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The map label for this gene is yhaU [H]

Identifier: 138893900

GI number: 138893900

Start: 242530

End: 243774

Strand: Reverse

Name: yhaU [H]

Synonym: GTNG_0224

Alternate gene names: 138893900

Gene position: 243774-242530 (Counterclockwise)

Preceding gene: 138893901

Following gene: 138893897

Centisome position: 6.87

GC content: 42.81

Gene sequence:

>1245_bases
ATGAACCACTTAGTACTGGAAGTGGGAACGGCACTCGTTTTAGTCGCTATTGGATCCATCATTGCCAATAGATTAAACTT
CTCCATTATCCCGTTTTTGATCATCATCGGCATGCTGGTTGGGCCCCATGCCCCTACAATTGGGATTATTGACCTCACTT
TTATTGAAAGTAATGAAATTATCCAGTTTCTAGGGAGGATCGGGGTACTTTTTTTGCTGTTTTATTTAGGTCTTGAATTT
TCTGTCGGCAAGCTGATTAAGTCCGGAAAAAACATTGTGGTTGGTGGCAGCATCTATGTCATAATGAACTTTGTTTTAGG
ATTGGTTTATGGCAAAACCGTAGGAATGCCATGGATGGAAACCCTTCTGATTGCCGGGCTCCTCAGTGTATCATCAAGTG
CCATCGTGGCCAAAGTTCTCGTCGATTTAAGGAGAACGGCCAATCCTGAAACAGAGCTCATTTTAGGGATGATCCTTTTT
GATGACATCTTCCTTGCCCTATTTTTGACGACGATGTCAGGGGTTTTGCTAGCTGGATCCACCTCCTTTTTCGGAATCAG
CCTATCGGTTTTAACATCTGTTGCTTATATGCTGCTATTTTTTGTCATCGCTCGTAAAGGTGCCCCTCTACTGAACAAAT
GGTTAAATATCAAATCCGATGAAATATTCATCATCGTTATCTTTGCTATTCTCTTTTTCGTTGCCGGCTTTTCCGAAACG
CTTCATGTCGCTGAAGCTATCGGGGCCTTACTACTGGGGCTTGTCTTTTCGGAAACCGAACACCGCGATCGAATCGAACA
TTTAGTTGTTCCATTCCGCGACTTCTTTGGAGCTATCTTTTTCTTTAGTTTCGGTTTGACTATTGAACCATCCACCTTAA
TTCATGCGTTTTGGTTATCATTAGGAGCCGTTATCGTCACTCTACTAGCCAATATGGTGGCGGGAATGATCGCCGGAAGA
AAGGCTGGATTGTCCTACAAAGCCTCTACAAACATTGGTTTAACGATCACGGCGCGTGGGGAATTTTCTATTGTCGTTGC
GAATCTAGGGATTACAGCGGGGTTAAACCCTATCTTAACTCCTTTTACCGCTCTTTACGTTCTCATGCTCGCGATATTGG
GACCGCTCTTTGCCAAAGAAAGCAAAACGATCTATAAACTACTCAACAAAGTATTTAAATGGGATAAGAAGCTAGCTAAG
GAGAAGGAGAAGCAAAAGGAAAGAGTCGAAGTTGCGGAAAAATAA

Upstream 100 bases:

>100_bases
GTTGATTGAAGCTGGGGATACATTAATCATGTCTGGAGAAAGACAACAAATAAAGGAGATCATGAATCATCTACTATCAA
ATAAGGAGTGATGGGAATAA

Downstream 100 bases:

>100_bases
GTAACGGCTGCAACATCCTTCTTTATCGCTCGTTTACTCCAATCCATCTCTTATCTCCTTCTTCCGAGTGGACGCTCAGT
CACCGGATCAAAGGCCATTC

Product: Na+/H+ antiporter NapA-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNHLVLEVGTALVLVAIGSIIANRLNFSIIPFLIIIGMLVGPHAPTIGIIDLTFIESNEIIQFLGRIGVLFLLFYLGLEF
SVGKLIKSGKNIVVGGSIYVIMNFVLGLVYGKTVGMPWMETLLIAGLLSVSSSAIVAKVLVDLRRTANPETELILGMILF
DDIFLALFLTTMSGVLLAGSTSFFGISLSVLTSVAYMLLFFVIARKGAPLLNKWLNIKSDEIFIIVIFAILFFVAGFSET
LHVAEAIGALLLGLVFSETEHRDRIEHLVVPFRDFFGAIFFFSFGLTIEPSTLIHAFWLSLGAVIVTLLANMVAGMIAGR
KAGLSYKASTNIGLTITARGEFSIVVANLGITAGLNPILTPFTALYVLMLAILGPLFAKESKTIYKLLNKVFKWDKKLAK
EKEKQKERVEVAEK

Sequences:

>Translated_414_residues
MNHLVLEVGTALVLVAIGSIIANRLNFSIIPFLIIIGMLVGPHAPTIGIIDLTFIESNEIIQFLGRIGVLFLLFYLGLEF
SVGKLIKSGKNIVVGGSIYVIMNFVLGLVYGKTVGMPWMETLLIAGLLSVSSSAIVAKVLVDLRRTANPETELILGMILF
DDIFLALFLTTMSGVLLAGSTSFFGISLSVLTSVAYMLLFFVIARKGAPLLNKWLNIKSDEIFIIVIFAILFFVAGFSET
LHVAEAIGALLLGLVFSETEHRDRIEHLVVPFRDFFGAIFFFSFGLTIEPSTLIHAFWLSLGAVIVTLLANMVAGMIAGR
KAGLSYKASTNIGLTITARGEFSIVVANLGITAGLNPILTPFTALYVLMLAILGPLFAKESKTIYKLLNKVFKWDKKLAK
EKEKQKERVEVAEK
>Mature_414_residues
MNHLVLEVGTALVLVAIGSIIANRLNFSIIPFLIIIGMLVGPHAPTIGIIDLTFIESNEIIQFLGRIGVLFLLFYLGLEF
SVGKLIKSGKNIVVGGSIYVIMNFVLGLVYGKTVGMPWMETLLIAGLLSVSSSAIVAKVLVDLRRTANPETELILGMILF
DDIFLALFLTTMSGVLLAGSTSFFGISLSVLTSVAYMLLFFVIARKGAPLLNKWLNIKSDEIFIIVIFAILFFVAGFSET
LHVAEAIGALLLGLVFSETEHRDRIEHLVVPFRDFFGAIFFFSFGLTIEPSTLIHAFWLSLGAVIVTLLANMVAGMIAGR
KAGLSYKASTNIGLTITARGEFSIVVANLGITAGLNPILTPFTALYVLMLAILGPLFAKESKTIYKLLNKVFKWDKKLAK
EKEKQKERVEVAEK

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=349, Percent_Identity=28.9398280802292, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786685, Length=370, Percent_Identity=25.4054054054054, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786232, Length=282, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45140; Mature: 45140

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLVLEVGTALVLVAIGSIIANRLNFSIIPFLIIIGMLVGPHAPTIGIIDLTFIESNEI
CCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHH
IQFLGRIGVLFLLFYLGLEFSVGKLIKSGKNIVVGGSIYVIMNFVLGLVYGKTVGMPWME
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHH
TLLIAGLLSVSSSAIVAKVLVDLRRTANPETELILGMILFDDIFLALFLTTMSGVLLAGS
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
TSFFGISLSVLTSVAYMLLFFVIARKGAPLLNKWLNIKSDEIFIIVIFAILFFVAGFSET
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHH
LHVAEAIGALLLGLVFSETEHRDRIEHLVVPFRDFFGAIFFFSFGLTIEPSTLIHAFWLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHH
LGAVIVTLLANMVAGMIAGRKAGLSYKASTNIGLTITARGEFSIVVANLGITAGLNPILT
HHHHHHHHHHHHHHHHHHCHHCCCCEEECCCCEEEEEECCCEEEEEEECCCCCCCCHHHH
PFTALYVLMLAILGPLFAKESKTIYKLLNKVFKWDKKLAKEKEKQKERVEVAEK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHLVLEVGTALVLVAIGSIIANRLNFSIIPFLIIIGMLVGPHAPTIGIIDLTFIESNEI
CCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHH
IQFLGRIGVLFLLFYLGLEFSVGKLIKSGKNIVVGGSIYVIMNFVLGLVYGKTVGMPWME
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHH
TLLIAGLLSVSSSAIVAKVLVDLRRTANPETELILGMILFDDIFLALFLTTMSGVLLAGS
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
TSFFGISLSVLTSVAYMLLFFVIARKGAPLLNKWLNIKSDEIFIIVIFAILFFVAGFSET
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHH
LHVAEAIGALLLGLVFSETEHRDRIEHLVVPFRDFFGAIFFFSFGLTIEPSTLIHAFWLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHH
LGAVIVTLLANMVAGMIAGRKAGLSYKASTNIGLTITARGEFSIVVANLGITAGLNPILT
HHHHHHHHHHHHHHHHHHCHHCCCCEEECCCCEEEEEECCCEEEEEEECCCCCCCCHHHH
PFTALYVLMLAILGPLFAKESKTIYKLLNKVFKWDKKLAKEKEKQKERVEVAEK
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]