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The map label for this gene is folP [H]

Identifier: 126696378

GI number: 126696378

Start: 901060

End: 901905

Strand: Reverse

Name: folP [H]

Synonym: P9301_10401

Alternate gene names: 126696378

Gene position: 901905-901060 (Counterclockwise)

Preceding gene: 126696379

Following gene: 126696376

Centisome position: 54.93

GC content: 31.68

Gene sequence:

>846_bases
TTGCAAATTATCAATAAGAAAAATAAATGGCCAAAAGGCTGGGGCCAAAAAACTTCAATTATGGGAGTTATAAATTTAAC
TCCTGATTCATTTAGTGATGGTGGGGAAATAAACTCTTCAAAAAAAGTTTTAGATCAAGTAAATCATTTCATGAGCAATG
GTGTTGATGTTATTGATCTTGGTGCCCAAAGTACGAGACCTGGGGCTGAAGAAGTTGGATCAAGTATAGAGATAAAAAGA
TTGATCCCATACCTAAAATTAATAAAATCCGAATTTCCAGATGTTTTAATTTCTGTTGATACTTTTAATTCTGAAGTTGC
TTACGAAGCTCTTTTAAATGGTGCTAATTGGATAAATGATGTCACGGGAGGAAGAAGAGATGTAAAAATTTTGGATGTTG
TATCAAAATTCAACTGTCCATTCGTCATAACTCATAGTCGTGGTAATAGTCAAAATATGAATCAACTCTCCAATTACGAG
AATGTTTTGAGTGATGTCAAGTGTTCGCTTGATAATTTAATAAAGAATGCTTTAGAAAAAAATATATCTGAAGGAAATAT
AATAGTGGATCCTGGAATTGGTTTTTCAAAAGATATCATTCATAATTTGGAAATCTTGAGAAACTTAGATGTATTTAAAA
AATGGAATTTGCCAATTTTGGTAGGTGCATCTAGGAAGAGATTTCTAGGGGAAATATTGAATGAGAAAAATCCAAAAGAA
AGGGATATTGGAACACTTGCAATAAGTTGTCTTTGTTCTCAATTTAATATTGACATTGTGAGAGTCCACAACGTCAAATT
AAATTATCAAATACTGAGAGTAGCGGATAGGATTTACAGAAAATAG

Upstream 100 bases:

>100_bases
TCTGTTAAGCCTAATAATATCGACGAAATCATGTCAATGAGTGATATCGATGGGGTGCTAGTCGGAGGGGCTTCATTAGA
TCCGAATAGTTTCGCGAGAA

Downstream 100 bases:

>100_bases
TAAATTTATTATTCTTTAACTCCTTCGATTTTATCCTCTACCTCTTGGTATAGTTCTTTCAATTGTTCTATATTCTCATC
TGAAGTTTCCCAATATCCCC

Product: putative dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQIINKKNKWPKGWGQKTSIMGVINLTPDSFSDGGEINSSKKVLDQVNHFMSNGVDVIDLGAQSTRPGAEEVGSSIEIKR
LIPYLKLIKSEFPDVLISVDTFNSEVAYEALLNGANWINDVTGGRRDVKILDVVSKFNCPFVITHSRGNSQNMNQLSNYE
NVLSDVKCSLDNLIKNALEKNISEGNIIVDPGIGFSKDIIHNLEILRNLDVFKKWNLPILVGASRKRFLGEILNEKNPKE
RDIGTLAISCLCSQFNIDIVRVHNVKLNYQILRVADRIYRK

Sequences:

>Translated_281_residues
MQIINKKNKWPKGWGQKTSIMGVINLTPDSFSDGGEINSSKKVLDQVNHFMSNGVDVIDLGAQSTRPGAEEVGSSIEIKR
LIPYLKLIKSEFPDVLISVDTFNSEVAYEALLNGANWINDVTGGRRDVKILDVVSKFNCPFVITHSRGNSQNMNQLSNYE
NVLSDVKCSLDNLIKNALEKNISEGNIIVDPGIGFSKDIIHNLEILRNLDVFKKWNLPILVGASRKRFLGEILNEKNPKE
RDIGTLAISCLCSQFNIDIVRVHNVKLNYQILRVADRIYRK
>Mature_281_residues
MQIINKKNKWPKGWGQKTSIMGVINLTPDSFSDGGEINSSKKVLDQVNHFMSNGVDVIDLGAQSTRPGAEEVGSSIEIKR
LIPYLKLIKSEFPDVLISVDTFNSEVAYEALLNGANWINDVTGGRRDVKILDVVSKFNCPFVITHSRGNSQNMNQLSNYE
NVLSDVKCSLDNLIKNALEKNISEGNIIVDPGIGFSKDIIHNLEILRNLDVFKKWNLPILVGASRKRFLGEILNEKNPKE
RDIGTLAISCLCSQFNIDIVRVHNVKLNYQILRVADRIYRK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=257, Percent_Identity=36.9649805447471, Blast_Score=178, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=33.0218068535826, Blast_Score=162, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31540; Mature: 31540

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIINKKNKWPKGWGQKTSIMGVINLTPDSFSDGGEINSSKKVLDQVNHFMSNGVDVIDL
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEFPDVLISVDTFNSEVAYEALLNGANWIND
CCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHH
VTGGRRDVKILDVVSKFNCPFVITHSRGNSQNMNQLSNYENVLSDVKCSLDNLIKNALEK
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NISEGNIIVDPGIGFSKDIIHNLEILRNLDVFKKWNLPILVGASRKRFLGEILNEKNPKE
CCCCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCHHHHHHHHHCCCCCCH
RDIGTLAISCLCSQFNIDIVRVHNVKLNYQILRVADRIYRK
HHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCC
>Mature Secondary Structure
MQIINKKNKWPKGWGQKTSIMGVINLTPDSFSDGGEINSSKKVLDQVNHFMSNGVDVIDL
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GAQSTRPGAEEVGSSIEIKRLIPYLKLIKSEFPDVLISVDTFNSEVAYEALLNGANWIND
CCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHH
VTGGRRDVKILDVVSKFNCPFVITHSRGNSQNMNQLSNYENVLSDVKCSLDNLIKNALEK
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NISEGNIIVDPGIGFSKDIIHNLEILRNLDVFKKWNLPILVGASRKRFLGEILNEKNPKE
CCCCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEECCCHHHHHHHHHCCCCCCH
RDIGTLAISCLCSQFNIDIVRVHNVKLNYQILRVADRIYRK
HHHHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]