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The map label for this gene is spsE

Identifier: 126696746

GI number: 126696746

Start: 1175326

End: 1176351

Strand: Reverse

Name: spsE

Synonym: P9301_14081

Alternate gene names: NA

Gene position: 1176351-1175326 (Counterclockwise)

Preceding gene: 126696747

Following gene: 126696745

Centisome position: 71.65

GC content: 30.8

Gene sequence:

>1026_bases
ATGGCCACTAAAGTAATAGCTGAAGCGGGAGTAAATCATAATGGATCTTTAGATTTAGCTTTAAAGTTAGTTGAAGAAGC
TAAATTGTCTGGAGCTGATTCTATTAAGTTTCAGACTTTTAAAAGTGAATCCCTCGCTAGTTTTTCTGCCCCTCTAGCTC
AATATCAAAAAAAATCGAATTCTTATAAAAGTCAAATAGATATGCTTAAATCTTTAGAACTTACGGATAAGGATACAAAA
AGAATTTTTAGTTTTTGTAATGAAATTGGAATAGAGTTTATGTCATCTCCTTTTGGGGTTGATGAATTACATTTCCTTTT
AGATTTAGGAATGCTTTCAATAAAAATACCTTCTGGAGAAATTACTAATTATGCTCTCATTAGTGAAATAGGTAAATTCA
TCTCAGAAGGAAACATTAATGTTTTATTATCTACCGGTATGTCTAGTTTAGGGGATATTGAGGAAGCTTTATCTCTTTTA
AGATTTAAAGAGACCCTAGAAAGAATAACAATAATGCATTGTGTAAGTAGTTATCCTGCTCCAAATAAAGACTTAAATTT
AAAAGTATTGAGTACTTTGCAAAATTGCTTTGGTTGTAAAACAGGCTATTCGGATCATAGTGAAAATATAATTGCGCCGA
TTATTTCAATTGCACTAGGAGCATCTGCAATAGAGAAACATTTAACTCTTGATAAGGACCTGCCTGGTCCCGACCATAAA
GCGAGTATTACTCCTAAATTATTTGCAAAAATGGTTAGTGATATAAGAGCAACGGAGGTGATGTTAGGTAACAGTAGAAA
AGAAACAAAAGAAAGTGAAATTGAAAATAAATTAATAGCTAGGAGATCAATAAGAGCCTTTAATAATATTCAAAAAGGTT
CTTTAATCACAAAAAAAAATATAATCTTTCAAAGACCAGGTAATGGTTTAAGTCCAATGGAAATAGATAAGGTTATTGGA
GCAGTAGCATCCAAGGATTATAAAGATGGAGATCTAATATTAGATCTTAATTTAAATGAAATCTAA

Upstream 100 bases:

>100_bases
AAATTGGCCGTGAAAGTTTTATAGGAAGTAAAGTTATGATAAGGGAAGGTTTATCTCTTCCGAGGGGTACAATAATAAGT
GCCGGTAAGAGAGTAATGGG

Downstream 100 bases:

>100_bases
AATAGCTGTTTTTACTTCTACGAGGGCTGAATATGGTTTATTAAGGAATCTATGCAAATTATTAGATTCTGAAAAACTAT
TTCAACTTATAATCATTGTT

Product: sialic acid synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MATKVIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQTFKSESLASFSAPLAQYQKKSNSYKSQIDMLKSLELTDKDTK
RIFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGEITNYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLL
RFKETLERITIMHCVSSYPAPNKDLNLKVLSTLQNCFGCKTGYSDHSENIIAPIISIALGASAIEKHLTLDKDLPGPDHK
ASITPKLFAKMVSDIRATEVMLGNSRKETKESEIENKLIARRSIRAFNNIQKGSLITKKNIIFQRPGNGLSPMEIDKVIG
AVASKDYKDGDLILDLNLNEI

Sequences:

>Translated_341_residues
MATKVIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQTFKSESLASFSAPLAQYQKKSNSYKSQIDMLKSLELTDKDTK
RIFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGEITNYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLL
RFKETLERITIMHCVSSYPAPNKDLNLKVLSTLQNCFGCKTGYSDHSENIIAPIISIALGASAIEKHLTLDKDLPGPDHK
ASITPKLFAKMVSDIRATEVMLGNSRKETKESEIENKLIARRSIRAFNNIQKGSLITKKNIIFQRPGNGLSPMEIDKVIG
AVASKDYKDGDLILDLNLNEI
>Mature_340_residues
ATKVIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQTFKSESLASFSAPLAQYQKKSNSYKSQIDMLKSLELTDKDTKR
IFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGEITNYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLLR
FKETLERITIMHCVSSYPAPNKDLNLKVLSTLQNCFGCKTGYSDHSENIIAPIISIALGASAIEKHLTLDKDLPGPDHKA
SITPKLFAKMVSDIRATEVMLGNSRKETKESEIENKLIARRSIRAFNNIQKGSLITKKNIIFQRPGNGLSPMEIDKVIGA
VASKDYKDGDLILDLNLNEI

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=336, Percent_Identity=29.4642857142857, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357081, Length=254, Percent_Identity=32.6771653543307, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 37421; Mature: 37289

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKVIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQTFKSESLASFSAPLAQYQKKSN
CCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SYKSQIDMLKSLELTDKDTKRIFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHEEECCCCC
ITNYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLLRFKETLERITIMHCVSSYPA
CHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNKDLNLKVLSTLQNCFGCKTGYSDHSENIIAPIISIALGASAIEKHLTLDKDLPGPDHK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
ASITPKLFAKMVSDIRATEVMLGNSRKETKESEIENKLIARRSIRAFNNIQKGSLITKKN
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
IIFQRPGNGLSPMEIDKVIGAVASKDYKDGDLILDLNLNEI
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
ATKVIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQTFKSESLASFSAPLAQYQKKSN
CCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SYKSQIDMLKSLELTDKDTKRIFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHEEECCCCC
ITNYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLLRFKETLERITIMHCVSSYPA
CHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNKDLNLKVLSTLQNCFGCKTGYSDHSENIIAPIISIALGASAIEKHLTLDKDLPGPDHK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
ASITPKLFAKMVSDIRATEVMLGNSRKETKESEIENKLIARRSIRAFNNIQKGSLITKKN
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
IIFQRPGNGLSPMEIDKVIGAVASKDYKDGDLILDLNLNEI
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]