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The map label for this gene is prlC [H]

Identifier: 126695957

GI number: 126695957

Start: 544900

End: 546987

Strand: Reverse

Name: prlC [H]

Synonym: P9301_06191

Alternate gene names: 126695957

Gene position: 546987-544900 (Counterclockwise)

Preceding gene: 126695958

Following gene: 126695952

Centisome position: 33.31

GC content: 32.66

Gene sequence:

>2088_bases
ATGGATACCTCGATTTTTAAATATGGAGAATTACCAGAATTTAAAAAATTTACTCCCGAAATCATAAGTATACAATTCCC
AGAAGTACTAAAAAAGATAGCTGAAGATTTTGAAAACATTGAGAAAAATTTATCTAACTATTTGATTAACAATGATTTAA
GTTGGGAAAATGTAATAAATCCCTTAAATGAAGTCAATGAAATCCTTAGATGGAGTTGGGGAGTAATAAGCCACCTAAAT
GCAGTAAATAATTCTGAAAGTCTGAGAGAAATTTATTCAAAATTTCTTCCAGAGATTATAAGCTTTAGTAATAAATTCGG
ACAAAGTAAAATAATTTACAATTCTTTAGTCAAGCTTAAAGAGACTAATAACTTTGATCAAATTAAAAACAGAATTTTAG
ATAAAGAAATTCTTGAGATGCAACATAGAGGCATTTCACTGCAAAAGAATGATCAAGAAGAATTCAACAAAATTTCAGAA
AAGCTTGGAAAACTATCAACAGACTTCAGCAATAATGTTCTCGATGCGACTAATAAATGGTTTTTAATATTAAATAAAAA
ATCTGAAGTTGATGGTCTTCCGGAACGCGTACTTGAATTAATGGCATTTTCTGCACACAACCACTTAAAAAAAGATGAAG
AAGTCGATATCAAAAATGGTCCTTGGAAATTAAGTCTAGATATCCCAACTTATACTTCATACATGACATATGCCACCGAC
CGTAACCTTAGAGAGAAACTATATAAGGCATTCGTTAGTAGGGCATCTCAAGGAGAAAAAAATAATTCTCCAATCATTGA
AGAGATATTATCTCTTAGAACTAAACAAGCTAATCTTCTCGGTTATAAAAGTTGGGCAGAACTAAGTTTGTCAACGAAAA
TGGCGAAAGAAATTAAAAATGTTGAAAACCTTTTAGAAGAATTGAGAGAACCAGCATTCAAAACCGCAAAAATTGAATTA
GAAACCCTTAATAAGTTTTCTAAAGCTAATGGGTTTTCAGAATCACAGAATATCGAGCCATGGGATATTAGTTATTGGTC
AGAACTTCTTAGAAAGGAAAAGCTCAATTTGGATCAAGAGTCCTTGAGACCTTGGTTCCCACTAAATGATGTTTTGAAAG
GTTTATTTAAATTAAGTGAAAAGCTTTTTGAAATTCAAGTTGTCGAGGCAACTGATGAGGCGCCTCTTTGGAATGATGAC
GTTTTATTTTTTAATATCCTCAATAAAGAAGATAAGAAAATAGCATCTTTTTACCTGGATCCATACTCTAGGCCGGAATC
AAAGAGAGGAGGGGCTTGGATGGATGAATGTTTGAATAAAAACAATATTGGTAAAAAGACCCTTCCTGTAGCTTATCTCG
TTTGTAATCAGACTCCACCATCAAAAGATAAACCGAGTTTGATGAGTTTTGAAGAAGTTCAGACTTTGTTCCATGAATTT
GGTCATGGTCTTCAACACATGCTTACCACTGTAAATCTTCCTCAAGCAGCTGGTATTAATAATGTTGAATGGGATGCAGT
CGAACTTCCAAGTCAATTCATGGAAAACTGGTGTTTCCACAAAAACACACTGTTGAATATTGCTAAGCACTATAAAACAG
GAGAAAAATTATCCGATGAAAATTTTGAGAAGCTCCTAAAGAATAGAACTTTCAATTGTGGAATGGCGACTCTTAGACAA
CTACATTTTGCAATAACAGACCTCAGATTACACAGTAGTATTGATAAAAACGAAGGTAAAACAGCAGATGAAATAAGAAG
AGAAATTTCGAAACAAACTACTGTTATTGAACCAATTCAAGAAGATCAATTTCTTTGTTGTTTTAGTCATATATTTGCAG
GAGGATATTCTGCAGGATATTACTCATATAAATGGGCTGAAGTTCTAAGTGCTGATGCATTTTCAATGTTTGAAGAGGCT
GATTTAGAAAACTCTGAAGATTTAAAATTAATAGGAAAGAAATTTAAAGATACGATACTTAGTCTGGGTGGAAGCTTACC
TCCATTGGATATATTTAAATTATTTAGGGGAAGAGAGCCACAAACAGATTCTTTAATAAGACACTTGGGTCTATCTGGAG
CTACATAA

Upstream 100 bases:

>100_bases
AATTTATACGAATCTTCAACGAATGCTCTCAGTCAGCAGCTCACTTTAGCTAAGTTGGTTGGATTAATACCAACTTTAGT
TAATTAGATTACTTAAATAA

Downstream 100 bases:

>100_bases
TAATTTCATCGATTATTTTGTCAACGACTGATTTGTTTCTTACCAGATTTCTATGTTTATAAACTTTTACTGATATTTTT
TTCCCAAATTTTAAATTTGT

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MDTSIFKYGELPEFKKFTPEIISIQFPEVLKKIAEDFENIEKNLSNYLINNDLSWENVINPLNEVNEILRWSWGVISHLN
AVNNSESLREIYSKFLPEIISFSNKFGQSKIIYNSLVKLKETNNFDQIKNRILDKEILEMQHRGISLQKNDQEEFNKISE
KLGKLSTDFSNNVLDATNKWFLILNKKSEVDGLPERVLELMAFSAHNHLKKDEEVDIKNGPWKLSLDIPTYTSYMTYATD
RNLREKLYKAFVSRASQGEKNNSPIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKTAKIEL
ETLNKFSKANGFSESQNIEPWDISYWSELLRKEKLNLDQESLRPWFPLNDVLKGLFKLSEKLFEIQVVEATDEAPLWNDD
VLFFNILNKEDKKIASFYLDPYSRPESKRGGAWMDECLNKNNIGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREISKQTTVIEPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT

Sequences:

>Translated_695_residues
MDTSIFKYGELPEFKKFTPEIISIQFPEVLKKIAEDFENIEKNLSNYLINNDLSWENVINPLNEVNEILRWSWGVISHLN
AVNNSESLREIYSKFLPEIISFSNKFGQSKIIYNSLVKLKETNNFDQIKNRILDKEILEMQHRGISLQKNDQEEFNKISE
KLGKLSTDFSNNVLDATNKWFLILNKKSEVDGLPERVLELMAFSAHNHLKKDEEVDIKNGPWKLSLDIPTYTSYMTYATD
RNLREKLYKAFVSRASQGEKNNSPIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKTAKIEL
ETLNKFSKANGFSESQNIEPWDISYWSELLRKEKLNLDQESLRPWFPLNDVLKGLFKLSEKLFEIQVVEATDEAPLWNDD
VLFFNILNKEDKKIASFYLDPYSRPESKRGGAWMDECLNKNNIGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREISKQTTVIEPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
>Mature_695_residues
MDTSIFKYGELPEFKKFTPEIISIQFPEVLKKIAEDFENIEKNLSNYLINNDLSWENVINPLNEVNEILRWSWGVISHLN
AVNNSESLREIYSKFLPEIISFSNKFGQSKIIYNSLVKLKETNNFDQIKNRILDKEILEMQHRGISLQKNDQEEFNKISE
KLGKLSTDFSNNVLDATNKWFLILNKKSEVDGLPERVLELMAFSAHNHLKKDEEVDIKNGPWKLSLDIPTYTSYMTYATD
RNLREKLYKAFVSRASQGEKNNSPIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKTAKIEL
ETLNKFSKANGFSESQNIEPWDISYWSELLRKEKLNLDQESLRPWFPLNDVLKGLFKLSEKLFEIQVVEATDEAPLWNDD
VLFFNILNKEDKKIASFYLDPYSRPESKRGGAWMDECLNKNNIGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREISKQTTVIEPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=653, Percent_Identity=28.4839203675345, Blast_Score=257, Evalue=3e-68,
Organism=Homo sapiens, GI14149738, Length=687, Percent_Identity=28.0931586608443, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI156105687, Length=624, Percent_Identity=23.3974358974359, Blast_Score=139, Evalue=9e-33,
Organism=Escherichia coli, GI1789913, Length=695, Percent_Identity=40.7194244604317, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1787819, Length=645, Percent_Identity=29.1472868217054, Blast_Score=251, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71999758, Length=582, Percent_Identity=22.8522336769759, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565901, Length=595, Percent_Identity=21.5126050420168, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=576, Percent_Identity=29.8611111111111, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322715, Length=501, Percent_Identity=26.3473053892216, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356111, Length=704, Percent_Identity=28.6931818181818, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI20129717, Length=469, Percent_Identity=23.2409381663113, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80213; Mature: 80213

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSIFKYGELPEFKKFTPEIISIQFPEVLKKIAEDFENIEKNLSNYLINNDLSWENVIN
CCCCCCCCCCCCCHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
PLNEVNEILRWSWGVISHLNAVNNSESLREIYSKFLPEIISFSNKFGQSKIIYNSLVKLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDQIKNRILDKEILEMQHRGISLQKNDQEEFNKISEKLGKLSTDFSNNVLDATNKW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
FLILNKKSEVDGLPERVLELMAFSAHNHLKKDEEVDIKNGPWKLSLDIPTYTSYMTYATD
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHC
RNLREKLYKAFVSRASQGEKNNSPIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VENLLEELREPAFKTAKIELETLNKFSKANGFSESQNIEPWDISYWSELLRKEKLNLDQE
HHHHHHHHHCCHHHHHHEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFKLSEKLFEIQVVEATDEAPLWNDDVLFFNILNKEDKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCC
PYSRPESKRGGAWMDECLNKNNIGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYKTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHH
NFEKLLKNRTFNCGMATLRQLHFAITDLRLHSSIDKNEGKTADEIRREISKQTTVIEPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
EDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENSEDLKLIGKKFKDTIL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MDTSIFKYGELPEFKKFTPEIISIQFPEVLKKIAEDFENIEKNLSNYLINNDLSWENVIN
CCCCCCCCCCCCCHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
PLNEVNEILRWSWGVISHLNAVNNSESLREIYSKFLPEIISFSNKFGQSKIIYNSLVKLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDQIKNRILDKEILEMQHRGISLQKNDQEEFNKISEKLGKLSTDFSNNVLDATNKW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
FLILNKKSEVDGLPERVLELMAFSAHNHLKKDEEVDIKNGPWKLSLDIPTYTSYMTYATD
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHC
RNLREKLYKAFVSRASQGEKNNSPIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VENLLEELREPAFKTAKIELETLNKFSKANGFSESQNIEPWDISYWSELLRKEKLNLDQE
HHHHHHHHHCCHHHHHHEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFKLSEKLFEIQVVEATDEAPLWNDDVLFFNILNKEDKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHCC
PYSRPESKRGGAWMDECLNKNNIGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYKTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHH
NFEKLLKNRTFNCGMATLRQLHFAITDLRLHSSIDKNEGKTADEIRREISKQTTVIEPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
EDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENSEDLKLIGKKFKDTIL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]