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The map label for this gene is fumC [H]

Identifier: 138893902

GI number: 138893902

Start: 245024

End: 246394

Strand: Direct

Name: fumC [H]

Synonym: GTNG_0226

Alternate gene names: 138893902

Gene position: 245024-246394 (Clockwise)

Preceding gene: 138893899

Following gene: 138893904

Centisome position: 6.9

GC content: 52.15

Gene sequence:

>1371_bases
ATGAACGAACGAATAGAGCGCGACTCGCTTGGGGAGGTGCGGGTGCCGGCCGATAAATACTGGGGAGCGCAAACGGAGCG
AAGCCGGCAAAACTTCCGCATCGGCAAAGAAACGATGCCGCTTGAACTCATTTATGCTTATGCCGAGCTGAAAAAAGCGG
CGGCCATCGTCAACGAGCAAGCTGGAAAGTTGAGTGAAGCAAAGAGGCAGGCGATTGTGACGGCTTGCGACGAGATTTTG
GCTGGCCAATGGGATGCACATTTCCCTCTTGTTGTTTGGCAGACGGGAAGCGGGACGCAGACGAATATGAACGTCAATGA
AGTGGTGGCTAGACGGGCGAACGAGCTACTCCCTGACGGGGAGGAACGCATTCATCCGAACGACGATGTCAATATGTCGC
AAAGCTCAAATGACACGTTCCCAACGGTGATGCATATCGCTATTTATACGAAAATTCAAACGCATCTTCTGCCGGCAATT
GATCGTTTGATTGGCACGTTTGCGGCCAAAGAACGTCGCTATGAGAAGACGATCAAAGTTGGGCGCACTCACTTGCAAGA
TGCGACACCGCTCACATTTGGACAAGAGATTTCTGGGTGGCGGACGATGCTTGAGAAAAGCAAAACGATGATCGTGGAAG
CGACCGACAAGCTGCTCGATTTGGCGATTGGAGGTACGGCGGTCGGCACAGGGCTTAATGCGCCGCCATCATTTGGCGAA
CAAGTGGCCAAACAGTTGCACGCCCAAACCGGCTATCCATTCCGCTCAGCAACAAATAAATTTCACGCGTTAACAAGCCA
TGATGAGATCGTTTACGTTCATGGGGCGTTGAAGGCGCTTGCGGCTGATTTGATGAAAATCGCTAACGATATCCGTTGGC
TAGCGAGCGGGCCGCGTTCCGGGTTTGGGGAAATCGTGATTCCGTCGAATGAACCGGGCAGCTCAATCATGCCGGGTAAA
GTGAATCCGACGCAAAGCGAGGCGATGACGATGGTTGCCGTGCAAGTGTTCGGCAATGATGCTGCGATCGGTTTTGCGGC
AAGTCAAGGTAATTTTCAATTAAACGTGTTCAAACCGGTCATCGCTTATAACGCCATTCAGTCGGTGCAGTTGCTTGGCG
ATGCCATCCGCTCGTTTGATGAGCGATGTGCTCAAGGGTTAGAGGCAAATGAAACGAAAATGAAAGAGTACGTGGAGCGC
TCGCTGATGCTGGTGACGGCATTAAGCCCGCATATCGGCTATGACAAAGCCGCGGAAATCGCTAAGCTTGCGCATCGCGA
AGGATTGACGCTGAAAGAAGCGGCGTTGCAGACTGGGTATGTGACGGCCAAACAGTACGAGGAATGGGTAAGACCGGAGA
AGATGATTTAA

Upstream 100 bases:

>100_bases
TAGAGGTTGTAGAAGAAAATGAAGTTTTTCGCCGGCCTTCTGTGCCAAAATGGGAATACACATGTAGTGCAGGAATACCT
AAACAAAGGAGGACGACGTG

Downstream 100 bases:

>100_bases
CGGAACAAGACGATGAGTAGATAAGACTGGAGAGAATGGGTTAGCCAAAAACGCTCATCCCCTTTAAGCGGGATGAGCGT
TTTTTAGTTGGAGCAGCCTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MNERIERDSLGEVRVPADKYWGAQTERSRQNFRIGKETMPLELIYAYAELKKAAAIVNEQAGKLSEAKRQAIVTACDEIL
AGQWDAHFPLVVWQTGSGTQTNMNVNEVVARRANELLPDGEERIHPNDDVNMSQSSNDTFPTVMHIAIYTKIQTHLLPAI
DRLIGTFAAKERRYEKTIKVGRTHLQDATPLTFGQEISGWRTMLEKSKTMIVEATDKLLDLAIGGTAVGTGLNAPPSFGE
QVAKQLHAQTGYPFRSATNKFHALTSHDEIVYVHGALKALAADLMKIANDIRWLASGPRSGFGEIVIPSNEPGSSIMPGK
VNPTQSEAMTMVAVQVFGNDAAIGFAASQGNFQLNVFKPVIAYNAIQSVQLLGDAIRSFDERCAQGLEANETKMKEYVER
SLMLVTALSPHIGYDKAAEIAKLAHREGLTLKEAALQTGYVTAKQYEEWVRPEKMI

Sequences:

>Translated_456_residues
MNERIERDSLGEVRVPADKYWGAQTERSRQNFRIGKETMPLELIYAYAELKKAAAIVNEQAGKLSEAKRQAIVTACDEIL
AGQWDAHFPLVVWQTGSGTQTNMNVNEVVARRANELLPDGEERIHPNDDVNMSQSSNDTFPTVMHIAIYTKIQTHLLPAI
DRLIGTFAAKERRYEKTIKVGRTHLQDATPLTFGQEISGWRTMLEKSKTMIVEATDKLLDLAIGGTAVGTGLNAPPSFGE
QVAKQLHAQTGYPFRSATNKFHALTSHDEIVYVHGALKALAADLMKIANDIRWLASGPRSGFGEIVIPSNEPGSSIMPGK
VNPTQSEAMTMVAVQVFGNDAAIGFAASQGNFQLNVFKPVIAYNAIQSVQLLGDAIRSFDERCAQGLEANETKMKEYVER
SLMLVTALSPHIGYDKAAEIAKLAHREGLTLKEAALQTGYVTAKQYEEWVRPEKMI
>Mature_456_residues
MNERIERDSLGEVRVPADKYWGAQTERSRQNFRIGKETMPLELIYAYAELKKAAAIVNEQAGKLSEAKRQAIVTACDEIL
AGQWDAHFPLVVWQTGSGTQTNMNVNEVVARRANELLPDGEERIHPNDDVNMSQSSNDTFPTVMHIAIYTKIQTHLLPAI
DRLIGTFAAKERRYEKTIKVGRTHLQDATPLTFGQEISGWRTMLEKSKTMIVEATDKLLDLAIGGTAVGTGLNAPPSFGE
QVAKQLHAQTGYPFRSATNKFHALTSHDEIVYVHGALKALAADLMKIANDIRWLASGPRSGFGEIVIPSNEPGSSIMPGK
VNPTQSEAMTMVAVQVFGNDAAIGFAASQGNFQLNVFKPVIAYNAIQSVQLLGDAIRSFDERCAQGLEANETKMKEYVER
SLMLVTALSPHIGYDKAAEIAKLAHREGLTLKEAALQTGYVTAKQYEEWVRPEKMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=55.7734204793028, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=58.3333333333333, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.3947939262473, Blast_Score=314, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=54.4662309368192, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=53.5384615384615, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324993, Length=457, Percent_Identity=55.5798687089716, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=52.5054466230937, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=52.5054466230937, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=51.6268980477223, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=51.7391304347826, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=46.7532467532467, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50270; Mature: 50270

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERIERDSLGEVRVPADKYWGAQTERSRQNFRIGKETMPLELIYAYAELKKAAAIVNEQ
CCCCCCCCCCCCEECCHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGKLSEAKRQAIVTACDEILAGQWDAHFPLVVWQTGSGTQTNMNVNEVVARRANELLPDG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
EERIHPNDDVNMSQSSNDTFPTVMHIAIYTKIQTHLLPAIDRLIGTFAAKERRYEKTIKV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEISGWRTMLEKSKTMIVEATDKLLDLAIGGTAVGTGLNAPPSFGE
HHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCHHCCCCCCCCCHHHH
QVAKQLHAQTGYPFRSATNKFHALTSHDEIVYVHGALKALAADLMKIANDIRWLASGPRS
HHHHHHHHHCCCCCHHHCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFGEIVIPSNEPGSSIMPGKVNPTQSEAMTMVAVQVFGNDAAIGFAASQGNFQLNVFKPV
CCCCEEECCCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCEEEEEECCCCEEEEEHHHH
IAYNAIQSVQLLGDAIRSFDERCAQGLEANETKMKEYVERSLMLVTALSPHIGYDKAAEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AKLAHREGLTLKEAALQTGYVTAKQYEEWVRPEKMI
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNERIERDSLGEVRVPADKYWGAQTERSRQNFRIGKETMPLELIYAYAELKKAAAIVNEQ
CCCCCCCCCCCCEECCHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AGKLSEAKRQAIVTACDEILAGQWDAHFPLVVWQTGSGTQTNMNVNEVVARRANELLPDG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
EERIHPNDDVNMSQSSNDTFPTVMHIAIYTKIQTHLLPAIDRLIGTFAAKERRYEKTIKV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEISGWRTMLEKSKTMIVEATDKLLDLAIGGTAVGTGLNAPPSFGE
HHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCHHCCCCCCCCCHHHH
QVAKQLHAQTGYPFRSATNKFHALTSHDEIVYVHGALKALAADLMKIANDIRWLASGPRS
HHHHHHHHHCCCCCHHHCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFGEIVIPSNEPGSSIMPGKVNPTQSEAMTMVAVQVFGNDAAIGFAASQGNFQLNVFKPV
CCCCEEECCCCCCCCCCCCCCCCCHHHHHEEEEEEEECCCCEEEEEECCCCEEEEEHHHH
IAYNAIQSVQLLGDAIRSFDERCAQGLEANETKMKEYVERSLMLVTALSPHIGYDKAAEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AKLAHREGLTLKEAALQTGYVTAKQYEEWVRPEKMI
HHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]