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The map label for this gene is dctS [H]

Identifier: 138894176

GI number: 138894176

Start: 564809

End: 566386

Strand: Reverse

Name: dctS [H]

Synonym: GTNG_0502

Alternate gene names: 138894176

Gene position: 566386-564809 (Counterclockwise)

Preceding gene: 138894182

Following gene: 138894175

Centisome position: 15.95

GC content: 47.02

Gene sequence:

>1578_bases
ATGAATCGACTGCCGATCCGTTGGAAAATTACGATTTTAATTTTTGTTATCGTCAGCTTTTCGATGCTGCTGAGTGGTGT
TTTTATTATAAGCGACTTTTTCCATACAAAGGAAGAAGAGTTAAGCCAACGCGCCCTATTGACAGCGCGCACCGTATCCG
AACTGCCGGAAGTCAAGCAGCACATTGTCGGGCCAAAGGAAAACCGGGCGCTCGTAAACCCGATCGTCGAACGGGTACGC
ATCATCCATAGCGCTGATTATATTGTTGTGCTCGATATGAACAAAATTCGTCTCTCTCATCCGCTTCCATCAATGATTGG
CACCGTCTCCCGCGGGGCTGATGAAGGGCCGGCGTTCGCGGAACATACATACACATCAAAAGCACGTGGAGAAATCGGGA
CAGTAGTTCGCGCCTTCGTCCCTATTATGAATCGCCACCATGAACAGATTGGCGTCGTCATCGCCGCCTACCGATTGCCA
ACGTTTTTAGAAGCAATTGATACGCTAAAAGAAGAAATCGCCATGGCCGTTATTTTGTCGTTGCTCGCTGGTGGAAGTGG
AGCTTGGCTGCTCGCCTCTCATATTAAGCGGCAAATGTTTGAACTAGAACCGCATGAAATTGCCAAACTGCTTGTTGAGC
GAACAGAGGCGTTTAACGCTATGCACGAAGGCGTCATCGCCATCGACAGCAATGAAAATATTACTATTTTTAACGATCGG
GCGAAACAAATGCTTGGTATCGAAGGGGATGTGATTGGGCAGCCCATCCGTTCTGTCATTCCGGATACGTATCTTCCCGA
AATATTGAAAGTGAACAAGCCGATTTATAACAAAGAGCTGCAGCTTGGCAATTTAACGATCTGGAGCAATCGCATCCCGA
TTAAAGTCAATGGGAAAACCGTTGGTGCAATCGGCATTTTCCAAGATCGCACAGAAGTGAAACGGCTGGCTGAAGAACTA
ACGGGGGTAAAAGCGTTTGTCCATGCCTTGCGTGTGCAAAACCATGAATACATGAATAAGCTCCATACGATTGCCGGACT
GATCCAGCTTGGCCATATTGAGAAGGCGCTTGAATACGTGTTTCAAGTTACAGAAGAGCAGGAGGAACTCACGCAGTTTT
TAAGCCGCAACATCAAGGACGAAAGCATTTCAGGGTTATTGTTAAGCAAAATCCGCCGCGGCAAAGAGCTTGGCATTCTT
GTGACGATCGACCGGCACAGCCACCTTTATCGTTTTCCGCCGCGCCTCGACCACCATGATTTCGTCGTTCTCCTTGGCAA
CTTAATTGAAAACGCCTTCGATGCGTTCCAAGGGGTAACCGGTCGGGAAAAAGAAATTTACGTTAGTATTGAACAAAATG
AAGACATTTGCTCCCTCTCAATCGAAGATAACGGCCAAGGCATCGCTCGCGAGCATATCGATCGCATTTTTGACGAAGGC
TTTTCAACAAAAGGACAAAACGGGCGCGGCATCGGCCTATATTTAGTGAAGCAAATTGTGGAAAAAGGAAACGGTCACAT
CGATGTTCAGTCTGAGGAAGGGAAAGGGACCGTATTTACCATTACATTTGATATGTAA

Upstream 100 bases:

>100_bases
CACCGTTTTCGTCCATCGTTTTCTTCTTTTTTATCATATCACCGGAATCATGTTAGAATAAATAATAATGAATTTTCTGC
CTAAACAGAGGAGTTCACCG

Downstream 100 bases:

>100_bases
CCTTATTCATACAGTGGCAGCCGCATTCGACAAGCCCCTGCCCCAAGCCAAAGGAGGGAAAGACAATGTACCGTGTATTG
CTCATTGAAGATGACCCAAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNRLPIRWKITILIFVIVSFSMLLSGVFIISDFFHTKEEELSQRALLTARTVSELPEVKQHIVGPKENRALVNPIVERVR
IIHSADYIVVLDMNKIRLSHPLPSMIGTVSRGADEGPAFAEHTYTSKARGEIGTVVRAFVPIMNRHHEQIGVVIAAYRLP
TFLEAIDTLKEEIAMAVILSLLAGGSGAWLLASHIKRQMFELEPHEIAKLLVERTEAFNAMHEGVIAIDSNENITIFNDR
AKQMLGIEGDVIGQPIRSVIPDTYLPEILKVNKPIYNKELQLGNLTIWSNRIPIKVNGKTVGAIGIFQDRTEVKRLAEEL
TGVKAFVHALRVQNHEYMNKLHTIAGLIQLGHIEKALEYVFQVTEEQEELTQFLSRNIKDESISGLLLSKIRRGKELGIL
VTIDRHSHLYRFPPRLDHHDFVVLLGNLIENAFDAFQGVTGREKEIYVSIEQNEDICSLSIEDNGQGIAREHIDRIFDEG
FSTKGQNGRGIGLYLVKQIVEKGNGHIDVQSEEGKGTVFTITFDM

Sequences:

>Translated_525_residues
MNRLPIRWKITILIFVIVSFSMLLSGVFIISDFFHTKEEELSQRALLTARTVSELPEVKQHIVGPKENRALVNPIVERVR
IIHSADYIVVLDMNKIRLSHPLPSMIGTVSRGADEGPAFAEHTYTSKARGEIGTVVRAFVPIMNRHHEQIGVVIAAYRLP
TFLEAIDTLKEEIAMAVILSLLAGGSGAWLLASHIKRQMFELEPHEIAKLLVERTEAFNAMHEGVIAIDSNENITIFNDR
AKQMLGIEGDVIGQPIRSVIPDTYLPEILKVNKPIYNKELQLGNLTIWSNRIPIKVNGKTVGAIGIFQDRTEVKRLAEEL
TGVKAFVHALRVQNHEYMNKLHTIAGLIQLGHIEKALEYVFQVTEEQEELTQFLSRNIKDESISGLLLSKIRRGKELGIL
VTIDRHSHLYRFPPRLDHHDFVVLLGNLIENAFDAFQGVTGREKEIYVSIEQNEDICSLSIEDNGQGIAREHIDRIFDEG
FSTKGQNGRGIGLYLVKQIVEKGNGHIDVQSEEGKGTVFTITFDM
>Mature_525_residues
MNRLPIRWKITILIFVIVSFSMLLSGVFIISDFFHTKEEELSQRALLTARTVSELPEVKQHIVGPKENRALVNPIVERVR
IIHSADYIVVLDMNKIRLSHPLPSMIGTVSRGADEGPAFAEHTYTSKARGEIGTVVRAFVPIMNRHHEQIGVVIAAYRLP
TFLEAIDTLKEEIAMAVILSLLAGGSGAWLLASHIKRQMFELEPHEIAKLLVERTEAFNAMHEGVIAIDSNENITIFNDR
AKQMLGIEGDVIGQPIRSVIPDTYLPEILKVNKPIYNKELQLGNLTIWSNRIPIKVNGKTVGAIGIFQDRTEVKRLAEEL
TGVKAFVHALRVQNHEYMNKLHTIAGLIQLGHIEKALEYVFQVTEEQEELTQFLSRNIKDESISGLLLSKIRRGKELGIL
VTIDRHSHLYRFPPRLDHHDFVVLLGNLIENAFDAFQGVTGREKEIYVSIEQNEDICSLSIEDNGQGIAREHIDRIFDEG
FSTKGQNGRGIGLYLVKQIVEKGNGHIDVQSEEGKGTVFTITFDM

Specific function: Member of the two-component regulatory system dctS/dctR. Probably activates dctR by phosphorylation. Essential for expression of dctP [H]

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=529, Percent_Identity=33.0812854442344, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1786837, Length=531, Percent_Identity=29.5668549905838, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788549, Length=339, Percent_Identity=25.3687315634218, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790436, Length=105, Percent_Identity=38.0952380952381, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59089; Mature: 59089

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLPIRWKITILIFVIVSFSMLLSGVFIISDFFHTKEEELSQRALLTARTVSELPEVKQ
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HIVGPKENRALVNPIVERVRIIHSADYIVVLDMNKIRLSHPLPSMIGTVSRGADEGPAFA
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCHH
EHTYTSKARGEIGTVVRAFVPIMNRHHEQIGVVIAAYRLPTFLEAIDTLKEEIAMAVILS
HHCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAGGSGAWLLASHIKRQMFELEPHEIAKLLVERTEAFNAMHEGVIAIDSNENITIFNDR
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEHH
AKQMLGIEGDVIGQPIRSVIPDTYLPEILKVNKPIYNKELQLGNLTIWSNRIPIKVNGKT
HHHHHCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCCEEECCEEEECCCCEEEECCEE
VGAIGIFQDRTEVKRLAEELTGVKAFVHALRVQNHEYMNKLHTIAGLIQLGHIEKALEYV
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FQVTEEQEELTQFLSRNIKDESISGLLLSKIRRGKELGILVTIDRHSHLYRFPPRLDHHD
HHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCCCCCCCH
FVVLLGNLIENAFDAFQGVTGREKEIYVSIEQNEDICSLSIEDNGQGIAREHIDRIFDEG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCC
FSTKGQNGRGIGLYLVKQIVEKGNGHIDVQSEEGKGTVFTITFDM
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MNRLPIRWKITILIFVIVSFSMLLSGVFIISDFFHTKEEELSQRALLTARTVSELPEVKQ
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
HIVGPKENRALVNPIVERVRIIHSADYIVVLDMNKIRLSHPLPSMIGTVSRGADEGPAFA
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCCCCCHH
EHTYTSKARGEIGTVVRAFVPIMNRHHEQIGVVIAAYRLPTFLEAIDTLKEEIAMAVILS
HHCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAGGSGAWLLASHIKRQMFELEPHEIAKLLVERTEAFNAMHEGVIAIDSNENITIFNDR
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEHH
AKQMLGIEGDVIGQPIRSVIPDTYLPEILKVNKPIYNKELQLGNLTIWSNRIPIKVNGKT
HHHHHCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCCCCCEEECCEEEECCCCEEEECCEE
VGAIGIFQDRTEVKRLAEELTGVKAFVHALRVQNHEYMNKLHTIAGLIQLGHIEKALEYV
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FQVTEEQEELTQFLSRNIKDESISGLLLSKIRRGKELGILVTIDRHSHLYRFPPRLDHHD
HHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCCCCCCCH
FVVLLGNLIENAFDAFQGVTGREKEIYVSIEQNEDICSLSIEDNGQGIAREHIDRIFDEG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCC
FSTKGQNGRGIGLYLVKQIVEKGNGHIDVQSEEGKGTVFTITFDM
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10708364 [H]