Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 138893899

GI number: 138893899

Start: 240255

End: 241877

Strand: Direct

Name: groEL

Synonym: GTNG_0223

Alternate gene names: 138893899

Gene position: 240255-241877 (Clockwise)

Preceding gene: 138893898

Following gene: 138893902

Centisome position: 6.77

GC content: 50.83

Gene sequence:

>1623_bases
ATGGCAAAAGAAATTAAGTTCAGCGAAGAAGCGCGCCGTGCGATGTTGCGCGGGGTGGACAAACTCGCAGACGCAGTAAA
AGTCACATTAGGTCCGAAAGGCCGCAACGTCGTATTGGAGAAAAAATTCGGTTCTCCGCTCATCACGAACGACGGGGTAA
CGATTGCGAAAGAAATCGAGCTTGAAGACCCGTTTGAAAACATGGGTGCGAAATTGGTCGCTGAAGTCGCTAGCAAAACA
AACGACATCGCTGGGGACGGAACGACAACGGCTACTGTATTAGCGCAAGCAATGATCCGTGAAGGGTTGAAAAACGTTGC
TGCTGGCGCCAATCCGATGGGCATCCGTCGCGGGATTGAAAAAGCAGTGGCTGTTGCTGTAGAAGAATTAAAAGCTATCT
CGAAACCGATCAAAGGAAAAGAGTCGATCGCCCAAGTTGCTGCGATCTCGGCTGCTGACGAAGAAGTCGGTCAATTGATC
GCTGAAGCGATGGAGCGCGTCGGCAACGACGGCGTCATCACCCTCGAAGAGTCGAAAGGTTTCACGACAGAACTCGACGT
TGTCGAAGGAATGCAATTCGACCGCGGTTACGTTTCGCCGTACATGATTACGGATACGGAAAAAATGGAAGCTGTTCTTG
AAAATCCGTACATCTTAATTACGGATAAAAAAGTATCGAACATTCAAGAGCTGTTGCCGGTTCTTGAACAAGTCGTTCAA
CAAGGCCGTCCGCTCTTGATCATTGCTGAGGACGTCGAAGGTGAAGCGCTCGCGACCCTCGTTGTTAACAAACTGCGCGG
TACGTTCAACGCTGTTGCTGTAAAAGCACCTGGCTTCGGTGACCGTCGCAAAGCGATGCTCGAAGATATCGCGATTTTAA
CTGGCGGCGAAGTCATCTCTGAAGAGCTTGGTCGTGAACTGAAATCGACAACGGTTGCATCGCTTGGCCGTGCGTCGAAA
GTTGTTGTCACGAAAGAAACGACGACAATCGTCGAAGGTGCTGGCGATTCTGAGCGCATTAAAGCACGCATTAACCAAAT
TCGTGCGCAACTTGAAGAAACTACTTCGGAATTCGACCGCGAAAAACTGCAAGAACGCTTGGCAAAATTGGCTGGCGGCG
TAGCAGTGATCAAAGTTGGTGCGGCGACAGAAACTGAGTTGAAAGAACGCAAACTGCGCATCGAAGACGCGCTTAACTCG
ACTCGTGCTGCTGTAGAAGAAGGTATCGTTGCTGGTGGCGGTACGGCATTGATGAACGTCTACAGCAAAGTGGCTGCGAT
TGAAGCTGAAGGCGATGAAGCAACGGGTGTGAAAATCGTTCTGCGCGCCATCGAAGAGCCGGTTCGTCAAATCGCGCAAA
ATGCTGGTTTGGAAGGCTCGATCATCGTTGAGCGCCTGAAAAACGAAAAAGCAGGCATCGGCTTCAATGCTGCAACAGGT
GAATGGGTAGACATGATCGAAGAGGGTATCGTTGACCCAACGAAAGTAACTCGTTCGGCATTGCAAAACGCTGCGTCTGT
CGCTGCTATGGTCTTGACGACAGAAGCGGTCGTTGCCGACAAGCCAGAAGAAAACAAAGGTGGCGCCAACCCGGGTATGC
CGGACATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
TATGCGTTTATGACATAGATATTCCAAAAACATACTTACTATTTCATACTTAATCTTTCTAGTATGCGGTTTCACTAATT
TATAAGGAGGTAACGGGGTA

Downstream 100 bases:

>100_bases
TCCACCTAGTCAAAAAAGGAACACTGGGAATATTCCCAGTGTTCCTTTTCTTTTTGGAGAGGGGAAAAGTTATTCTCTCT
TTCTATTGAATGGTGATAGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVAEVASKT
NDIAGDGTTTATVLAQAMIREGLKNVAAGANPMGIRRGIEKAVAVAVEELKAISKPIKGKESIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSNIQELLPVLEQVVQ
QGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRELKSTTVASLGRASK
VVVTKETTTIVEGAGDSERIKARINQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTALMNVYSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSIIVERLKNEKAGIGFNAATG
EWVDMIEEGIVDPTKVTRSALQNAASVAAMVLTTEAVVADKPEENKGGANPGMPDMGGMM

Sequences:

>Translated_540_residues
MAKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVAEVASKT
NDIAGDGTTTATVLAQAMIREGLKNVAAGANPMGIRRGIEKAVAVAVEELKAISKPIKGKESIAQVAAISAADEEVGQLI
AEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSNIQELLPVLEQVVQ
QGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRELKSTTVASLGRASK
VVVTKETTTIVEGAGDSERIKARINQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVAGGGTALMNVYSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSIIVERLKNEKAGIGFNAATG
EWVDMIEEGIVDPTKVTRSALQNAASVAAMVLTTEAVVADKPEENKGGANPGMPDMGGMM
>Mature_539_residues
AKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDPFENMGAKLVAEVASKTN
DIAGDGTTTATVLAQAMIREGLKNVAAGANPMGIRRGIEKAVAVAVEELKAISKPIKGKESIAQVAAISAADEEVGQLIA
EAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSNIQELLPVLEQVVQQ
GRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRELKSTTVASLGRASKV
VVTKETTTIVEGAGDSERIKARINQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNST
RAAVEEGIVAGGGTALMNVYSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSIIVERLKNEKAGIGFNAATGE
WVDMIEEGIVDPTKVTRSALQNAASVAAMVLTTEAVVADKPEENKGGANPGMPDMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=50.4725897920605, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=50.4725897920605, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI38455427, Length=571, Percent_Identity=24.6935201401051, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI24307939, Length=228, Percent_Identity=27.6315789473684, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI5453603, Length=566, Percent_Identity=23.6749116607774, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=64.4486692015209, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=49.6212121212121, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI193210679, Length=216, Percent_Identity=48.1481481481481, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI25147750, Length=550, Percent_Identity=25.6363636363636, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17564182, Length=541, Percent_Identity=22.735674676525, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25144674, Length=185, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71998178, Length=599, Percent_Identity=21.3689482470785, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532601, Length=166, Percent_Identity=30.1204819277108, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.2442748091603, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322524, Length=570, Percent_Identity=22.1052631578947, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322446, Length=555, Percent_Identity=23.0630630630631, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322350, Length=563, Percent_Identity=22.5577264653641, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322049, Length=98, Percent_Identity=38.7755102040816, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320058, Length=152, Percent_Identity=27.6315789473684, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=50.7575757575758, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=50.7575757575758, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=47.7186311787072, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=47.7186311787072, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=47.7186311787072, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=42.1052631578947, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=35.2720450281426, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=35.2720450281426, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24645179, Length=517, Percent_Identity=23.5976789168279, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583944, Length=548, Percent_Identity=24.4525547445255, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571140, Length=575, Percent_Identity=23.8260869565217, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18858175, Length=575, Percent_Identity=23.8260869565217, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647245, Length=575, Percent_Identity=23.8260869565217, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652903, Length=564, Percent_Identity=24.113475177305, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_GEOTN (A4IJV3)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124352.1
- ProteinModelPortal:   A4IJV3
- SMR:   A4IJV3
- STRING:   A4IJV3
- GeneID:   4965076
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0223
- NMPDR:   fig|420246.5.peg.221
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- PhylomeDB:   A4IJV3
- ProtClustDB:   PRK00013
- BioCyc:   GTHE420246:GTNG_0223-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57386; Mature: 57254

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEECCCCEEEEECC
LEDPFENMGAKLVAEVASKTNDIAGDGTTTATVLAQAMIREGLKNVAAGANPMGIRRGIE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVAVAVEELKAISKPIKGKESIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSNIQELLPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVIS
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRELKSTTVASLGRASKVVVTKETTTIVEGAGDSERIKARINQIRAQLEETTSEFDR
HHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTALMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSIIVERLKNEKAGIGFNAATG
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
EWVDMIEEGIVDPTKVTRSALQNAASVAAMVLTTEAVVADKPEENKGGANPGMPDMGGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKEIKFSEEARRAMLRGVDKLADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEECCCCEEEEECC
LEDPFENMGAKLVAEVASKTNDIAGDGTTTATVLAQAMIREGLKNVAAGANPMGIRRGIE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVAVAVEELKAISKPIKGKESIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELDVVEGMQFDRGYVSPYMITDTEKMEAVLENPYILITDKKVSNIQELLPVLEQVVQ
CEEEHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGEVIS
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGRELKSTTVASLGRASKVVVTKETTTIVEGAGDSERIKARINQIRAQLEETTSEFDR
HHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTALMNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YSKVAAIEAEGDEATGVKIVLRAIEEPVRQIAQNAGLEGSIIVERLKNEKAGIGFNAATG
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
EWVDMIEEGIVDPTKVTRSALQNAASVAAMVLTTEAVVADKPEENKGGANPGMPDMGGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA