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The map label for this gene is hemN [C]

Identifier: 126696835

GI number: 126696835

Start: 1266897

End: 1268120

Strand: Reverse

Name: hemN [C]

Synonym: P9301_14971

Alternate gene names: 126696835

Gene position: 1268120-1266897 (Counterclockwise)

Preceding gene: 126696842

Following gene: 126696828

Centisome position: 77.24

GC content: 32.6

Gene sequence:

>1224_bases
ATGAATAAGTTTCCAAGAAGTGCTTATGTGCACATTCCTTTTTGCCACAGAAGGTGTTTTTATTGTGATTTTGCAGTTAT
TCCATTAGGAAACGAAGTTGAAACTTTAAAAGGTTATGGAAGCAAAACAGTTCAGGAGTATTTGCAATTTTTATATAAAG
AAATATTGTCAATTAAGCATAAATCACCTCTATCGACAATTTATATAGGAGGTGGTACACCATCAATCTTAGATCCTGCC
CAAATCAAAGAATTGGTTAATCTTTTTAAAGAAAATTATGGAATTGACTATGGTGCTGAAATTACTATGGAGGTTGATCC
AGCAAGTTTTACTCAAGATGATCTTTTCGGATTCATAAATGCTGGGATAAATAGATTTAGTCTTGGAGTACAAAGTTTTA
ATAATCAGATACTTCAAAAGTCGGGAAGGCGTCATTTGAAAGAAGATGCAGTGAAATCTTGTTTATGGTTGAAGAGAGAA
TATGATAACGGGTTAATAAAAAGCTGGAGTCTAGATTTAATTCAAAACTTGCCACTAAGTGGATTTAAGGAATGGCAAGA
TGACTTAAAAAAAGCAATTACATTTTCACCACCTCATCTATCTATTTACGATTTAAATATTGAAGATGGCACTGTTTTTA
AAAAATTAATTAATTTAGGCAAATTAAAACTTCCAAGTGATGAAGAAGCTTTTAGAAATAGTGAATCAACACATTTAATT
TTAAAAAAATCAGGGTATTCAAGATATGAAATCTCAAACTATTGCCTTCCGCGACACCAATCGAGACATAATAGAGTTTA
TTGGAGTGGTTTAGGCTGGTGGAGTTTTGGTCAAGGTTCCACTAGTTCACCTTGGGGAGAAAAGTTTACTCGACCAAGAG
TTAGTAAAGAATATAAAGAATGGGTAACAAGACAAGACGAATTTAATTTAGATTCATCCCTAACTAATAAGGGGTTTGTT
TATAAAGAACTTGATGAGAAAATAATGTTGGGATTAAGACTTAAAGAGGGTGTAGATATCAAAGAAGTGTTTAAAGAGCA
AAACTGGGAAAACAAAAAATTGGAAAGCAACTTCAGTAAATTGGTTGAAGAATGGGAGAGATTTCTTGAAAGTGGACTAC
TAGTAAGAAAGGGGAATAGATTCTTTTTAAGTGAGCCTAATGGCATGGAACTTAGTAATCAAATTCTTGTCTCTATGTTT
AAGTGGTGGGATGAGATTAACTAA

Upstream 100 bases:

>100_bases
TCATATCTATAATCTACTAGGATTTATTAATTGAGTAAATAAGGATTTTATTTTTTTCGATCCTTAATACTTTTTTGGAG
CTTAAAAATGAATTTAGATT

Downstream 100 bases:

>100_bases
GCCTTTCAGAGTCTACCCATTCTTTTAATTTATCCTTAAATAATTTCTTTCCTTGGATAATTGGTTGGCAAAATGGGGGT
TGATCATCATTGAGGCCTAG

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNEVETLKGYGSKTVQEYLQFLYKEILSIKHKSPLSTIYIGGGTPSILDPA
QIKELVNLFKENYGIDYGAEITMEVDPASFTQDDLFGFINAGINRFSLGVQSFNNQILQKSGRRHLKEDAVKSCLWLKRE
YDNGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIEDGTVFKKLINLGKLKLPSDEEAFRNSESTHLI
LKKSGYSRYEISNYCLPRHQSRHNRVYWSGLGWWSFGQGSTSSPWGEKFTRPRVSKEYKEWVTRQDEFNLDSSLTNKGFV
YKELDEKIMLGLRLKEGVDIKEVFKEQNWENKKLESNFSKLVEEWERFLESGLLVRKGNRFFLSEPNGMELSNQILVSMF
KWWDEIN

Sequences:

>Translated_407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNEVETLKGYGSKTVQEYLQFLYKEILSIKHKSPLSTIYIGGGTPSILDPA
QIKELVNLFKENYGIDYGAEITMEVDPASFTQDDLFGFINAGINRFSLGVQSFNNQILQKSGRRHLKEDAVKSCLWLKRE
YDNGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIEDGTVFKKLINLGKLKLPSDEEAFRNSESTHLI
LKKSGYSRYEISNYCLPRHQSRHNRVYWSGLGWWSFGQGSTSSPWGEKFTRPRVSKEYKEWVTRQDEFNLDSSLTNKGFV
YKELDEKIMLGLRLKEGVDIKEVFKEQNWENKKLESNFSKLVEEWERFLESGLLVRKGNRFFLSEPNGMELSNQILVSMF
KWWDEIN
>Mature_407_residues
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNEVETLKGYGSKTVQEYLQFLYKEILSIKHKSPLSTIYIGGGTPSILDPA
QIKELVNLFKENYGIDYGAEITMEVDPASFTQDDLFGFINAGINRFSLGVQSFNNQILQKSGRRHLKEDAVKSCLWLKRE
YDNGLIKSWSLDLIQNLPLSGFKEWQDDLKKAITFSPPHLSIYDLNIEDGTVFKKLINLGKLKLPSDEEAFRNSESTHLI
LKKSGYSRYEISNYCLPRHQSRHNRVYWSGLGWWSFGQGSTSSPWGEKFTRPRVSKEYKEWVTRQDEFNLDSSLTNKGFV
YKELDEKIMLGLRLKEGVDIKEVFKEQNWENKKLESNFSKLVEEWERFLESGLLVRKGNRFFLSEPNGMELSNQILVSMF
KWWDEIN

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=273, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789325, Length=280, Percent_Identity=34.2857142857143, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082341, Length=259, Percent_Identity=31.6602316602317, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 47439; Mature: 47439

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNEVETLKGYGSKTVQEYLQFLYKEILSIKH
CCCCCCCCEEEEEHHHCEEEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KSPLSTIYIGGGTPSILDPAQIKELVNLFKENYGIDYGAEITMEVDPASFTQDDLFGFIN
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGINRFSLGVQSFNNQILQKSGRRHLKEDAVKSCLWLKREYDNGLIKSWSLDLIQNLPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GFKEWQDDLKKAITFSPPHLSIYDLNIEDGTVFKKLINLGKLKLPSDEEAFRNSESTHLI
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
LKKSGYSRYEISNYCLPRHQSRHNRVYWSGLGWWSFGQGSTSSPWGEKFTRPRVSKEYKE
EECCCCCEEECCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHCCCCHHHHHHH
WVTRQDEFNLDSSLTNKGFVYKELDEKIMLGLRLKEGVDIKEVFKEQNWENKKLESNFSK
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCHHHHHHHHH
LVEEWERFLESGLLVRKGNRFFLSEPNGMELSNQILVSMFKWWDEIN
HHHHHHHHHHCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKFPRSAYVHIPFCHRRCFYCDFAVIPLGNEVETLKGYGSKTVQEYLQFLYKEILSIKH
CCCCCCCCEEEEEHHHCEEEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCC
KSPLSTIYIGGGTPSILDPAQIKELVNLFKENYGIDYGAEITMEVDPASFTQDDLFGFIN
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
AGINRFSLGVQSFNNQILQKSGRRHLKEDAVKSCLWLKREYDNGLIKSWSLDLIQNLPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GFKEWQDDLKKAITFSPPHLSIYDLNIEDGTVFKKLINLGKLKLPSDEEAFRNSESTHLI
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCEEE
LKKSGYSRYEISNYCLPRHQSRHNRVYWSGLGWWSFGQGSTSSPWGEKFTRPRVSKEYKE
EECCCCCEEECCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHCCCCHHHHHHH
WVTRQDEFNLDSSLTNKGFVYKELDEKIMLGLRLKEGVDIKEVFKEQNWENKKLESNFSK
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCHHHHHHHHH
LVEEWERFLESGLLVRKGNRFFLSEPNGMELSNQILVSMFKWWDEIN
HHHHHHHHHHCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]