Click here to switch to the map view.

The map label for this gene is thrA [H]

Identifier: 126696495

GI number: 126696495

Start: 970319

End: 971620

Strand: Reverse

Name: thrA [H]

Synonym: P9301_11571

Alternate gene names: 126696495

Gene position: 971620-970319 (Counterclockwise)

Preceding gene: 126696496

Following gene: 126696494

Centisome position: 59.18

GC content: 32.1

Gene sequence:

>1302_bases
ATGAGAAAATGCAAAATTGGGATTGTAGGTTTTGGAACTGTAGGTTCAGGGATTTATAAAATATTAAGTTCTGAAGTTGA
TTCACATCCAATTCTAAAAGAAATAGAAATTGCAAAAATAGCAGTTAAAGATCTTAATAAAAAAAGGGATATTGAGCTAG
ATAATAATTTATTAACTGATGATCCATTTAAATTAATTAATGACCCCTCTATTGATGTAATTGTTGAAGTAATGGGTGGG
GTTGATTTAGCTAAAGATATTATTCTGCAATCTTTAAAATTAGGTAAATCTGTTGTTACAGCAAATAAAGCAGTTATCGC
AAGATATGGAGAAGAAATATATAAAACTGCATCTAAAGAAAGAGTTTATATATTGTCAGAGGCAGCAGTTTGCGGAGGGA
TTCCTATCATTGAACCCTTAAAAAGATCATTAAAAAGTAACTGTATAAAAAGAATGGTTGGGATAATAAATGGCACAACA
AATTTTATTCTTTCAAAGATGACAAATGAAAAAGCTGATTACAAGGAGACCTTAAAATTGGCTCAAAGCCTTGGATATGC
AGAATTTGATCCAACTGCAGATGTTGAGGGCCATGATGCTGCTGATAAGATTTCAATTCTTAGTGAACTTGCATTCGGAG
GGAAAATCAAAAGAGAGGAGATTCATTTTGAGGGCATTAGTAAAATTAATCTAAAGGATATTGAATATGCCAATAAATTA
GGGTTTGAAATAAAACTTTTAGCGCTATCCGAAAGGGGACAAATTAATAGTAATGATTCACTCGCTTTAAATATTTGGGT
AGGACCTTCTTTGATTCCAAAATCTCATCCATTGTCAACAGTTAAGGGAGTTAATAATGCCTTATTGATTGAAGCTGATC
CTCTTGGTGAAATAATGTTATATGGTCCAGGTGCAGGGAGTGGCCCAACTGCAGCGTCAGTGGTATCAGATATATTAAAT
CTGCATGCCGCCAAAGAAAAAAATAATAATTCAGTCGATCCATTATTATCTTTTGATTTCTGGAGAAACTGCCATATAAC
AAGCTCCTCACAAATAAATAAAAAAAATTACCTTAGAATTATTTGTCTTGATAGTCCAGGTGTCATAGGAAAGATTGGAG
ATATTTTTGGAAAGAATAATGTATCAATTGAATCAATTGTTCAACTTGATGCTAGTGAGGACAAAGCTGAAATTGTCGTT
ATTACTCATGAGGTGAATAATGGAGATTTTGAGAGATCGAAAGATGAAATAAATTCGCTAAATGAAGTCAAAATTATTGC
AAGTCAATTAAGTTGTATTTAA

Upstream 100 bases:

>100_bases
TGGTTTTTTAAACATTTTATTGAAAATGCAGTCTCAAGCAAATGAATTTTTGTAGGCCTAATAATATAAAATTAAACTCA
AAGTTAAAAAGAAATAAAAA

Downstream 100 bases:

>100_bases
AAAAATAGTTTGCAAATTTCTTTATAGCTTGGTAAACCGAAGAAAGTAAGTGTTTGGTTTTAGCACCTTAATGATTCATT
CAAAACTATTAGATAATAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRKCKIGIVGFGTVGSGIYKILSSEVDSHPILKEIEIAKIAVKDLNKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKLGKSVVTANKAVIARYGEEIYKTASKERVYILSEAAVCGGIPIIEPLKRSLKSNCIKRMVGIINGTT
NFILSKMTNEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHFEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAAKEKNNNSVDPLLSFDFWRNCHITSSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKDEINSLNEVKIIASQLSCI

Sequences:

>Translated_433_residues
MRKCKIGIVGFGTVGSGIYKILSSEVDSHPILKEIEIAKIAVKDLNKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKLGKSVVTANKAVIARYGEEIYKTASKERVYILSEAAVCGGIPIIEPLKRSLKSNCIKRMVGIINGTT
NFILSKMTNEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHFEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAAKEKNNNSVDPLLSFDFWRNCHITSSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKDEINSLNEVKIIASQLSCI
>Mature_433_residues
MRKCKIGIVGFGTVGSGIYKILSSEVDSHPILKEIEIAKIAVKDLNKKRDIELDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKLGKSVVTANKAVIARYGEEIYKTASKERVYILSEAAVCGGIPIIEPLKRSLKSNCIKRMVGIINGTT
NFILSKMTNEKADYKETLKLAQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHFEGISKINLKDIEYANKL
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHAAKEKNNNSVDPLLSFDFWRNCHITSSSQINKKNYLRIICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVV
ITHEVNNGDFERSKDEINSLNEVKIIASQLSCI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=27.710843373494, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47142; Mature: 47142

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKCKIGIVGFGTVGSGIYKILSSEVDSHPILKEIEIAKIAVKDLNKKRDIELDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKDIILQSLKLGKSVVTANKAVIARYGEEIYKTASKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCC
RVYILSEAAVCGGIPIIEPLKRSLKSNCIKRMVGIINGTTNFILSKMTNEKADYKETLKL
EEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
AQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHFEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHC
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHAAKEKNNNSVDPLLSFDFWRNCHITSSSQINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCEEECCCCCCCCCCCEEE
ICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVVITHEVNNGDFERSKDEINSL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHCCH
NEVKIIASQLSCI
HHHHHHHHHHCCC
>Mature Secondary Structure
MRKCKIGIVGFGTVGSGIYKILSSEVDSHPILKEIEIAKIAVKDLNKKRDIELDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKDIILQSLKLGKSVVTANKAVIARYGEEIYKTASKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCC
RVYILSEAAVCGGIPIIEPLKRSLKSNCIKRMVGIINGTTNFILSKMTNEKADYKETLKL
EEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
AQSLGYAEFDPTADVEGHDAADKISILSELAFGGKIKREEIHFEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHC
GFEIKLLALSERGQINSNDSLALNIWVGPSLIPKSHPLSTVKGVNNALLIEADPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHAAKEKNNNSVDPLLSFDFWRNCHITSSSQINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCEEECCCCCCCCCCCEEE
ICLDSPGVIGKIGDIFGKNNVSIESIVQLDASEDKAEIVVITHEVNNGDFERSKDEINSL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHCCH
NEVKIIASQLSCI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]