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The map label for this gene is ecm27 [H]

Identifier: 126695932

GI number: 126695932

Start: 520238

End: 521317

Strand: Reverse

Name: ecm27 [H]

Synonym: P9301_05941

Alternate gene names: 126695932

Gene position: 521317-520238 (Counterclockwise)

Preceding gene: 126695937

Following gene: 126695930

Centisome position: 31.75

GC content: 31.67

Gene sequence:

>1080_bases
ATGAATGATTTTTTATTTCCAATAATAGAAATAGTTTTAGGCGTAGTTCTACTTTTTGCGGGAGGAGAGTTATTCATCCA
AGGAGCTATATTTTTATCTTTAATTTTAGGAATACCTCAAATAGTAATTGGTTTAACAGTTGTTTCTTTTGGAACAAGCT
CTCCTGAGTTGTTAGTAAGTTTAAGTTCAATTTTTAAAGGCAGTGATTCGCTTGCGGCAAGCAATGTAATTGGAAGCAAT
ATTTTTAATGTTCTCGTTGTTTTGGGCATAAGCTCATTGATAACACCTCTTAAGGTAAAAAGCAGAATAGTTAGGAGGGA
TGTGCCTCTTTTAATGGCAATTTCATCTGCAGTTTGGGCTATGTCATCAACAGGCTTATTAACATTGCAAGCAGGGATAT
TTCTAATATTTTGTTTAATCTTAAATACATTATGGGAAATCAACACCATGAATGAGAAAGGGGAGGAGACAAAAGATGCT
GAACCAGAGATAGAAGAATTAACGGATAACTATAAAGGGAAGCTTAATATCCTACTAAAGTTAATATTGGGAATATTTCT
TTTAAGCTTTGGTTCAAATATTTTAGTAAATGGTTCTCAAACGCTTGCTAATCTTTTGGGTGTAAATGAAATTGTTATCG
GTTTAACTATCGTAGCAACTGGGACATCTTTACCAGAATTAGTAACTTCAATAATTGCTGCATTTAAAGGTAAAACAGAT
CTTGCGATTGGGAATGTAGTAGGAAGCAATTTGCTCAATCAACTACTTATCCTTGGAAGTTGCAGTATTTTTTCAGGATT
TAAAGGTTTAGTAATTGAACAAAGTCTAATAAAAGTTGACTTACCTTTTATGGTTTTAACTACCTTTGCATGTTTACCAA
TTTTCTGGAGCAAAGGGAAAATCACCAGAATTGAAGGATTTATTTTGCTTAACCTTTATATTTTCTACATTCTCGATAAG
ATTCTTTTCCTGAATGGATTTAACTTCCTTTCTGAGTTAAGGATAGGATTATTTATTTATTTTGCTTTACTTACAGTGTT
TCTGATAGTTCAAGAAAAATTAAAATTTTCTAATTCATAA

Upstream 100 bases:

>100_bases
AAATTAAAATTGACAATAAATTATAGATATTCGAGGATAGTTATTAATCAATTTACTAATCAATTATGAGAATTTTTATT
ATCTTAATTAAAGCCTAAAT

Downstream 100 bases:

>100_bases
TATTATCCATACATAGTCACAAATTCTTCTGAGATAGTTGGGTGCAAAGCCATAGTAATGTCAAAATCTTTTTTTGTTAT
TCCTGCATTTAATGAAACTG

Product: CaCA family sodium/calcium exchanger

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNDFLFPIIEIVLGVVLLFAGGELFIQGAIFLSLILGIPQIVIGLTVVSFGTSSPELLVSLSSIFKGSDSLAASNVIGSN
IFNVLVVLGISSLITPLKVKSRIVRRDVPLLMAISSAVWAMSSTGLLTLQAGIFLIFCLILNTLWEINTMNEKGEETKDA
EPEIEELTDNYKGKLNILLKLILGIFLLSFGSNILVNGSQTLANLLGVNEIVIGLTIVATGTSLPELVTSIIAAFKGKTD
LAIGNVVGSNLLNQLLILGSCSIFSGFKGLVIEQSLIKVDLPFMVLTTFACLPIFWSKGKITRIEGFILLNLYIFYILDK
ILFLNGFNFLSELRIGLFIYFALLTVFLIVQEKLKFSNS

Sequences:

>Translated_359_residues
MNDFLFPIIEIVLGVVLLFAGGELFIQGAIFLSLILGIPQIVIGLTVVSFGTSSPELLVSLSSIFKGSDSLAASNVIGSN
IFNVLVVLGISSLITPLKVKSRIVRRDVPLLMAISSAVWAMSSTGLLTLQAGIFLIFCLILNTLWEINTMNEKGEETKDA
EPEIEELTDNYKGKLNILLKLILGIFLLSFGSNILVNGSQTLANLLGVNEIVIGLTIVATGTSLPELVTSIIAAFKGKTD
LAIGNVVGSNLLNQLLILGSCSIFSGFKGLVIEQSLIKVDLPFMVLTTFACLPIFWSKGKITRIEGFILLNLYIFYILDK
ILFLNGFNFLSELRIGLFIYFALLTVFLIVQEKLKFSNS
>Mature_359_residues
MNDFLFPIIEIVLGVVLLFAGGELFIQGAIFLSLILGIPQIVIGLTVVSFGTSSPELLVSLSSIFKGSDSLAASNVIGSN
IFNVLVVLGISSLITPLKVKSRIVRRDVPLLMAISSAVWAMSSTGLLTLQAGIFLIFCLILNTLWEINTMNEKGEETKDA
EPEIEELTDNYKGKLNILLKLILGIFLLSFGSNILVNGSQTLANLLGVNEIVIGLTIVATGTSLPELVTSIIAAFKGKTD
LAIGNVVGSNLLNQLLILGSCSIFSGFKGLVIEQSLIKVDLPFMVLTTFACLPIFWSKGKITRIEGFILLNLYIFYILDK
ILFLNGFNFLSELRIGLFIYFALLTVFLIVQEKLKFSNS

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI300797277, Length=247, Percent_Identity=26.7206477732794, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI300797299, Length=247, Percent_Identity=26.7206477732794, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789587, Length=235, Percent_Identity=35.3191489361702, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 38978; Mature: 38978

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFLFPIIEIVLGVVLLFAGGELFIQGAIFLSLILGIPQIVIGLTVVSFGTSSPELLVS
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LSSIFKGSDSLAASNVIGSNIFNVLVVLGISSLITPLKVKSRIVRRDVPLLMAISSAVWA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MSSTGLLTLQAGIFLIFCLILNTLWEINTMNEKGEETKDAEPEIEELTDNYKGKLNILLK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
LILGIFLLSFGSNILVNGSQTLANLLGVNEIVIGLTIVATGTSLPELVTSIIAAFKGKTD
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCC
LAIGNVVGSNLLNQLLILGSCSIFSGFKGLVIEQSLIKVDLPFMVLTTFACLPIFWSKGK
HHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
ITRIEGFILLNLYIFYILDKILFLNGFNFLSELRIGLFIYFALLTVFLIVQEKLKFSNS
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNDFLFPIIEIVLGVVLLFAGGELFIQGAIFLSLILGIPQIVIGLTVVSFGTSSPELLVS
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LSSIFKGSDSLAASNVIGSNIFNVLVVLGISSLITPLKVKSRIVRRDVPLLMAISSAVWA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MSSTGLLTLQAGIFLIFCLILNTLWEINTMNEKGEETKDAEPEIEELTDNYKGKLNILLK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
LILGIFLLSFGSNILVNGSQTLANLLGVNEIVIGLTIVATGTSLPELVTSIIAAFKGKTD
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCC
LAIGNVVGSNLLNQLLILGSCSIFSGFKGLVIEQSLIKVDLPFMVLTTFACLPIFWSKGK
HHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
ITRIEGFILLNLYIFYILDKILFLNGFNFLSELRIGLFIYFALLTVFLIVQEKLKFSNS
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]