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The map label for this gene is mmgC [H]

Identifier: 138893854

GI number: 138893854

Start: 191456

End: 192616

Strand: Direct

Name: mmgC [H]

Synonym: GTNG_0178

Alternate gene names: 138893854

Gene position: 191456-192616 (Clockwise)

Preceding gene: 138893853

Following gene: 138893856

Centisome position: 5.39

GC content: 49.87

Gene sequence:

>1161_bases
ATGGAGTTTACGTTACCAGCCGAGATTGAATTTTTGAAAGAAAACGTGCGCAAGTTTGTCAGAGAAGTTGTTGAACCGGT
GGCGATGGATATTGAGGAAAACGACCACATTCCAGAAGATATTATCGAAAAATCGAAAGAAATGGGCTTGTTCGGTTTAA
GTATTCCGGAAGAGTACGGCGGCCTCGGCTTGTCGATGGTCGGCAAATGCGCCATTTACGAAGAGCTCGGCAAAACGCAT
AATGGCTATACGACGTTAATTGGCGCCCATACTGGCATCGGCACCGTCGGTATCGTCGAGCTTGGCACGGAGGAACAAAA
GCAGCGCTACTTGCCGAAAATGGCGACAGGGGAATGGATTGGTGCTTTTGCTCTCACTGAACCGAGCGCCGGCTCAAACG
CTGCTGCCTTGAAAACGACCGCCGTCCGCAAAGGCGACCGCTACATTATTAATGGCTCGAAACATTATATTACAAACGCC
GTTGACGCCCACGTGTTCACGGTGATGGCCGTCACTGATCCGTCGAAAGGTCCGAAAGGCATCACTTCGTTTATCGTGGA
AAAGGATTTTCCAGGGTTTACGATCGGCAATGTTGAACGCAAAATGGGGCTGCGTGGGTCACATTCGGCTGAGTTGTTTT
TTGACAACTTGGAAGTGCCGGTCGAAAACGTGCTTGGAAAAGAAGGAGAGGGCTATATCAACGCTTTGAAAATTTTAGCG
AACGGTCGCGCCGGTCTTGCCGCCCGCAACCTCGGTTCATGCATCCGCCTGCTCGAATATTGCATGGAATACGCCGAGCA
GCGTGAACAGTTCGGCAAGCCGATCATCGAGCAACAGGCGATTCAACATATGCTGGCGGAAATGAGCATGTTAATTGAAG
TGCTGCGCTCGACGGTCTATCGCGTTGCCTGGATGGTTGACCAAAAGATGCGTGTCGTCAAAGAAGCAGCCATCGCAAAA
CTGTTCGGTTCAGAAGTGTACAACAAAATCGCCGACATGGCCGTGCAAATTCACGGTGGCCTCGGCTATATGAAAGACTA
TCCAATCGAACGCTACTTCCGTGATGCCCGCATTACAAAAATTTATGAAGGCACCTCGGAAATTCAACGCAACATCATTG
CGAACGAACTGCGGAAAGAATACGGAAAAGTGCGGGTGTAA

Upstream 100 bases:

>100_bases
AGAACGTATCGACAAGCAGCAAAGCTTTTAGGTGTTGATGCGTCCACGCTCGTGCGCAAGGCACAAAAGTACAAAATCAA
ATCATTGGGAGGAGAAGACG

Downstream 100 bases:

>100_bases
ATGAAAACACTGTGTGCATTTGTATTTGCCAAAGGTGAAGGTATTGGATGAAATCGTTGCATTCGTGATTACGGTCCAGG
TATAAATGTGTTGCTTGTCA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MEFTLPAEIEFLKENVRKFVREVVEPVAMDIEENDHIPEDIIEKSKEMGLFGLSIPEEYGGLGLSMVGKCAIYEELGKTH
NGYTTLIGAHTGIGTVGIVELGTEEQKQRYLPKMATGEWIGAFALTEPSAGSNAAALKTTAVRKGDRYIINGSKHYITNA
VDAHVFTVMAVTDPSKGPKGITSFIVEKDFPGFTIGNVERKMGLRGSHSAELFFDNLEVPVENVLGKEGEGYINALKILA
NGRAGLAARNLGSCIRLLEYCMEYAEQREQFGKPIIEQQAIQHMLAEMSMLIEVLRSTVYRVAWMVDQKMRVVKEAAIAK
LFGSEVYNKIADMAVQIHGGLGYMKDYPIERYFRDARITKIYEGTSEIQRNIIANELRKEYGKVRV

Sequences:

>Translated_386_residues
MEFTLPAEIEFLKENVRKFVREVVEPVAMDIEENDHIPEDIIEKSKEMGLFGLSIPEEYGGLGLSMVGKCAIYEELGKTH
NGYTTLIGAHTGIGTVGIVELGTEEQKQRYLPKMATGEWIGAFALTEPSAGSNAAALKTTAVRKGDRYIINGSKHYITNA
VDAHVFTVMAVTDPSKGPKGITSFIVEKDFPGFTIGNVERKMGLRGSHSAELFFDNLEVPVENVLGKEGEGYINALKILA
NGRAGLAARNLGSCIRLLEYCMEYAEQREQFGKPIIEQQAIQHMLAEMSMLIEVLRSTVYRVAWMVDQKMRVVKEAAIAK
LFGSEVYNKIADMAVQIHGGLGYMKDYPIERYFRDARITKIYEGTSEIQRNIIANELRKEYGKVRV
>Mature_386_residues
MEFTLPAEIEFLKENVRKFVREVVEPVAMDIEENDHIPEDIIEKSKEMGLFGLSIPEEYGGLGLSMVGKCAIYEELGKTH
NGYTTLIGAHTGIGTVGIVELGTEEQKQRYLPKMATGEWIGAFALTEPSAGSNAAALKTTAVRKGDRYIINGSKHYITNA
VDAHVFTVMAVTDPSKGPKGITSFIVEKDFPGFTIGNVERKMGLRGSHSAELFFDNLEVPVENVLGKEGEGYINALKILA
NGRAGLAARNLGSCIRLLEYCMEYAEQREQFGKPIIEQQAIQHMLAEMSMLIEVLRSTVYRVAWMVDQKMRVVKEAAIAK
LFGSEVYNKIADMAVQIHGGLGYMKDYPIERYFRDARITKIYEGTSEIQRNIIANELRKEYGKVRV

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=40.2116402116402, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=38.7267904509284, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=43.4447300771208, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=43.4447300771208, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=45.4054054054054, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=41.8230563002681, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=41.8230563002681, Blast_Score=277, Evalue=9e-75,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=34.9081364829396, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=36.0742705570292, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI7656849, Length=363, Percent_Identity=33.6088154269972, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=35.9420289855072, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=29.7872340425532, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=29.7752808988764, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI211971008, Length=352, Percent_Identity=29.5454545454545, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI48976061, Length=352, Percent_Identity=29.5454545454545, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI38505218, Length=389, Percent_Identity=28.2776349614396, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI218563752, Length=294, Percent_Identity=25.8503401360544, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=30.1047120418848, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=32.3907455012853, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081702, Length=366, Percent_Identity=26.5027322404372, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=27.2058823529412, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=40.1041666666667, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=39.8921832884097, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=40, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=387, Percent_Identity=39.0180878552972, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=40.0544959128065, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=38.0829015544041, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=37.7952755905512, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=44.3661971830986, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=33.0666666666667, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=39.8089171974522, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=40.8695652173913, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=30.1333333333333, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=365, Percent_Identity=30.6849315068493, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=266, Percent_Identity=33.0827067669173, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=368, Percent_Identity=29.6195652173913, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=33.8775510204082, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17562446, Length=353, Percent_Identity=28.328611898017, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=180, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17540912, Length=335, Percent_Identity=22.9850746268657, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=302, Percent_Identity=24.1721854304636, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=302, Percent_Identity=24.1721854304636, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=40.3225806451613, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=37.6623376623377, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=38.5026737967914, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=40.7407407407407, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI281363737, Length=368, Percent_Identity=41.304347826087, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=37.0757180156658, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.1777188328912, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45550141, Length=216, Percent_Identity=27.3148148148148, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473076, Length=243, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652780, Length=328, Percent_Identity=23.780487804878, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43017; Mature: 43017

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTLPAEIEFLKENVRKFVREVVEPVAMDIEENDHIPEDIIEKSKEMGLFGLSIPEEYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEECCCCHHHC
GLGLSMVGKCAIYEELGKTHNGYTTLIGAHTGIGTVGIVELGTEEQKQRYLPKMATGEWI
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCCCCCCHH
GAFALTEPSAGSNAAALKTTAVRKGDRYIINGSKHYITNAVDAHVFTVMAVTDPSKGPKG
EEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHEEEEEEEEECCCCCCCH
ITSFIVEKDFPGFTIGNVERKMGLRGSHSAELFFDNLEVPVENVLGKEGEGYINALKILA
HHHHHHHCCCCCCEECCHHHHHCCCCCCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHH
NGRAGLAARNLGSCIRLLEYCMEYAEQREQFGKPIIEQQAIQHMLAEMSMLIEVLRSTVY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAWMVDQKMRVVKEAAIAKLFGSEVYNKIADMAVQIHGGLGYMKDYPIERYFRDARITK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
IYEGTSEIQRNIIANELRKEYGKVRV
HHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFTLPAEIEFLKENVRKFVREVVEPVAMDIEENDHIPEDIIEKSKEMGLFGLSIPEEYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEECCCCHHHC
GLGLSMVGKCAIYEELGKTHNGYTTLIGAHTGIGTVGIVELGTEEQKQRYLPKMATGEWI
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCCCCCCHH
GAFALTEPSAGSNAAALKTTAVRKGDRYIINGSKHYITNAVDAHVFTVMAVTDPSKGPKG
EEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHEEEEEEEEECCCCCCCH
ITSFIVEKDFPGFTIGNVERKMGLRGSHSAELFFDNLEVPVENVLGKEGEGYINALKILA
HHHHHHHCCCCCCEECCHHHHHCCCCCCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHH
NGRAGLAARNLGSCIRLLEYCMEYAEQREQFGKPIIEQQAIQHMLAEMSMLIEVLRSTVY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAWMVDQKMRVVKEAAIAKLFGSEVYNKIADMAVQIHGGLGYMKDYPIERYFRDARITK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
IYEGTSEIQRNIIANELRKEYGKVRV
HHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]