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The map label for this gene is ugd [H]

Identifier: 126696736

GI number: 126696736

Start: 1165603

End: 1167018

Strand: Reverse

Name: ugd [H]

Synonym: P9301_13981

Alternate gene names: 126696736

Gene position: 1167018-1165603 (Counterclockwise)

Preceding gene: 126696737

Following gene: 126696734

Centisome position: 71.08

GC content: 31.5

Gene sequence:

>1416_bases
ATGGATAATTCAAATGTAAACATTGTGAAGAACATTTGTTGCCTTGGGGCCGGTTACGTTGGAGGACCTACTATGGCAGT
TTTAGCTTCAAAATGTCCTAATATAAAAGTCACTGTTGTTGATATTGATTTAAATAAGATTGCTGCGTGGAATAATCAAA
ATTTGGATAAGCTTCCAGTTTTTGAGCCAGGTTTAGATAAAATTATTTCAAAGGTTAGAGGCAAAAATCTATTTTTTTCT
AATGATATTGAAAAATCAATTAAAGACTCAGAATTGGTTTTCATTTCAGTAAATACGCCAACAAAAATAAAAGGATTTGG
AGCATTTTATGCAAGTGATTTGAAGTGGGTTGAATCAAGTGCTAGGCAAGTTGCTAAATATGCGAGCGGTCATACGATAG
TTGTAGAGAAAAGTACAGTTCCTGTTAAAACTGCTGAATTAATAAAAAAAATTTTAAAGAGCTCTAATAGTTCCAACAAA
AAAAAAGAAAATTCTTTTTCTGTATTATCAAGTCCAGAGTTTCTTGCAGAGGGAAGTGCTATTAATGATTTGATAAATCC
TGATAGAGTTTTGATTGGAGGTGACAATGAAGAATCAATAAAAAAACTTTGTGCAATATATGAAAATTGGATCCCTAAAG
AAAAAATTCTGGTTACAAATATATGGAGCAGTGAATTGTCTAAATTAACAGCAAATGCTTTTTTAGCCCAAAGAATAAGT
TCAATTAATTCAATTGCGGCTATTTGCGAAAAGACTGGTGCAGAAATCAAAGAGGTTTCTGCTGCTATTGGTTCCGATAC
AAGGATTGGAAATAAATTCTTATTATCAAGTCCTGGTTTTGGCGGGAGCTGCTTCCAAAAAGATATTTTAAATCTTGTTT
ATTTAAGTAGATATTATGGTTTAGATCATGTCGCAAAATATTGGGAAAATGTAATTTCTTTGAATAATTGGCAAAAGGAA
CGTATATCTGAAGTAATAGTAGATAAATTATTTGGAACAATAACAGGTAAAAAGATTGTACTTTTGGGATTTTCTTTTAA
AGCTAATACAAATGATACAAGAGAATCTCCATCAATAGATATTGCAAAAAATTTGCTAGAAAATGGTGCAAAATTAGTAA
TTAATGATCCAAGAGTAAGTAATAAACAAATTGAATTAGCGTTAAATCAGCCATCAAAAGAAATAGATCACAATGTAGAA
GGTATTTGGTATTATGAGGAAGACATTTTGGAGGCTGTTAAATCAGCCGATGCAATAGTTATCTTAACTGAGTGGCAAGA
ATATAAGAATTTAAATTGGGAATTAATATCCAAGAGTATGAGAAAGCCTTCTTGGGTTTTTGATACAAGAGGCATAATTA
ATCGTAGGGAAATCGATGTAACTCCTATTAATCTATGGACGCTTGGGAAAGGGTAG

Upstream 100 bases:

>100_bases
GCTAAATGGTTCGAAAATTACTATGAGCATTAAATATAATTTTATTTAATTATGCAACCAAATTCCTTCCCTATATTAAA
GTATTTTAAACATTAATTTT

Downstream 100 bases:

>100_bases
ATTTAATAATTTTCATTTATTGTTTGTCTTAAACCTGCTAATAATATCCAAAAAATCATACTTATTCTTCCATCGTAGTA
TTGAATATCAACTAATTGAG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MDNSNVNIVKNICCLGAGYVGGPTMAVLASKCPNIKVTVVDIDLNKIAAWNNQNLDKLPVFEPGLDKIISKVRGKNLFFS
NDIEKSIKDSELVFISVNTPTKIKGFGAFYASDLKWVESSARQVAKYASGHTIVVEKSTVPVKTAELIKKILKSSNSSNK
KKENSFSVLSSPEFLAEGSAINDLINPDRVLIGGDNEESIKKLCAIYENWIPKEKILVTNIWSSELSKLTANAFLAQRIS
SINSIAAICEKTGAEIKEVSAAIGSDTRIGNKFLLSSPGFGGSCFQKDILNLVYLSRYYGLDHVAKYWENVISLNNWQKE
RISEVIVDKLFGTITGKKIVLLGFSFKANTNDTRESPSIDIAKNLLENGAKLVINDPRVSNKQIELALNQPSKEIDHNVE
GIWYYEEDILEAVKSADAIVILTEWQEYKNLNWELISKSMRKPSWVFDTRGIINRREIDVTPINLWTLGKG

Sequences:

>Translated_471_residues
MDNSNVNIVKNICCLGAGYVGGPTMAVLASKCPNIKVTVVDIDLNKIAAWNNQNLDKLPVFEPGLDKIISKVRGKNLFFS
NDIEKSIKDSELVFISVNTPTKIKGFGAFYASDLKWVESSARQVAKYASGHTIVVEKSTVPVKTAELIKKILKSSNSSNK
KKENSFSVLSSPEFLAEGSAINDLINPDRVLIGGDNEESIKKLCAIYENWIPKEKILVTNIWSSELSKLTANAFLAQRIS
SINSIAAICEKTGAEIKEVSAAIGSDTRIGNKFLLSSPGFGGSCFQKDILNLVYLSRYYGLDHVAKYWENVISLNNWQKE
RISEVIVDKLFGTITGKKIVLLGFSFKANTNDTRESPSIDIAKNLLENGAKLVINDPRVSNKQIELALNQPSKEIDHNVE
GIWYYEEDILEAVKSADAIVILTEWQEYKNLNWELISKSMRKPSWVFDTRGIINRREIDVTPINLWTLGKG
>Mature_471_residues
MDNSNVNIVKNICCLGAGYVGGPTMAVLASKCPNIKVTVVDIDLNKIAAWNNQNLDKLPVFEPGLDKIISKVRGKNLFFS
NDIEKSIKDSELVFISVNTPTKIKGFGAFYASDLKWVESSARQVAKYASGHTIVVEKSTVPVKTAELIKKILKSSNSSNK
KKENSFSVLSSPEFLAEGSAINDLINPDRVLIGGDNEESIKKLCAIYENWIPKEKILVTNIWSSELSKLTANAFLAQRIS
SINSIAAICEKTGAEIKEVSAAIGSDTRIGNKFLLSSPGFGGSCFQKDILNLVYLSRYYGLDHVAKYWENVISLNNWQKE
RISEVIVDKLFGTITGKKIVLLGFSFKANTNDTRESPSIDIAKNLLENGAKLVINDPRVSNKQIELALNQPSKEIDHNVE
GIWYYEEDILEAVKSADAIVILTEWQEYKNLNWELISKSMRKPSWVFDTRGIINRREIDVTPINLWTLGKG

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=468, Percent_Identity=53.2051282051282, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI296040438, Length=371, Percent_Identity=52.0215633423181, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI296040443, Length=331, Percent_Identity=52.8700906344411, Blast_Score=348, Evalue=8e-96,
Organism=Escherichia coli, GI48994968, Length=457, Percent_Identity=25.164113785558, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788340, Length=371, Percent_Identity=25.6064690026954, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=53.5483870967742, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=53.0172413793103, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 52345; Mature: 52345

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNSNVNIVKNICCLGAGYVGGPTMAVLASKCPNIKVTVVDIDLNKIAAWNNQNLDKLPV
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEEHHHEECCCCCCCCCCCC
FEPGLDKIISKVRGKNLFFSNDIEKSIKDSELVFISVNTPTKIKGFGAFYASDLKWVESS
CCCCHHHHHHHHCCCCCEECCCHHHCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHH
ARQVAKYASGHTIVVEKSTVPVKTAELIKKILKSSNSSNKKKENSFSVLSSPEFLAEGSA
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHCCCH
INDLINPDRVLIGGDNEESIKKLCAIYENWIPKEKILVTNIWSSELSKLTANAFLAQRIS
HHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SINSIAAICEKTGAEIKEVSAAIGSDTRIGNKFLLSSPGFGGSCFQKDILNLVYLSRYYG
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
LDHVAKYWENVISLNNWQKERISEVIVDKLFGTITGKKIVLLGFSFKANTNDTRESPSID
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHH
IAKNLLENGAKLVINDPRVSNKQIELALNQPSKEIDHNVEGIWYYEEDILEAVKSADAIV
HHHHHHHCCCEEEEECCCCCCCEEEEEECCCCHHHCCCCCEEEEEHHHHHHHHHCCCEEE
ILTEWQEYKNLNWELISKSMRKPSWVFDTRGIINRREIDVTPINLWTLGKG
EEECCHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEECCCC
>Mature Secondary Structure
MDNSNVNIVKNICCLGAGYVGGPTMAVLASKCPNIKVTVVDIDLNKIAAWNNQNLDKLPV
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEEHHHEECCCCCCCCCCCC
FEPGLDKIISKVRGKNLFFSNDIEKSIKDSELVFISVNTPTKIKGFGAFYASDLKWVESS
CCCCHHHHHHHHCCCCCEECCCHHHCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHH
ARQVAKYASGHTIVVEKSTVPVKTAELIKKILKSSNSSNKKKENSFSVLSSPEFLAEGSA
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHCCCH
INDLINPDRVLIGGDNEESIKKLCAIYENWIPKEKILVTNIWSSELSKLTANAFLAQRIS
HHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
SINSIAAICEKTGAEIKEVSAAIGSDTRIGNKFLLSSPGFGGSCFQKDILNLVYLSRYYG
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHC
LDHVAKYWENVISLNNWQKERISEVIVDKLFGTITGKKIVLLGFSFKANTNDTRESPSID
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHH
IAKNLLENGAKLVINDPRVSNKQIELALNQPSKEIDHNVEGIWYYEEDILEAVKSADAIV
HHHHHHHCCCEEEEECCCCCCCEEEEEECCCCHHHCCCCCEEEEEHHHHHHHHHCCCEEE
ILTEWQEYKNLNWELISKSMRKPSWVFDTRGIINRREIDVTPINLWTLGKG
EEECCHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]