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The map label for this gene is moeB [H]

Identifier: 138894213

GI number: 138894213

Start: 600731

End: 601756

Strand: Direct

Name: moeB [H]

Synonym: GTNG_0539

Alternate gene names: 138894213

Gene position: 600731-601756 (Clockwise)

Preceding gene: 138894212

Following gene: 138894214

Centisome position: 16.92

GC content: 52.53

Gene sequence:

>1026_bases
TTGAACGAACGATATTCCCGACAGCAATTGTTTGCCCCAATCGGTGAGGCAGGACAAAAGAAAATACGGGAAAAGCATGT
TGTCTTAATCGGCGCTGGAGCGCTTGGCACGGGCAATGCTGAAGCGCTCGTACGCGCTGGGATTGGCAAATTGACGATCA
TTGACCGCGACTACGTCGAATGGAGCAATTTACAGCGCCAGCAGTTATACAGCGAAGCGGATGCGAAAGAGCGGCTGCCA
AAGGCGATCGCTGCCAAGCGACGTCTCGAACAAGTAAACAGTGATGTCCAGATTGAGGCCATTGTCGGGGATGCCGGTCC
AGAGGAGTTGGAGGCGCTTGTGGCTGAGCAGCGCCCCCATTTACTGATTGATGCAACCGACAATTTTGACGCGCGCATGG
TCATCAATGATGTCGCCTATAAATACAGCATTCCGTGGATCTACGGTGCCTGTGTCGGCAGCTACGGCTTAAGCTACGCC
TTTATCCCCGGGCGCACACCGTGCCTATACTGCCTGCTAGAAACGGTGCCGCAAGGGGGCTTGACGTGCGACACGGCCGG
TATTATTAGCCCGACGGTGCAAATGGTTGTTAGTTACCAGACGGCAGAAGCGTTGAAAATTTTAGTCGAAGACAGGGAGG
CGTTACGCGGCAAGCTCGTCTCGTTTGATCTTTGGACGAACGAATATGCGGCCATTCGCATTGATGCAGTGAAAAGAGAT
AATTGTCCGACGTGCGGTCATGATCCGTCCTATCCGTTTCTTTCTTATGAACAGCAGACGAAGACGGCCGTGTTGTGTGG
GCGTGATTCCGTGCAAATTCGCCCGTCTGCCCGTCGGCAATACGATTTAAATGAACTGGCAGCGTTATTTCGACGTCAAG
GGCTTCAAGCTGAAGCAAACCCATATCTCGTCTCTGTTTCGATCGGCGGCAAGAGGCTCGTCGTATTTGGTGACGGCCGT
GCACTTGTGCACGGTACAAAAGACGTGCAAGAGGCGAAAACGATTTATTACCGGTATTTAGGGTAA

Upstream 100 bases:

>100_bases
AGCTGGCGATTGAAGCGGGCCGACTTGGCTATGAAGCCGGGCGTATCCCGAAAAAGCGCTATGCGTCAGCGAGCAGCCCG
ATGGAAGGAATGAGTGTTGT

Downstream 100 bases:

>100_bases
AACCGTTGAGCATGAAGGGAGCATCTCTCGAACATACGGAATGGGGGCGTCCGTGTCAAGGGGCGTCCCTCTCTTTTAGC
TGTCACGAAACTGTCAAAAA

Product: thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNERYSRQQLFAPIGEAGQKKIREKHVVLIGAGALGTGNAEALVRAGIGKLTIIDRDYVEWSNLQRQQLYSEADAKERLP
KAIAAKRRLEQVNSDVQIEAIVGDAGPEELEALVAEQRPHLLIDATDNFDARMVINDVAYKYSIPWIYGACVGSYGLSYA
FIPGRTPCLYCLLETVPQGGLTCDTAGIISPTVQMVVSYQTAEALKILVEDREALRGKLVSFDLWTNEYAAIRIDAVKRD
NCPTCGHDPSYPFLSYEQQTKTAVLCGRDSVQIRPSARRQYDLNELAALFRRQGLQAEANPYLVSVSIGGKRLVVFGDGR
ALVHGTKDVQEAKTIYYRYLG

Sequences:

>Translated_341_residues
MNERYSRQQLFAPIGEAGQKKIREKHVVLIGAGALGTGNAEALVRAGIGKLTIIDRDYVEWSNLQRQQLYSEADAKERLP
KAIAAKRRLEQVNSDVQIEAIVGDAGPEELEALVAEQRPHLLIDATDNFDARMVINDVAYKYSIPWIYGACVGSYGLSYA
FIPGRTPCLYCLLETVPQGGLTCDTAGIISPTVQMVVSYQTAEALKILVEDREALRGKLVSFDLWTNEYAAIRIDAVKRD
NCPTCGHDPSYPFLSYEQQTKTAVLCGRDSVQIRPSARRQYDLNELAALFRRQGLQAEANPYLVSVSIGGKRLVVFGDGR
ALVHGTKDVQEAKTIYYRYLG
>Mature_341_residues
MNERYSRQQLFAPIGEAGQKKIREKHVVLIGAGALGTGNAEALVRAGIGKLTIIDRDYVEWSNLQRQQLYSEADAKERLP
KAIAAKRRLEQVNSDVQIEAIVGDAGPEELEALVAEQRPHLLIDATDNFDARMVINDVAYKYSIPWIYGACVGSYGLSYA
FIPGRTPCLYCLLETVPQGGLTCDTAGIISPTVQMVVSYQTAEALKILVEDREALRGKLVSFDLWTNEYAAIRIDAVKRD
NCPTCGHDPSYPFLSYEQQTKTAVLCGRDSVQIRPSARRQYDLNELAALFRRQGLQAEANPYLVSVSIGGKRLVVFGDGR
ALVHGTKDVQEAKTIYYRYLG

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=257, Percent_Identity=29.5719844357977, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI38045948, Length=179, Percent_Identity=29.608938547486, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=31.4285714285714, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082356, Length=251, Percent_Identity=35.0597609561753, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=33.0677290836653, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320598, Length=190, Percent_Identity=27.8947368421053, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321903, Length=211, Percent_Identity=27.9620853080569, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=29.4354838709677, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 37809; Mature: 37809

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERYSRQQLFAPIGEAGQKKIREKHVVLIGAGALGTGNAEALVRAGIGKLTIIDRDYVE
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCEEEEEECCCHH
WSNLQRQQLYSEADAKERLPKAIAAKRRLEQVNSDVQIEAIVGDAGPEELEALVAEQRPH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCC
LLIDATDNFDARMVINDVAYKYSIPWIYGACVGSYGLSYAFIPGRTPCLYCLLETVPQGG
EEEECCCCCCCEEEEEEHEEEEECCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCC
LTCDTAGIISPTVQMVVSYQTAEALKILVEDREALRGKLVSFDLWTNEYAAIRIDAVKRD
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEEEECC
NCPTCGHDPSYPFLSYEQQTKTAVLCGRDSVQIRPSARRQYDLNELAALFRRQGLQAEAN
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
PYLVSVSIGGKRLVVFGDGRALVHGTKDVQEAKTIYYRYLG
CEEEEEEECCEEEEEEECCEEEEECCHHHHHHHHEEEEECC
>Mature Secondary Structure
MNERYSRQQLFAPIGEAGQKKIREKHVVLIGAGALGTGNAEALVRAGIGKLTIIDRDYVE
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCEEEEEECCCHH
WSNLQRQQLYSEADAKERLPKAIAAKRRLEQVNSDVQIEAIVGDAGPEELEALVAEQRPH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCC
LLIDATDNFDARMVINDVAYKYSIPWIYGACVGSYGLSYAFIPGRTPCLYCLLETVPQGG
EEEECCCCCCCEEEEEEHEEEEECCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCC
LTCDTAGIISPTVQMVVSYQTAEALKILVEDREALRGKLVSFDLWTNEYAAIRIDAVKRD
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEEEEECC
NCPTCGHDPSYPFLSYEQQTKTAVLCGRDSVQIRPSARRQYDLNELAALFRRQGLQAEAN
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCC
PYLVSVSIGGKRLVVFGDGRALVHGTKDVQEAKTIYYRYLG
CEEEEEEECCEEEEEEECCEEEEECCHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]