPSKFVTNPNDLRIETRVNGEVRQQASTKQFI
HHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHEE
FPIESIIETISKGMTLEPGDIIATGTPAGVGKGMNPPRFLQAGDVVEVTIEGIGTLRNKV
ECHHHHHHHHHCCCEECCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
GE
CC
>Mature Secondary Structure
MKLITAIFNGGEPAIGVVPEGEETAIHLRRAERAMDGKETIPSSMLEAIAQGDAFLARAR
CEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHCCHHHHHHHH
EVADWALRYSGANYVYRLGDIRLLAPIPRPAKNVFCIGKNYVDHALELGDAADVPKHLIV
HHHHHHHHCCCCCEEEEECCEEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCCCCEEEE
FSKTPTTVIGHEETILRHADVTDEVDYEGELALIIGKKGQAIRREEALDYVFGYTIINDV
EECCCCEEECCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
TARDLQERHQQYLLGKSLDTFCPMGPWIVPSKFVTNPNDLRIETRVNGEVRQQASTKQFI
HHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHEE
FPIESIIETISKGMTLEPGDIIATGTPAGVGKGMNPPRFLQAGDVVEVTIEGIGTLRNKV
ECHHHHHHHHHCCCEECCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
GE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]