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The map label for this gene is purM [H]

Identifier: 138893921

GI number: 138893921

Start: 273482

End: 274522

Strand: Direct

Name: purM [H]

Synonym: GTNG_0245

Alternate gene names: 138893921

Gene position: 273482-274522 (Clockwise)

Preceding gene: 138893920

Following gene: 138893922

Centisome position: 7.7

GC content: 53.7

Gene sequence:

>1041_bases
GTGGTAAAAGCATACAAACAAGCAGGGGTTGACATTGAGGCCGGCTATCAGGCGGTCGCCCTGATGAAACAGCATGTGCA
GAAGACGATGCGTCCGGAAGTGTTAGGCGGGATCGGTGGGTTTGGCGGCTTGTTTGATTTATCGTCGCTTGACTACCGCC
AGCCGGTGCTTGTTTCCGGTACGGATGGCGTCGGGACGAAGCTGAAATTGGCATTTTTGCTTGACCGACACAATACGATC
GGCATTGACTGTGTGGCGATGTGCGTGAATGACATCGTTGTACAAGGGGCGGAACCGCTCTTTTTCCTTGATTATATCGC
TTGCGGCAAGGCGGTGCCGGAAAAAATCGCTGCTATCGTCAAAGGGGTGGCTGACGGCTGCGTCGAAGCTGGCTGTGCCT
TGATTGGCGGAGAAACGGCGGAAATGCCGGGAATGTATGCGGAAGACGAGTACGATTTAGCCGGGTTTGTTGTCGGCATT
GCTGAAAAAGAACGGTTGGTGACGGGACAAACGATCCAAGCGGGGGATGTGTTGATTGGACTTCCGTCAAGCGGTCTGCA
TAGCAACGGCTACTCGCTGGTACGCCGTATCATTTTCGAACAAGCAAAGCTGTCGCTTGATGAGATTTATGAGCCGCTTG
ATGTTCCGCTTGGCGAGGAGCTACTAAAGCCGACACGCATTTATGCGAAACTGTTGCGTTCGGTGCTTGGACGATTTACG
ATCAAAGGGATGGCGCATATTACCGGTGGCGGGTTTATCGAAAACATTCCACGCATGTTGCCACAAGGGCTTGGCGTCCG
CATTCAGCGCGGTTCGTGGCCGGTGCTGCCGATTTTTGACTTCCTGCGCGCCAAAGGCAACCTTGAGGAAGAAGAGATGT
TTTCGGTATTTAATATGGGCATTGGCCTCGTGCTCGCTGTCAGCCCAGAAACAGCGGCGCCGCTTGTGCAATGGTTGGAC
GAACAAAACGAGCCGGCCTACATCATTGGAGAAGTGGTGGAAGGAGCAGGCGTGTCGTTTACCGGAGGGAACGAAGCATG
A

Upstream 100 bases:

>100_bases
TGATCAATGATCAGCGTGCTTCAAGTTGGAAGGGGACAACGGACAGCAAGGTGCTTGTCGCATGCTTGGGTGCAGCGGGC
GAAGAAAAGGGGGATTTAGC

Downstream 100 bases:

>100_bases
AGCGGTTGGCCGTGTTTGCTTCTGGAAGCGGAACGAATTTTCAGGCGATCGTCGATGCGGTGAAGCGCGGTGAGTTGCCG
GCCGATCTTGCCCTTCTTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSGTDGVGTKLKLAFLLDRHNTI
GIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIVKGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGI
AEKERLVTGQTIQAGDVLIGLPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFT
IKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMGIGLVLAVSPETAAPLVQWLD
EQNEPAYIIGEVVEGAGVSFTGGNEA

Sequences:

>Translated_346_residues
MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSGTDGVGTKLKLAFLLDRHNTI
GIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIVKGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGI
AEKERLVTGQTIQAGDVLIGLPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFT
IKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMGIGLVLAVSPETAAPLVQWLD
EQNEPAYIIGEVVEGAGVSFTGGNEA
>Mature_346_residues
MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSGTDGVGTKLKLAFLLDRHNTI
GIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIVKGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGI
AEKERLVTGQTIQAGDVLIGLPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFT
IKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMGIGLVLAVSPETAAPLVQWLD
EQNEPAYIIGEVVEGAGVSFTGGNEA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=338, Percent_Identity=50.5917159763314, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI209869995, Length=338, Percent_Identity=50.5917159763314, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI209869993, Length=338, Percent_Identity=50.5917159763314, Blast_Score=319, Evalue=3e-87,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=51.8292682926829, Blast_Score=334, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17567511, Length=334, Percent_Identity=40.7185628742515, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=44.8979591836735, Blast_Score=280, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24582400, Length=285, Percent_Identity=44.9122807017544, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37048; Mature: 37048

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCCCCCCCCCEEEEC
TDGVGTKLKLAFLLDRHNTIGIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIV
CCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGIAEKERLVTGQTIQAGDVLIG
HHHHHHHHHHCHHEECCCCCCCCCCCCCCCCCHHHEEEEECCCCCEECCCEEECCCEEEE
LPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFT
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMG
HCCHHEECCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
IGLVLAVSPETAAPLVQWLDEQNEPAYIIGEVVEGAGVSFTGGNEA
CEEEEEECCCHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVKAYKQAGVDIEAGYQAVALMKQHVQKTMRPEVLGGIGGFGGLFDLSSLDYRQPVLVSG
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHHCCCCCCCCCCEEEEC
TDGVGTKLKLAFLLDRHNTIGIDCVAMCVNDIVVQGAEPLFFLDYIACGKAVPEKIAAIV
CCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KGVADGCVEAGCALIGGETAEMPGMYAEDEYDLAGFVVGIAEKERLVTGQTIQAGDVLIG
HHHHHHHHHHCHHEECCCCCCCCCCCCCCCCCHHHEEEEECCCCCEECCCEEECCCEEEE
LPSSGLHSNGYSLVRRIIFEQAKLSLDEIYEPLDVPLGEELLKPTRIYAKLLRSVLGRFT
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IKGMAHITGGGFIENIPRMLPQGLGVRIQRGSWPVLPIFDFLRAKGNLEEEEMFSVFNMG
HCCHHEECCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
IGLVLAVSPETAAPLVQWLDEQNEPAYIIGEVVEGAGVSFTGGNEA
CEEEEEECCCHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA