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The map label for this gene is ndhD1 [H]

Identifier: 126695958

GI number: 126695958

Start: 547001

End: 548542

Strand: Reverse

Name: ndhD1 [H]

Synonym: P9301_06201

Alternate gene names: 126695958

Gene position: 548542-547001 (Counterclockwise)

Preceding gene: 126695959

Following gene: 126695957

Centisome position: 33.41

GC content: 35.6

Gene sequence:

>1542_bases
ATGAATTTAGAATCTTTTCCCTGGCTATCATCTGTTGTTTTACTGCCTTTAATTGGGGCAATAATAATGCCTTTCTTGAG
TTCGAAAGAAGGAGAAGATAATACACTCCCTAGAAATATCTCATTAAGTTTTTTATTTATAGATTTTTTATTAATAATTG
GCGTCCTTTTTCAAAAATTCAATACTTCAGATAGCTCCTTACAACTTGTAGAGAGAGCTTCTTGGTTGCCCTCAATAGGT
TTAGAGTGGTCTCTTGGCGTAGATGGGTTATCTGCTCCTCTAGTAGCTTTGAGTGGGTTAATTACATTTTTATCAGCTGC
GGCAAGTTGGAAAATTAAGAAAAAATCTAATCTATACTTTGCTCTTTTATTAGTGCAAGCCTCAGCACAAGCATTAGTTT
TCCTCTCTCAAGACTTCCTATTATTTTTCTTAGCATGGGAACTTGAGTTGGTTCCGGTATATCTTCTTATTGCTATTTGG
GGAGGGAAAAAGAAATTATATGCAGCCACAAAATTTATTCTTTATACAGCTTTAGCTTCTTTATTAATACTCATAAGTGG
TTTAGCACTTGCTTTGAGTGGTGATACTTTTACTTTAAATATTACCGATATAACCAATAAACATGTAACGGGCAGCCTAG
CTTTATTATCATATTTAGGATTTTTAATTGGTTTTGGAGTAAAACTTCCTATCTTTCCATTACATACTTGGTTACCCGAT
GCACATGGTGAGGCTAATGCTCCAGTTTCAATGTTACTAGCTGGAATACTTTTAAAAATGGGAGGTTATGCCCTCTTAAG
ATTCAATGTTCAAATACTACCTGAAGTACATCTTCAAATTGCACCTGCGCTTATTATTCTTGGAATCATTAATATAATTT
ATGGAGCTCTTAATGCATTTGCTCAAGATAATGTTAAAAGGAGAATTGCTTGTAGCTCTGTTAGTCATATGGGTTTTGTT
CTATTAGGGATTGGAGCAGTAGATGCTTTAGGTATAAGCGGAGCAATGCTCCAAATGATTAGTCACGGACTTATAGCTGC
AGCTATGTTTTTTGTTACGGGCTCATTCTATGAAAGAACAAATACTCTTTCGATACCAAATATGGGCGGTTTGGCAAAGG
TTTTGCCAATAACATTTGCTTTTTTCTTGGCAAGTTCTTTGGCCTCTCTAGCCCTTCCTGGGATGAGCGGATTTATAAGT
GAAATAACCGTATTTTTAGGAATCACTAGCCAAGAAGGCTTCAGTTCTATATTTAGATCGATCACTATTCTTATTGCAGC
CATAGGTTTAGTTCTAACGCCAATATACCTACTATCAATGTGTAGAAGAGTATTCTTTGGACCTAGAATTCCTGCGTTAG
CTACAGTTAAAGAGATGAATGGTAGAGAATTGACGATTGGGTTCAGCTTATTATTGCCTACTTTGGTTATAGGTTTTTGG
CCAAAAATCGCGATAAATTTATACGAATCTTCAACGAATGCTCTCAGTCAGCAGCTCACTTTAGCTAAGTTGGTTGGATT
AATACCAACTTTAGTTAATTAG

Upstream 100 bases:

>100_bases
AGCACTATCTCTGGTAAGTAGTTTTACTTAGGCATTTTTAATGTTATAGTCTCAAGCTAGTACAACTTCAACTAGAATAA
AAAAATTATTCATTCCATAA

Downstream 100 bases:

>100_bases
ATTACTTAAATAAATGGATACCTCGATTTTTAAATATGGAGAATTACCAGAATTTAAAAAATTTACTCCCGAAATCATAA
GTATACAATTCCCAGAAGTA

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MNLESFPWLSSVVLLPLIGAIIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFNTSDSSLQLVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDITNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLVGLIPTLVN

Sequences:

>Translated_513_residues
MNLESFPWLSSVVLLPLIGAIIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFNTSDSSLQLVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDITNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLVGLIPTLVN
>Mature_513_residues
MNLESFPWLSSVVLLPLIGAIIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFNTSDSSLQLVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDITNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLVGLIPTLVN

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=375, Percent_Identity=31.4666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI251831117, Length=358, Percent_Identity=27.0949720670391, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=512, Percent_Identity=36.71875, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1788831, Length=346, Percent_Identity=27.1676300578035, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788827, Length=288, Percent_Identity=28.4722222222222, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788829, Length=299, Percent_Identity=27.4247491638796, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788614, Length=465, Percent_Identity=26.4516129032258, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=195, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=313, Percent_Identity=27.1565495207668, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 55305; Mature: 55305

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLESFPWLSSVVLLPLIGAIIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
NTSDSSLQLVERASWLPSIGLEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYF
CCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEE
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKKLYAATKFILYTALAS
EEHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNITDITNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSIFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTNALSQQLTLAKLVGLIPTLVN
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLESFPWLSSVVLLPLIGAIIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
NTSDSSLQLVERASWLPSIGLEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYF
CCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEE
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKKLYAATKFILYTALAS
EEHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNITDITNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSIFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTNALSQQLTLAKLVGLIPTLVN
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA