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The map label for this gene is ddl

Identifier: 138893874

GI number: 138893874

Start: 211720

End: 212814

Strand: Direct

Name: ddl

Synonym: GTNG_0198

Alternate gene names: 138893874

Gene position: 211720-212814 (Clockwise)

Preceding gene: 138893873

Following gene: 138893875

Centisome position: 5.96

GC content: 46.39

Gene sequence:

>1095_bases
ATGAAAACGAGAGTTGGAGTGTTATACGGCGGTAAATCGCCGGAACACCAAGTGTCTTTGTCGACAGCGAGGGCGGTCAT
GAACGCCATTGATCCTCATAAATTTGACGTTATTCCGATTTATATTACACCAGAAGGACAATGGATTAAAGGAAAACGAT
TGACTGGAACGGTTGAAGAAGTGAAGCAGCTGCAGTTCACTTCGACAGCGACCGCGATGATCCCTGTGTCTTTAAACCAG
GTTCCTGCATCGGGTTCTGCAACTGAGAGCGACGAGGAAACCATTGATGTGATTTTCCCGCTTTTGCATGGGCCAAACGG
CGAAGATGGAACGGTACAAGGGCTGCTTGAAATGCTCAACCTCCCATATGTTGGAAATGGGGTGCTCGCTTCTGCTGTTG
GCATGGATAAAGTGGTGATGAAAAACTTGTTTGCCCAAGCTGGGCTGCGCCAAGCGAAGTATGTGTCAGTGACGAAATAT
GAATGGAAAAAAGGCGGAGAAGCAGTGTATGACCGAATCGAACAAGAGCTTGGCTACCCGTGCTTCGTCAAACCGGCCAA
CGCTGGATCGAGCGTCGGTATTTCCAAATGCAAACAGCGTGACGATTTAAAAACAGCGTTTGCTGAGGCATTTAAATACG
ATCGGAAAATTATTATTGAGGAATCTATTGTCGGTCGGGAAATTGAGATTGGCGTTATCGGCAATGACGAGCCGATTTGT
TCGGTTGCTGGAGAAATTGTACCGAAAAAAGAATTTTACGACTATGAAGCGAAATATGAAGACGGGCAAACGGAATTAAT
TATTCCTGCCAATGTGACAGAAGAGCAGTATGAGACGATCAAATCGATGGCCATTGCTGCGTTTAAAGCGCTCGACTTGT
CTGGACTGGCACGCGTCGACTTTTTCCTTGCCGAAGACGGTACTGTTTATATTAACGAAGTCAATACGATGCCGGGGTTT
ACGCCGTACAGCATGTTTCCGCTCCTTTGGCAACATAGCGGCGTGCCGTACTCGGAATTGATCGAACGCCTTATTGCATT
GGCATTGGAACGACATCAAGAAAAGCAGATGATTACGTACACATTTGAAAAGTAA

Upstream 100 bases:

>100_bases
GGTGGCGAAACAACCTGCATCGTACATATAAAATATCAGACCGTTGGGCGTGAAACGTGTTACAATAGGAACGATGGCCA
AGGAAAGAGGAGGAACGATA

Downstream 100 bases:

>100_bases
AAGAGGGTGAGAGCGGATGATGAAACGGACGGTGCAGCAAATTGCTGAGATGACCGGCGGCCGGTACGCGAATCCGGAGT
GGGGGAATATTGCTGTCAGC

Product: D-alanyl-alanine synthetase A

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEEVKQLQFTSTATAMIPVSLNQ
VPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLNLPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKY
EWKKGGEAVYDRIEQELGYPCFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPIC
SVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVDFFLAEDGTVYINEVNTMPGF
TPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITYTFEK

Sequences:

>Translated_364_residues
MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEEVKQLQFTSTATAMIPVSLNQ
VPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLNLPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKY
EWKKGGEAVYDRIEQELGYPCFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPIC
SVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVDFFLAEDGTVYINEVNTMPGF
TPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITYTFEK
>Mature_364_residues
MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEEVKQLQFTSTATAMIPVSLNQ
VPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLNLPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKY
EWKKGGEAVYDRIEQELGYPCFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPIC
SVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVDFFLAEDGTVYINEVNTMPGF
TPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITYTFEK

Specific function: Cell wall formation

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1786579, Length=371, Percent_Identity=43.3962264150943, Blast_Score=303, Evalue=9e-84,
Organism=Escherichia coli, GI1786280, Length=351, Percent_Identity=33.6182336182336, Blast_Score=195, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDL_GEOTN (A4IJS8)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124327.1
- ProteinModelPortal:   A4IJS8
- SMR:   A4IJS8
- STRING:   A4IJS8
- GeneID:   4965051
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0198
- NMPDR:   fig|420246.5.peg.197
- eggNOG:   COG1181
- HOGENOM:   HBG427092
- OMA:   FTDISMY
- PhylomeDB:   A4IJS8
- ProtClustDB:   PRK01966
- BioCyc:   GTHE420246:GTNG_0198-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00047
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR01205

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; SSF52440 PreATP-grasp-like

EC number: =6.3.2.4

Molecular weight: Translated: 40300; Mature: 40300

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEE
CCCEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHH
VKQLQFTSTATAMIPVSLNQVPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLN
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHCCCCCCCHHHHHHHHHHC
LPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKYEWKKGGEAVYDRIEQELGYP
CCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHHHHHCCCC
CFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPIC
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCHH
SVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVD
HHHHCCCCCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
FFLAEDGTVYINEVNTMPGFTPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITY
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
TFEK
EECC
>Mature Secondary Structure
MKTRVGVLYGGKSPEHQVSLSTARAVMNAIDPHKFDVIPIYITPEGQWIKGKRLTGTVEE
CCCEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHH
VKQLQFTSTATAMIPVSLNQVPASGSATESDEETIDVIFPLLHGPNGEDGTVQGLLEMLN
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHCCCCCCCHHHHHHHHHHC
LPYVGNGVLASAVGMDKVVMKNLFAQAGLRQAKYVSVTKYEWKKGGEAVYDRIEQELGYP
CCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHHHHHCCCC
CFVKPANAGSSVGISKCKQRDDLKTAFAEAFKYDRKIIIEESIVGREIEIGVIGNDEPIC
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCHH
SVAGEIVPKKEFYDYEAKYEDGQTELIIPANVTEEQYETIKSMAIAAFKALDLSGLARVD
HHHHCCCCCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
FFLAEDGTVYINEVNTMPGFTPYSMFPLLWQHSGVPYSELIERLIALALERHQEKQMITY
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
TFEK
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA