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The map label for this gene is hisI [H]

Identifier: 126695942

GI number: 126695942

Start: 526996

End: 527658

Strand: Reverse

Name: hisI [H]

Synonym: P9301_06041

Alternate gene names: 126695942

Gene position: 527658-526996 (Counterclockwise)

Preceding gene: 126695944

Following gene: 126695941

Centisome position: 32.14

GC content: 31.98

Gene sequence:

>663_bases
ATGACTTATTCAACTAATTTTTCGATAGAGGATCTACGCTTTGATAATTATGGATTAATCCCTGCAATAGCACAAGATTG
GCTTGACGGATCAATTCTTATGCTTGCTTGGATGAACAAAGAATCTTTGACAATGACACTTGAAACCAAAAACGTTCATT
ATTGGAGTAGATCAAGATCCGAAATTTGGAGAAAAGGAGCTACAAGTGGAAGTACCCAAATACTTAAGGAGATAAGATTC
GACTGCGATAATGATGCACTAATCCTTTTGATTGAACAAAATGGTTCAGGAGCATGTCACACTGGCGAAAAAAGTTGTTT
TTTCAACGAAATCAAAATTAATCAAAGTGATAAAAAAGAGAAAAAAACAACTCCCTTCTCAAATATTTGCTCTGAATTAT
TTAATACAATTAACGAAAGATCAATAAATCCATCGGAAAAAAGTTACACAAATCATCTTTTAACAAAAGGTAGCAACACT
ATTTTAAAAAAAATAGGAGAGGAATCTGCAGAATTTATAATGGCTTGCAAAGATAATGATAAAAATTCAATCTCAAATGA
AGCTGCTGATTTAATTTATCATTTACAGGTAGCTCTTATGCACAAGGGAGTTAACTGGAGAGATGTACTTGCTGTTCTAG
AATCAAGAAGAAATAATAATTAA

Upstream 100 bases:

>100_bases
TTTTGCTGCATGAAAATTTCAGAGAATGAATATACATCAATTAACTGTTAGGATAATTTTTAATAAAACACATTGAGTAG
GATTTAACATAGCCAACATA

Downstream 100 bases:

>100_bases
AATTCAGAGATTTTAATTTTTTAAATCTAAAAATATGAGGGAAAAATATAAAATAATTAATTAATAATTATTAATTAATT
ATTAATTAATTATTACATGT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTYSTNFSIEDLRFDNYGLIPAIAQDWLDGSILMLAWMNKESLTMTLETKNVHYWSRSRSEIWRKGATSGSTQILKEIRF
DCDNDALILLIEQNGSGACHTGEKSCFFNEIKINQSDKKEKKTTPFSNICSELFNTINERSINPSEKSYTNHLLTKGSNT
ILKKIGEESAEFIMACKDNDKNSISNEAADLIYHLQVALMHKGVNWRDVLAVLESRRNNN

Sequences:

>Translated_220_residues
MTYSTNFSIEDLRFDNYGLIPAIAQDWLDGSILMLAWMNKESLTMTLETKNVHYWSRSRSEIWRKGATSGSTQILKEIRF
DCDNDALILLIEQNGSGACHTGEKSCFFNEIKINQSDKKEKKTTPFSNICSELFNTINERSINPSEKSYTNHLLTKGSNT
ILKKIGEESAEFIMACKDNDKNSISNEAADLIYHLQVALMHKGVNWRDVLAVLESRRNNN
>Mature_219_residues
TYSTNFSIEDLRFDNYGLIPAIAQDWLDGSILMLAWMNKESLTMTLETKNVHYWSRSRSEIWRKGATSGSTQILKEIRFD
CDNDALILLIEQNGSGACHTGEKSCFFNEIKINQSDKKEKKTTPFSNICSELFNTINERSINPSEKSYTNHLLTKGSNTI
LKKIGEESAEFIMACKDNDKNSISNEAADLIYHLQVALMHKGVNWRDVLAVLESRRNNN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=201, Percent_Identity=35.8208955223881, Blast_Score=124, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319819, Length=177, Percent_Identity=34.4632768361582, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 25084; Mature: 24952

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSTNFSIEDLRFDNYGLIPAIAQDWLDGSILMLAWMNKESLTMTLETKNVHYWSRSRS
CCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEHHCCHH
EIWRKGATSGSTQILKEIRFDCDNDALILLIEQNGSGACHTGEKSCFFNEIKINQSDKKE
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCHH
KKTTPFSNICSELFNTINERSINPSEKSYTNHLLTKGSNTILKKIGEESAEFIMACKDND
HCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHEEEEECCCC
KNSISNEAADLIYHLQVALMHKGVNWRDVLAVLESRRNNN
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TYSTNFSIEDLRFDNYGLIPAIAQDWLDGSILMLAWMNKESLTMTLETKNVHYWSRSRS
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEHHCCHH
EIWRKGATSGSTQILKEIRFDCDNDALILLIEQNGSGACHTGEKSCFFNEIKINQSDKKE
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCHH
KKTTPFSNICSELFNTINERSINPSEKSYTNHLLTKGSNTILKKIGEESAEFIMACKDND
HCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHEEEEECCCC
KNSISNEAADLIYHLQVALMHKGVNWRDVLAVLESRRNNN
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]