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The map label for this gene is hemE

Identifier: 126695947

GI number: 126695947

Start: 532301

End: 533341

Strand: Reverse

Name: hemE

Synonym: P9301_06091

Alternate gene names: 126695947

Gene position: 533341-532301 (Counterclockwise)

Preceding gene: 126695948

Following gene: 126695946

Centisome position: 32.48

GC content: 34.49

Gene sequence:

>1041_bases
ATGGGTGAAAATTTACCGCTACTTCTTTCTGCCGCATTAGGTAAAAAAGTAAATAGACCTCCAGTATGGATGATGAGGCA
AGCAGGAAGATATATGAAAATCTATAGAGATTTAAGAGAGCGTTACCCAAGTTTTAGAGAAAGGTCTGAGAATCCAGAAC
TATCATATGAGATTTCTATGCAGCCTTTTCATGCTTTCAAACCGGATGGTGTGATCCTTTTTTCAGATATTCTTACACCT
CTTCCAGGGATGGGCATCAATTTTGAAATAATAGAAAGTAAAGGTCCAATTATTGAGGACCCAATAAGAACTCTTAATCA
GGTAGAAAATTTAAAAGAATTAAGTCCAAGTGAGAGTTTAAGTTTTGTTGGTGAAGTTCTTACTTCACTAAAAAAAGATG
TGAATAATGAGGCAACAGTTTTAGGTTTTGTTGGGGCACCTTGGACTCTTGCTGCATATGTAGTTGAAGGTAAAAGCAGT
AAAAATTATTCTTTAATAAAATCAATGGCTTTTAATAAACCAGATTTACTACATAAACTCCTTGATCATTTTGCAAAATC
TATTGGTGAGTATCTTAAATATCAAATAAAATCTGGTGCGCAAGTAGTACAAATTTTTGATTCATGGGCAGGTCAACTAA
GCCCACAAGATTACGATATCTTTGCTGGGCCGTATCAAAAAAAAGTTGTTGAAATTGTAAAAGCGGAATACCCTGAAACA
CCAATAATTCTTTATATTTCAGGAAGTGCTGGTGTGCTAGAAAGAATGGCAAAAACTGGTGTAGATATAATCTCATTAGA
CTGGACAGTAGATATTGAAGAAGCTTGCAAAAGAATCCCCAGGGGGATTGGAATTCAAGGTAATGTTGACCCTGGCATTT
TATTCGGGAACAAAGAATCAATAAAAGAAAGGATAGATAATACTTTCAATAAAATTAAAGATAGGAAATATATTCTTAAT
TTGGGTCATGGGATTTTACCAGGGACTCCAGAAGAAAATGCTCAAACATTTTTTGAACATGGGAAAAAACTCACTTACTA
G

Upstream 100 bases:

>100_bases
ATATAAATGTTCACATAACGCTTTTGATATGCTTTGCATTGTAAGATTTCTAAGTTGGAATTTTTAAAAAATTTTTTTTT
ACAGCATATCGAATTGAAAA

Downstream 100 bases:

>100_bases
TCAAAATCTTGGCATATAAAAACTTATTAATAACAGGCGCTAATGGATGTGTTGGCCAATATTTAGTTGATTGGTTTTTG
AAAAACACAAAATTCAGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLNQVENLKELSPSESLSFVGEVLTSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFNKPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVEIVKAEYPET
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKESIKERIDNTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY

Sequences:

>Translated_346_residues
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLNQVENLKELSPSESLSFVGEVLTSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFNKPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVEIVKAEYPET
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKESIKERIDNTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY
>Mature_345_residues
GENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTPL
PGMGINFEIIESKGPIIEDPIRTLNQVENLKELSPSESLSFVGEVLTSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSK
NYSLIKSMAFNKPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVEIVKAEYPETP
IILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKESIKERIDNTFNKIKDRKYILNL
GHGILPGTPEENAQTFFEHGKKLTY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=33.9233038348083, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.2352941176471, Blast_Score=254, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=34.1880341880342, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=35.5882352941176, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI221330099, Length=340, Percent_Identity=35.5882352941176, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PROM0 (A3PBV7)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090833.1
- ProteinModelPortal:   A3PBV7
- SMR:   A3PBV7
- STRING:   A3PBV7
- GeneID:   4911364
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_06091
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   PMAR167546:P9301ORF_0624-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38916; Mature: 38785

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 153-153 BINDING 208-208 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLNQVENLKELSPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
SFVGEVLTSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFNKPDLLHKL
HHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEHEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVEIVKAEYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKES
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDNTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLNQVENLKELSPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
SFVGEVLTSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFNKPDLLHKL
HHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEHEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVEIVKAEYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
PIILYISGSAGVLERMAKTGVDIISLDWTVDIEEACKRIPRGIGIQGNVDPGILFGNKES
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDNTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA