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The map label for this gene is guaA [H]

Identifier: 138893907

GI number: 138893907

Start: 252356

End: 253897

Strand: Direct

Name: guaA [H]

Synonym: GTNG_0231

Alternate gene names: 138893907

Gene position: 252356-253897 (Clockwise)

Preceding gene: 138893906

Following gene: 138893908

Centisome position: 7.11

GC content: 49.94

Gene sequence:

>1542_bases
GTGGATAAGATGAACCAAGAAATGATCGTCGTATTGGACTTCGGAAGCCAATATAACCAACTGATTACTCGCCGCATCCG
TGAATTTGGCGTCTACAGCGAACTGCATCCGCACACGATCAGTGCGGAAGAAATTCGCGCGTTAAATGCTAAAGGAATCA
TTTTTTCCGGTGGTCCGAACAGCGTATATGATGAACAAGCGTTTACGTGCGATCCAGCGATTTTTGAACTCGGGCTGCCA
ATCTTGGGGATTTGTTACGGGATGCAGCTTATGGCGCACCACTTGGGCGGCAAAGTGGAAAAAGCCACACACCGTGAATA
CGGCAAAGCGCTTATCCAAGTGAAAAATGATTCTTTGCTATTCCGCGGGTTGCCGGATGAACAAGTCGTCTGGATGAGCC
ACGGCGATTTAGTGACTGCCCCGCCGTCCGGTTTTATCGTCGATGCGACAAGTTCTTCCTGCCCGATCGCCGCGATGAGC
GATGAACGTCGGAAATGGTACGGGGTGCAATTCCATCCGGAAGTGCGTCATTCCATTTATGGAAATGATGTACTGAAGCG
GTTTGTTTTCGACGTATGCGGCTGTCACGGCGACTGGACGATGGAAAACTTCATCGATGAGCAAGTGCGTCGCATTCGTG
AACAAGTTGGCGGGAAAAAAGTGCTTTGTGCATTAAGCGGTGGAGTTGATTCATCGGTTGCCGCTGTATTGGTGCATCGT
GCCATCGGTGATCAGCTCACATGCATTTTTGTTGATCACGGCCTTCTTCGCAAAGGCGAAGCGGAAAGCGTCATGAAAAC
GTTCCGCGAACAGTTCCAGATGAACGTCATTAAAGTGGATGCGAAAGAACGCTTTTTGGCGAAATTAAAAGGGGTCTCCG
ACCCGGAACAAAAGCGGAAAATCATCGGCAACGAATTTATTTATGTGTTTGACGATGAGGCGGCCAAGCTCGAAGGCATT
GAATTTTTAGTGCAAGGCACGCTTTATACTGACATTATTGAAAGTGGCACAGCAACGGCACAAACGATTAAATCGCATCA
TAACGTCGGCGGCTTGCCGGAAGATATGAAATTTGAATTGATCGAGCCACTCAATACGCTGTTTAAAGATGAGGTACGCG
CACTTGGCACACAATTGGGCATTCCGGACGAAATCGTCTGGCGTCAGCCGTTCCCGGGACCTGGTCTTGGGATTCGCGTT
CTTGGTGAAGTGACGGAAGAAAAGTTGGAAATCGTCCGTGAATCGGATGCGATTTTGCGGGAAGAAGTGAAAAAAGCTGG
ACTCGACCGTGAAATTTGGCAATATTTCACCGTTCTCCCTGATATCCGCAGCGTCGGAGTGATGGGGGATGCCCGCACGT
ACGATTATACGGTCGCCATTCGCGCGGTGACATCGATCGATGGGATGACCGCCGACTGGGCTCGCATTCCTTGGGATGTG
CTCGAACGCATTTCAACACGTATCGTGAACGAAGTGCCGCACGTCAATCGCGTCGTCTACGATATTACAAGTAAACCGCC
CGCGACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
CCGGGCCGCCGTAAACGGCCTGACTATGAAGGCAGAAGACGCTGCTATTCTGCCTTCATCATGTTATTTGGGCGATGGCA
GCGCTTATTTTTTCGACGGG

Downstream 100 bases:

>100_bases
TATAAAATTGATGGTTAAGTCGTCTGTTCCATAAATGGAGTAGGCGACTTTTTTGTGTCCAGAAAAATAGTATATGGTAA
AGAAACAATAAAATATTTTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MDKMNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTISAEEIRALNAKGIIFSGGPNSVYDEQAFTCDPAIFELGLP
ILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLLFRGLPDEQVVWMSHGDLVTAPPSGFIVDATSSSCPIAAMS
DERRKWYGVQFHPEVRHSIYGNDVLKRFVFDVCGCHGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHR
AIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKERFLAKLKGVSDPEQKRKIIGNEFIYVFDDEAAKLEGI
EFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFELIEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRV
LGEVTEEKLEIVRESDAILREEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDV
LERISTRIVNEVPHVNRVVYDITSKPPATIEWE

Sequences:

>Translated_513_residues
MDKMNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTISAEEIRALNAKGIIFSGGPNSVYDEQAFTCDPAIFELGLP
ILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLLFRGLPDEQVVWMSHGDLVTAPPSGFIVDATSSSCPIAAMS
DERRKWYGVQFHPEVRHSIYGNDVLKRFVFDVCGCHGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHR
AIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKERFLAKLKGVSDPEQKRKIIGNEFIYVFDDEAAKLEGI
EFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFELIEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRV
LGEVTEEKLEIVRESDAILREEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDV
LERISTRIVNEVPHVNRVVYDITSKPPATIEWE
>Mature_513_residues
MDKMNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTISAEEIRALNAKGIIFSGGPNSVYDEQAFTCDPAIFELGLP
ILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLLFRGLPDEQVVWMSHGDLVTAPPSGFIVDATSSSCPIAAMS
DERRKWYGVQFHPEVRHSIYGNDVLKRFVFDVCGCHGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHR
AIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKERFLAKLKGVSDPEQKRKIIGNEFIYVFDDEAAKLEGI
EFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFELIEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRV
LGEVTEEKLEIVRESDAILREEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDV
LERISTRIVNEVPHVNRVVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=39.4881170018282, Blast_Score=328, Evalue=1e-89,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=54.6845124282983, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1789760, Length=155, Percent_Identity=35.4838709677419, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=37.9613356766257, Blast_Score=321, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=37.9613356766257, Blast_Score=321, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=37.9613356766257, Blast_Score=320, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=55.0387596899225, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=36.8613138686131, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57655; Mature: 57655

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKMNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTISAEEIRALNAKGIIFSGGPN
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHCCCCEEEEECCCC
SVYDEQAFTCDPAIFELGLPILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCEE
FRGLPDEQVVWMSHGDLVTAPPSGFIVDATSSSCPIAAMSDERRKWYGVQFHPEVRHSIY
EECCCCCEEEEEECCCEEECCCCCEEEECCCCCCCEEECCCCCHHEECEEECHHHHHHHH
GNDVLKRFVFDVCGCHGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKERFLAKLKGVSDPEQKRK
HHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDDEAAKLEGIEFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFEL
HCCCCEEEEECCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHH
IEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDV
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHCCCCCCCHHCCCHHH
LERISTRIVNEVPHVNRVVYDITSKPPATIEWE
HHHHHHHHHHHCCCCCEEEEEECCCCCCCEECC
>Mature Secondary Structure
MDKMNQEMIVVLDFGSQYNQLITRRIREFGVYSELHPHTISAEEIRALNAKGIIFSGGPN
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHCCCCEEEEECCCC
SVYDEQAFTCDPAIFELGLPILGICYGMQLMAHHLGGKVEKATHREYGKALIQVKNDSLL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCEE
FRGLPDEQVVWMSHGDLVTAPPSGFIVDATSSSCPIAAMSDERRKWYGVQFHPEVRHSIY
EECCCCCEEEEEECCCEEECCCCCEEEECCCCCCCEEECCCCCHHEECEEECHHHHHHHH
GNDVLKRFVFDVCGCHGDWTMENFIDEQVRRIREQVGGKKVLCALSGGVDSSVAAVLVHR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEAESVMKTFREQFQMNVIKVDAKERFLAKLKGVSDPEQKRK
HHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDDEAAKLEGIEFLVQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMKFEL
HCCCCEEEEECCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHH
IEPLNTLFKDEVRALGTQLGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEVKKAGLDREIWQYFTVLPDIRSVGVMGDARTYDYTVAIRAVTSIDGMTADWARIPWDV
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHCCCCCCCHHCCCHHH
LERISTRIVNEVPHVNRVVYDITSKPPATIEWE
HHHHHHHHHHHCCCCCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA