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The map label for this gene is ubiB [C]

Identifier: 126696528

GI number: 126696528

Start: 1002407

End: 1004062

Strand: Reverse

Name: ubiB [C]

Synonym: P9301_11901

Alternate gene names: 126696528

Gene position: 1004062-1002407 (Counterclockwise)

Preceding gene: 126696531

Following gene: 126696527

Centisome position: 61.15

GC content: 29.53

Gene sequence:

>1656_bases
ATGAAAAAATCTTATTCCAAATATTCAGCAAAAGATGATTTACTTTGGTTGATTTTGAGACCATGGATTTTTATACCAAG
AGTTTTATATATCCTTTTAACTTTTATTTTTCTTTTTTTGAGAATACTTTCTCAAGGTAACAGTAAAAATAAAAATGTAC
AAAAAAATCTCTCGAAATATCTTTTTGATGTAATAACAGACTTAGGTCCATGTTTTATCAAATTAGGTCAGGCACTCTCA
ACTAGGCCAGATCTTGTTAGACAAGATTGGCTTACAGAACTTACAAACTTACAAGATAATCTCCCAGCATTTGATCACAA
AATTGCTTTAAAAATTATTGAAGATGAACTTGGATCACCTGCTAATGAATTATTTCAAGAGTTTCCAGATAGTCCTATTG
CTTCTGCAAGTTTAGGTCAAGTTTATAAAGCAAAAATAAATGACTCTTATTTAGCTGTGAAAGTACAGAGGCCAAATTTA
TATTTTCTTATAAGAAGGGATATTGTAATTTTAAGGTTTTTAGGAACTTTTTTATCCCCAATTTTACCATTAAATATAGG
TGTTGGAATTGGGGAAATAATAGATGAGTTTGGTAAGGCACTTTTTGATGAAATTGACTATCAAAAAGAGGCCGAAAATG
CTTTGAAGTTTGCAAATTTATTCAAAGAAAACCCGAATATTTTTATTCCTAAATTAGAACAACAGTTTTCATCTAAAAGG
ATTATCACAACCTCTTGGATTGATGGAGTTAAGTTAAAAGATCGAGCCTTATTGGAGGAAAATAACTTAATACCTGCTTC
ATTTATAAAAACTTGTGTTATCAGTGGTCTCCAGCAATTATTTGAATTTGGATATTTTCATGCAGACCCACATCCAGGAA
ATATGTTTGCTCTTAAAGGAGGAAATGCAGATTGTGGAAATTTGGCTTATGTTGATTTCGGAATGATGGATAATATTTCT
AATTCAGATAGACTTACTCTTATTAAAGCAATTGTTCACATAATAAACGAAGAATATTTTCTTTTGGCAGAAGATTTCCA
GAAATTAGGTTTCTTAACCAAAGAACAAGATCTTAACCAACTTGTAGAACCATTAAAAGAAGTTCTTGGTGGATCCCTAA
GCGCTGAGGTTGGTAATTTTAATCTTAAAAATGTAACTGATAAATTTTCAAAACTTATGTATTCCTATCCTTTCAGGGTT
CCCAGTAGGTTTGCCTTAATAATAAGAGCCGTTGTTAGTCAAGAAGGTTTAGCACTAAGACTAGATCCTGAATTTAAAAT
TTTAAAAATAGCTTATCCATATATTGCTAAAAAACTACTTACCGATAATTCTGAGGAGATTTTAGAAATCCTTTTAGAAG
TCGTTTTTGATAAAAAAGGTCAAATTCAAATAGAAAAAGTTGAAAGTTTATTAAATATTTTATTTAAAGATTCAGAAAAT
ATTAATTCAGATCTTATACCAGTAGCTAACGCTGGATTGAAATTATTTGTCAGTAAGAAAGGATCCGAAGTTCGAAAGAA
TCTTCTTTTAAGCCTTATAAAAGATGAAAAATTAGAATTTACTGATGCTAAAAAACTCTTCAGTTTAATTAGAGATACTT
TTAGCCCTTTAAATATTGCAAAAAGTGCAGTTCAAAATTTTATTTCTACAGTTTAG

Upstream 100 bases:

>100_bases
TAAAAACTTTTTAGTTAGAAAAGATGAAATGCTCATAAAGTATTATCTACATATATAGAATGAATTACGTGGTAATCTTT
TTTGATATTTTTTAACTTTG

Downstream 100 bases:

>100_bases
TTTTTATATTTATATGCAATGAATTTACTTATGATTTTAATTAGATTAGAATCAATAGAGAATGTGGTTTTTAAAAAAAA
TTGAGTAGAAAAAGGATTAA

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MKKSYSKYSAKDDLLWLILRPWIFIPRVLYILLTFIFLFLRILSQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKIALKIIEDELGSPANELFQEFPDSPIASASLGQVYKAKINDSYLAVKVQRPNL
YFLIRRDIVILRFLGTFLSPILPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEQQFSSKR
IITTSWIDGVKLKDRALLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADCGNLAYVDFGMMDNIS
NSDRLTLIKAIVHIINEEYFLLAEDFQKLGFLTKEQDLNQLVEPLKEVLGGSLSAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGQIQIEKVESLLNILFKDSEN
INSDLIPVANAGLKLFVSKKGSEVRKNLLLSLIKDEKLEFTDAKKLFSLIRDTFSPLNIAKSAVQNFISTV

Sequences:

>Translated_551_residues
MKKSYSKYSAKDDLLWLILRPWIFIPRVLYILLTFIFLFLRILSQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKIALKIIEDELGSPANELFQEFPDSPIASASLGQVYKAKINDSYLAVKVQRPNL
YFLIRRDIVILRFLGTFLSPILPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEQQFSSKR
IITTSWIDGVKLKDRALLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADCGNLAYVDFGMMDNIS
NSDRLTLIKAIVHIINEEYFLLAEDFQKLGFLTKEQDLNQLVEPLKEVLGGSLSAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGQIQIEKVESLLNILFKDSEN
INSDLIPVANAGLKLFVSKKGSEVRKNLLLSLIKDEKLEFTDAKKLFSLIRDTFSPLNIAKSAVQNFISTV
>Mature_551_residues
MKKSYSKYSAKDDLLWLILRPWIFIPRVLYILLTFIFLFLRILSQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKIALKIIEDELGSPANELFQEFPDSPIASASLGQVYKAKINDSYLAVKVQRPNL
YFLIRRDIVILRFLGTFLSPILPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEQQFSSKR
IITTSWIDGVKLKDRALLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADCGNLAYVDFGMMDNIS
NSDRLTLIKAIVHIINEEYFLLAEDFQKLGFLTKEQDLNQLVEPLKEVLGGSLSAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGQIQIEKVESLLNILFKDSEN
INSDLIPVANAGLKLFVSKKGSEVRKNLLLSLIKDEKLEFTDAKKLFSLIRDTFSPLNIAKSAVQNFISTV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=280, Percent_Identity=26.7857142857143, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI41393593, Length=330, Percent_Identity=26.969696969697, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI217035081, Length=279, Percent_Identity=25.4480286738351, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI34147522, Length=254, Percent_Identity=27.9527559055118, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI27363457, Length=212, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217416386, Length=212, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=440, Percent_Identity=26.3636363636364, Blast_Score=156, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=276, Percent_Identity=30.0724637681159, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=288, Percent_Identity=28.125, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=271, Percent_Identity=29.520295202952, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=246, Percent_Identity=28.0487804878049, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325148, Length=248, Percent_Identity=26.2096774193548, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24662575, Length=283, Percent_Identity=26.5017667844523, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI22024280, Length=306, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI18859849, Length=269, Percent_Identity=25.6505576208178, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62603; Mature: 62603

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSYSKYSAKDDLLWLILRPWIFIPRVLYILLTFIFLFLRILSQGNSKNKNVQKNLSKY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPAFDHKIALKIIEDELGSP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
ANELFQEFPDSPIASASLGQVYKAKINDSYLAVKVQRPNLYFLIRRDIVILRFLGTFLSP
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHH
ILPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEQQFSSKR
HHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCC
IITTSWIDGVKLKDRALLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKG
EEEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
GNADCGNLAYVDFGMMDNISNSDRLTLIKAIVHIINEEYFLLAEDFQKLGFLTKEQDLNQ
CCCCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHH
LVEPLKEVLGGSLSAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLALR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
LDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGQIQIEKVESLLNILFKDSEN
ECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
INSDLIPVANAGLKLFVSKKGSEVRKNLLLSLIKDEKLEFTDAKKLFSLIRDTFSPLNIA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
KSAVQNFISTV
HHHHHHHHHCC
>Mature Secondary Structure
MKKSYSKYSAKDDLLWLILRPWIFIPRVLYILLTFIFLFLRILSQGNSKNKNVQKNLSKY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPAFDHKIALKIIEDELGSP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
ANELFQEFPDSPIASASLGQVYKAKINDSYLAVKVQRPNLYFLIRRDIVILRFLGTFLSP
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHH
ILPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEQQFSSKR
HHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCC
IITTSWIDGVKLKDRALLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKG
EEEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
GNADCGNLAYVDFGMMDNISNSDRLTLIKAIVHIINEEYFLLAEDFQKLGFLTKEQDLNQ
CCCCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHH
LVEPLKEVLGGSLSAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLALR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
LDPEFKILKIAYPYIAKKLLTDNSEEILEILLEVVFDKKGQIQIEKVESLLNILFKDSEN
ECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
INSDLIPVANAGLKLFVSKKGSEVRKNLLLSLIKDEKLEFTDAKKLFSLIRDTFSPLNIA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
KSAVQNFISTV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]