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The map label for this gene is panF [H]

Identifier: 138893965

GI number: 138893965

Start: 326156

End: 327625

Strand: Direct

Name: panF [H]

Synonym: GTNG_0289

Alternate gene names: 138893965

Gene position: 326156-327625 (Clockwise)

Preceding gene: 138893964

Following gene: 138893966

Centisome position: 9.19

GC content: 38.16

Gene sequence:

>1470_bases
ATGAATTGGGAAGTAATTATACCATTAATCATATTCCTTTTGATCACTTTTAGCGTTGGGGTCTGGGCGAATAAATATGT
CAGTAAAACCAATTCCTTCCTTCAGGAATATTTTTTAGGGAGCAGGGAATTAGGTGGGTTTATTTTAGCCATGACTATGA
TGGCTACATATGGTAGTGCCAGTAGTTTTATTGGAGGACCGGGTGTTGCTTATACGACGGGATTAGGTTGGGTTTTGTTA
TCAATGGCACAACTACCAGCAGGATACTTTGTGTTAATGATTCTTGGGAAGAAGTTTGCTATTGCAGCAAGAAAGTATCA
AGCAATTACCTTAATCGATTTTTTGAAATCAAGATATGAAAGTAAATGGGTTGTGCTACTCTCCGCTTTAAGCATCATTA
TCTTCTTATTTTCAGCAATGGCTGCTCAATGGGTAGGGGGAGCTAGATTAATTGAATCGTTAACAGGTTTGTCCTATACA
ACAGCACTATTTATTTTTGCTGTTTCTGTGTTGGTCTATGTTATAATTGGTGGTTTTCGGGCTGTGGCTATGACGGATGC
TATTCAGGGAACCGTTATGTTTATTGGTACTTTCATTCTACTCATTGCCACCATCGTTGCCGGTGGAGGAGTATCAAACA
TTATCTCAGAGCTAGCGACAGAAAATCCAAATTTAATAACGCCATTTGGTGCGGAAGGAGAACTTACTCCATTATATGTA
TCTTCATTTTGGATTTTAGTAGGTGTTGGAGTTGTCGGATTGCCACAGATCACAGTTCGAGCCATGTCTTATAAAAACGC
TAAGGCGATGCATCGAGCAATTATTATTAGTACCGTATTTGTTGGTTTTATTATGCTCGCTATGCATCTAATTGGAGTTT
TTGCACGAGTAATTATACCAGGTGTAGAGATAGGCGATAAGGTAATGCCATTGCTTACCCTTCATGTTCTGCCTGCTTGG
TTAGCAGGGATTGTATTGACTGCTCCATTGGCTGCTATTATGTCTACAGTAGACTCTTTGTTAATATTGGTTAGTTCTTC
TATAGTAAAGGATGTTTATCTAAACTACATCAAACCGGAAGCAACGGAGAAACAAATTAAAACAGTAAGTTTTGGAGTAA
CAACGATTATTGGAATACTAGTTTTTCTGATGGCATTAAGTCCTCCAGATTTGTTGATTTGGCTAAATCTTTTCTCTTTT
GGCGGTTTAGAGGCTGCGTTTATTTGGCCAGTTATTCTAGGACTGTATTGGAAAAAGGGCAATAAATACGGAGCCATTGC
TTCCATGATTGTTGGTGTTGGCTCGTATATTGTCATTCACACATACTTTGGCAATTTATTCGGTTTACACACCGTGGTAG
TGCCTGTTCTTTTATCATGCATTGTTTATGTGCTTACTAGTCTAATTACAAATAAAACGATGGGAATGAAAGTAGACTAT
GGGTTAAGTCATCAAACAAAGGAGGTTTAA

Upstream 100 bases:

>100_bases
TAATTGTTATGTCCTTGCTTGTTTTCACTGTTGTTAAATTCTTTTTTAAAGAAGTTCCGTTTGACGAGGACGAAATCGAT
GGAGAAGGGAGGGGGGTAAA

Downstream 100 bases:

>100_bases
TTCATGAATAATTATGTTACGGATTCTACCCTTCGTCTTCTTCGAGATAGGGAGGAAGTGGTTAAGCTTACACAGGCACT
TGTGCGAATTCCAAGTGTGT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNWEVIIPLIIFLLITFSVGVWANKYVSKTNSFLQEYFLGSRELGGFILAMTMMATYGSASSFIGGPGVAYTTGLGWVLL
SMAQLPAGYFVLMILGKKFAIAARKYQAITLIDFLKSRYESKWVVLLSALSIIIFLFSAMAAQWVGGARLIESLTGLSYT
TALFIFAVSVLVYVIIGGFRAVAMTDAIQGTVMFIGTFILLIATIVAGGGVSNIISELATENPNLITPFGAEGELTPLYV
SSFWILVGVGVVGLPQITVRAMSYKNAKAMHRAIIISTVFVGFIMLAMHLIGVFARVIIPGVEIGDKVMPLLTLHVLPAW
LAGIVLTAPLAAIMSTVDSLLILVSSSIVKDVYLNYIKPEATEKQIKTVSFGVTTIIGILVFLMALSPPDLLIWLNLFSF
GGLEAAFIWPVILGLYWKKGNKYGAIASMIVGVGSYIVIHTYFGNLFGLHTVVVPVLLSCIVYVLTSLITNKTMGMKVDY
GLSHQTKEV

Sequences:

>Translated_489_residues
MNWEVIIPLIIFLLITFSVGVWANKYVSKTNSFLQEYFLGSRELGGFILAMTMMATYGSASSFIGGPGVAYTTGLGWVLL
SMAQLPAGYFVLMILGKKFAIAARKYQAITLIDFLKSRYESKWVVLLSALSIIIFLFSAMAAQWVGGARLIESLTGLSYT
TALFIFAVSVLVYVIIGGFRAVAMTDAIQGTVMFIGTFILLIATIVAGGGVSNIISELATENPNLITPFGAEGELTPLYV
SSFWILVGVGVVGLPQITVRAMSYKNAKAMHRAIIISTVFVGFIMLAMHLIGVFARVIIPGVEIGDKVMPLLTLHVLPAW
LAGIVLTAPLAAIMSTVDSLLILVSSSIVKDVYLNYIKPEATEKQIKTVSFGVTTIIGILVFLMALSPPDLLIWLNLFSF
GGLEAAFIWPVILGLYWKKGNKYGAIASMIVGVGSYIVIHTYFGNLFGLHTVVVPVLLSCIVYVLTSLITNKTMGMKVDY
GLSHQTKEV
>Mature_489_residues
MNWEVIIPLIIFLLITFSVGVWANKYVSKTNSFLQEYFLGSRELGGFILAMTMMATYGSASSFIGGPGVAYTTGLGWVLL
SMAQLPAGYFVLMILGKKFAIAARKYQAITLIDFLKSRYESKWVVLLSALSIIIFLFSAMAAQWVGGARLIESLTGLSYT
TALFIFAVSVLVYVIIGGFRAVAMTDAIQGTVMFIGTFILLIATIVAGGGVSNIISELATENPNLITPFGAEGELTPLYV
SSFWILVGVGVVGLPQITVRAMSYKNAKAMHRAIIISTVFVGFIMLAMHLIGVFARVIIPGVEIGDKVMPLLTLHVLPAW
LAGIVLTAPLAAIMSTVDSLLILVSSSIVKDVYLNYIKPEATEKQIKTVSFGVTTIIGILVFLMALSPPDLLIWLNLFSF
GGLEAAFIWPVILGLYWKKGNKYGAIASMIVGVGSYIVIHTYFGNLFGLHTVVVPVLLSCIVYVLTSLITNKTMGMKVDY
GLSHQTKEV

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=492, Percent_Identity=30.0813008130081, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI14140236, Length=479, Percent_Identity=24.2171189979123, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17941285, Length=458, Percent_Identity=23.5807860262009, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI157671931, Length=414, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI11141885, Length=454, Percent_Identity=25.1101321585903, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4507033, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI87082237, Length=455, Percent_Identity=50.3296703296703, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1787251, Length=456, Percent_Identity=27.1929824561404, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1790503, Length=442, Percent_Identity=24.4343891402715, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790113, Length=489, Percent_Identity=23.5173824130879, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539284, Length=461, Percent_Identity=26.0303687635575, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648033, Length=454, Percent_Identity=25.3303964757709, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21356865, Length=454, Percent_Identity=25.3303964757709, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573698, Length=380, Percent_Identity=22.8947368421053, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52913; Mature: 52913

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCC
>Mature Secondary Structure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CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]