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The map label for this gene is neuC [H]

Identifier: 126696745

GI number: 126696745

Start: 1174224

End: 1175336

Strand: Reverse

Name: neuC [H]

Synonym: P9301_14071

Alternate gene names: 126696745

Gene position: 1175336-1174224 (Counterclockwise)

Preceding gene: 126696746

Following gene: 126696744

Centisome position: 71.58

GC content: 28.66

Gene sequence:

>1113_bases
ATGAAATCTAAAATAGCTGTTTTTACTTCTACGAGGGCTGAATATGGTTTATTAAGGAATCTATGCAAATTATTAGATTC
TGAAAAACTATTTCAACTTATAATCATTGTTACAGGAACACATTTAGAGGATGAGTATGGTTATACATGTGACCAGATTA
AAAAAGATGGATTCTCTAATCTTGAATTTATTCACCTATCAATTAAGGGAGATAAAAATGCTGCTGAAATCACAGCTGAG
TTAATAACAAAAATATCTAAGTTTTTTGAGGATTTCAATCCTGATTTTTTAATAGTCTTGGGTGATAGGTATGAGGCATT
AGGCGCTGTTTATTCGGCATTTTTAAAGAAAATAAAAATTATACATTTGCATGGTGGAGAAGTTACTTTTGGCTCTCTGG
ATAATGGGTTTAGGAATGCAATTAGTCAATTAGCCAATCTTCACTTTACTAGTTTAGAAAAACACACAAAGAATTTACTA
AATATGGGCGTAAATAAGAAAAATATATTTACCGTAGGGCCTATGATCAAAGATTTATTAAATTGCCATGAATCAATTAC
TCATAGTCAATTCGAAAAAAAACTTAATTTCAAATTTGATAAATTTAATATAATTCTGACATTCCATCCAGAAAGTTATA
TTTATGATTATGGTCTTGAGAAGTTAAAAAATATATTTAGAGTGATTCTTGAATTAGAGGCAAATGTACTTATTACATAC
CCAAATATAGATGAAGGTGGGGAAATAATTAAAACTGCTTTAATTAGATTTTCAGAGCGTAATAGTGATAGATGTTTCCT
TTATAAATCTCTTGGCTCTGATTTATATATTTCATCTTTAAAGTTATTTGATGTAGTAATTGGAAATTCCTCTAGTGGAA
TTATTGAGGCACCATTGATAGGAATACCTTCCTTAAATATTGGTGAAAGGCAAAAAGGAAGATCAACTTTTGGTAAGGTG
TCCAATCTAGATGGATCATATAAAGAAATGTATGAATCACTTAAAAAAATAAAGGAAGGGAAAACTCCTCTATCTCAACC
AAGGAATTTACAAATAGAAAGAAAATTACCAAGTTATGAAATAATTAAGATACTTAAAGAAATAATTAACTAA

Upstream 100 bases:

>100_bases
CCAGGTAATGGTTTAAGTCCAATGGAAATAGATAAGGTTATTGGAGCAGTAGCATCCAAGGATTATAAAGATGGAGATCT
AATATTAGATCTTAATTTAA

Downstream 100 bases:

>100_bases
GTTTGCAAATTAATATGATAAAAAATTTACTCAATAAAAATTATAAAAATTTATTTAAAAATAATCAATCTTACAATATT
TTAGAAAAAAAAAGTTTTTT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKSKIAVFTSTRAEYGLLRNLCKLLDSEKLFQLIIIVTGTHLEDEYGYTCDQIKKDGFSNLEFIHLSIKGDKNAAEITAE
LITKISKFFEDFNPDFLIVLGDRYEALGAVYSAFLKKIKIIHLHGGEVTFGSLDNGFRNAISQLANLHFTSLEKHTKNLL
NMGVNKKNIFTVGPMIKDLLNCHESITHSQFEKKLNFKFDKFNIILTFHPESYIYDYGLEKLKNIFRVILELEANVLITY
PNIDEGGEIIKTALIRFSERNSDRCFLYKSLGSDLYISSLKLFDVVIGNSSSGIIEAPLIGIPSLNIGERQKGRSTFGKV
SNLDGSYKEMYESLKKIKEGKTPLSQPRNLQIERKLPSYEIIKILKEIIN

Sequences:

>Translated_370_residues
MKSKIAVFTSTRAEYGLLRNLCKLLDSEKLFQLIIIVTGTHLEDEYGYTCDQIKKDGFSNLEFIHLSIKGDKNAAEITAE
LITKISKFFEDFNPDFLIVLGDRYEALGAVYSAFLKKIKIIHLHGGEVTFGSLDNGFRNAISQLANLHFTSLEKHTKNLL
NMGVNKKNIFTVGPMIKDLLNCHESITHSQFEKKLNFKFDKFNIILTFHPESYIYDYGLEKLKNIFRVILELEANVLITY
PNIDEGGEIIKTALIRFSERNSDRCFLYKSLGSDLYISSLKLFDVVIGNSSSGIIEAPLIGIPSLNIGERQKGRSTFGKV
SNLDGSYKEMYESLKKIKEGKTPLSQPRNLQIERKLPSYEIIKILKEIIN
>Mature_370_residues
MKSKIAVFTSTRAEYGLLRNLCKLLDSEKLFQLIIIVTGTHLEDEYGYTCDQIKKDGFSNLEFIHLSIKGDKNAAEITAE
LITKISKFFEDFNPDFLIVLGDRYEALGAVYSAFLKKIKIIHLHGGEVTFGSLDNGFRNAISQLANLHFTSLEKHTKNLL
NMGVNKKNIFTVGPMIKDLLNCHESITHSQFEKKLNFKFDKFNIILTFHPESYIYDYGLEKLKNIFRVILELEANVLITY
PNIDEGGEIIKTALIRFSERNSDRCFLYKSLGSDLYISSLKLFDVVIGNSSSGIIEAPLIGIPSLNIGERQKGRSTFGKV
SNLDGSYKEMYESLKKIKEGKTPLSQPRNLQIERKLPSYEIIKILKEIIN

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885285, Length=320, Percent_Identity=28.4375, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI298566312, Length=320, Percent_Identity=28.4375, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI190014632, Length=320, Percent_Identity=28.4375, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI298566325, Length=290, Percent_Identity=26.551724137931, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI298566315, Length=266, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42072; Mature: 42072

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKIAVFTSTRAEYGLLRNLCKLLDSEKLFQLIIIVTGTHLEDEYGYTCDQIKKDGFSN
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHEEEEEEEECCCCCCCCCCCHHHHHHCCCCC
LEFIHLSIKGDKNAAEITAELITKISKFFEDFNPDFLIVLGDRYEALGAVYSAFLKKIKI
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHEEE
IHLHGGEVTFGSLDNGFRNAISQLANLHFTSLEKHTKNLLNMGVNKKNIFTVGPMIKDLL
EEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
NCHESITHSQFEKKLNFKFDKFNIILTFHPESYIYDYGLEKLKNIFRVILELEANVLITY
HHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PNIDEGGEIIKTALIRFSERNSDRCFLYKSLGSDLYISSLKLFDVVIGNSSSGIIEAPLI
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHEEEEEEECCCCCCEEEECEE
GIPSLNIGERQKGRSTFGKVSNLDGSYKEMYESLKKIKEGKTPLSQPRNLQIERKLPSYE
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHH
IIKILKEIIN
HHHHHHHHHC
>Mature Secondary Structure
MKSKIAVFTSTRAEYGLLRNLCKLLDSEKLFQLIIIVTGTHLEDEYGYTCDQIKKDGFSN
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHEEEEEEEECCCCCCCCCCCHHHHHHCCCCC
LEFIHLSIKGDKNAAEITAELITKISKFFEDFNPDFLIVLGDRYEALGAVYSAFLKKIKI
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHEEE
IHLHGGEVTFGSLDNGFRNAISQLANLHFTSLEKHTKNLLNMGVNKKNIFTVGPMIKDLL
EEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
NCHESITHSQFEKKLNFKFDKFNIILTFHPESYIYDYGLEKLKNIFRVILELEANVLITY
HHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PNIDEGGEIIKTALIRFSERNSDRCFLYKSLGSDLYISSLKLFDVVIGNSSSGIIEAPLI
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHEEEEEEECCCCCCEEEECEE
GIPSLNIGERQKGRSTFGKVSNLDGSYKEMYESLKKIKEGKTPLSQPRNLQIERKLPSYE
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHH
IIKILKEIIN
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]