Click here to switch to the map view.

The map label for this gene is ppiA [C]

Identifier: 126696685

GI number: 126696685

Start: 1124968

End: 1125573

Strand: Reverse

Name: ppiA [C]

Synonym: P9301_13471

Alternate gene names: 126696685

Gene position: 1125573-1124968 (Counterclockwise)

Preceding gene: 126696686

Following gene: 126696682

Centisome position: 68.55

GC content: 25.25

Gene sequence:

>606_bases
TTGTTTCAAGCTTGTAGTTATAAAAATAAGGTTGATTCAACTTATTATTGCCAAAAACTTAGATTTAGTTGTATTCAGAG
TAATAAAGTAGTTAATTTTAAAACTACAAAAGGTGATTTTGAGGTTGAATTATTTGGTAAAGATAACCCAGTAACAGTGT
CAAACTTTCTGGAAAACATAGACAATGATATTTACGTAAATCAAAAATTTTATAAAATAATAAATTTTACCCAAATAAGA
TTTGTACACGGCGGTGTTAATCCAAAAAATAAATTTTATTTTGAAGGAAATCAAAACCTGAAAAAGACAAGTCTATCAAT
ACCTTTAGAAATAAAATTTAAAGAAGAAAGTAAACCAAGATATAACTATCAAATAAAAAATCCTAACGAAATTGAAAATT
TAGTTAATACTTTTGAGAATGGTTCAATTGCTATGGTCAAGAGCTTTAACAATAAGTCTTCATCAACTGAATTTTTCTTT
GTAACAACTAATATCCCAGAATTAGATGGAAGATATTCAATTTTTGGAAAAATTATAAAAGGATTAGATGTACTCAAAAA
ACTTAATAAAGAAGACTACATCAAGGCAGTCCAGATAATTAATTAA

Upstream 100 bases:

>100_bases
AGGGGGCTCGTCTGGCTAAATTTTTGGATGTTAATTTGGAGGGCTTAAAATAAAAAAAAAATATTTATTAAGAATATTAT
TTTTTATACAGGTTCTGTTT

Downstream 100 bases:

>100_bases
ATTTCTAGTGAATATTTGTTTATTTTCAACATTTCTGTATTAACTCCTGAAGAGCGTTTAAGAGCAACCTTACCAGTCCT
CGCTATTTCAAGGATGCCGT

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: Peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase; Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin-Type; Peptidyl-Prolyl Cis-Trans Isomerase B; Peptidyl-Prolyl Cis-Trans Isomerase B Cyclophilin Type; Peptidyl-Prolyl Cis-Trans Isomerase A

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MFQACSYKNKVDSTYYCQKLRFSCIQSNKVVNFKTTKGDFEVELFGKDNPVTVSNFLENIDNDIYVNQKFYKIINFTQIR
FVHGGVNPKNKFYFEGNQNLKKTSLSIPLEIKFKEESKPRYNYQIKNPNEIENLVNTFENGSIAMVKSFNNKSSSTEFFF
VTTNIPELDGRYSIFGKIIKGLDVLKKLNKEDYIKAVQIIN

Sequences:

>Translated_201_residues
MFQACSYKNKVDSTYYCQKLRFSCIQSNKVVNFKTTKGDFEVELFGKDNPVTVSNFLENIDNDIYVNQKFYKIINFTQIR
FVHGGVNPKNKFYFEGNQNLKKTSLSIPLEIKFKEESKPRYNYQIKNPNEIENLVNTFENGSIAMVKSFNNKSSSTEFFF
VTTNIPELDGRYSIFGKIIKGLDVLKKLNKEDYIKAVQIIN
>Mature_201_residues
MFQACSYKNKVDSTYYCQKLRFSCIQSNKVVNFKTTKGDFEVELFGKDNPVTVSNFLENIDNDIYVNQKFYKIINFTQIR
FVHGGVNPKNKFYFEGNQNLKKTSLSIPLEIKFKEESKPRYNYQIKNPNEIENLVNTFENGSIAMVKSFNNKSSSTEFFF
VTTNIPELDGRYSIFGKIIKGLDVLKKLNKEDYIKAVQIIN

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 23409; Mature: 23409

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQACSYKNKVDSTYYCQKLRFSCIQSNKVVNFKTTKGDFEVELFGKDNPVTVSNFLENI
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCEEHHHHHHHC
DNDIYVNQKFYKIINFTQIRFVHGGVNPKNKFYFEGNQNLKKTSLSIPLEIKFKEESKPR
CCCEEECHHHHHHHCEEEEEEEECCCCCCCEEEECCCCCCEEEEEECEEEEEECCCCCCC
YNYQIKNPNEIENLVNTFENGSIAMVKSFNNKSSSTEFFFVTTNIPELDGRYSIFGKIIK
EEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
GLDVLKKLNKEDYIKAVQIIN
HHHHHHHCCHHHHHHEEEECC
>Mature Secondary Structure
MFQACSYKNKVDSTYYCQKLRFSCIQSNKVVNFKTTKGDFEVELFGKDNPVTVSNFLENI
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCEEHHHHHHHC
DNDIYVNQKFYKIINFTQIRFVHGGVNPKNKFYFEGNQNLKKTSLSIPLEIKFKEESKPR
CCCEEECHHHHHHHCEEEEEEEECCCCCCCEEEECCCCCCEEEEEECEEEEEECCCCCCC
YNYQIKNPNEIENLVNTFENGSIAMVKSFNNKSSSTEFFFVTTNIPELDGRYSIFGKIIK
EEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
GLDVLKKLNKEDYIKAVQIIN
HHHHHHHCCHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA