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The map label for this gene is hbd [H]

Identifier: 126698642

GI number: 126698642

Start: 1250840

End: 1251685

Strand: Direct

Name: hbd [H]

Synonym: CD1058

Alternate gene names: 126698642

Gene position: 1250840-1251685 (Clockwise)

Preceding gene: 126698641

Following gene: 126698643

Centisome position: 29.16

GC content: 29.2

Gene sequence:

>846_bases
ATGAAATTAGCTGTAATAGGTAGTGGAACTATGGGAAGTGGTATTGTACAAACTTTTGCAAGTTGTGGACATGATGTATG
TTTAAAGAGTAGAACTCAAGGTGCTATAGATAAATGTTTAGCTTTATTAGATAAAAATTTAACTAAGTTAGTTACTAAGG
GAAAAATGGATGAAGCTACAAAAGCAGAAATATTAAGTCATGTTAGTTCAACTACTAATTATGAAGATTTAAAAGATATG
GATTTAATAATAGAAGCATCTGTAGAAGACATGAATATAAAGAAAGATGTTTTCAAGTTACTAGATGAATTATGTAAAGA
AGATACTATCTTGGCAACAAATACTTCATCATTATCTATAACAGAAATAGCTTCTTCTACTAAGAGACCAGATAAAGTTA
TAGGAATGCATTTCTTTAATCCAGTTCCTATGATGAAATTAGTTGAAGTTATAAGTGGTCAGTTAACATCAAAAGTTACT
TTTGATACAGTATTTGAATTATCTAAGAGTATCAATAAAGTACCAGTAGATGTATCTGAATCTCCTGGATTTGTAGTAAA
TAGAATACTTATACCTATGATAAATGAAGCTGTTGGTATATATGCAGATGGTGTTGCAAGTAAAGAAGAAATAGATGAAG
CTATGAAATTAGGAGCAAACCATCCAATGGGACCACTAGCATTAGGTGATTTAATTGGATTAGATGTTGTTTTAGCTATA
ATGAACGTTTTATATACTGAATTTGGAGATACTAAATATAGACCTCATCCACTTTTAGCTAAAATGGTTAGAGCTAATCA
ATTAGGAAGAAAAACTAAGATAGGATTCTATGATTATAATAAATAA

Upstream 100 bases:

>100_bases
TAAAAATCTAATTAAAAATATATTTGCTGTTAACTAGATTAAATAGTATTTTAATCTAGTTAACAGAATATAAATACTAA
AATAACAGGAGGTTATAACT

Downstream 100 bases:

>100_bases
GAATTTGGGAATTAAAAGTTTAAATAAAATTGTTTAAAAAACAATTTCGGATATATGAAAAATCTAATTTAATGGGGGTA
ATGAATATGAGAGAAGTAGT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDM
DLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAI
MNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK

Sequences:

>Translated_281_residues
MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDM
DLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAI
MNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK
>Mature_281_residues
MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDM
DLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAI
MNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=43.859649122807, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=41.3907284768212, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI20127408, Length=280, Percent_Identity=35.3571428571429, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI261878539, Length=305, Percent_Identity=38.3606557377049, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI68989263, Length=305, Percent_Identity=38.3606557377049, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=29.5652173913043, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787661, Length=279, Percent_Identity=41.2186379928315, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=35.8490566037736, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790281, Length=240, Percent_Identity=34.5833333333333, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=285, Percent_Identity=41.0526315789474, Blast_Score=226, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.6306620209059, Blast_Score=209, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=284, Percent_Identity=39.0845070422535, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71985923, Length=278, Percent_Identity=35.2517985611511, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.1063829787234, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=35.1254480286738, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=35.1254480286738, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=35.1254480286738, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=278, Percent_Identity=32.7338129496403, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI193203623, Length=190, Percent_Identity=30.5263157894737, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=190, Percent_Identity=30.5263157894737, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583077, Length=280, Percent_Identity=34.6428571428571, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24583079, Length=280, Percent_Identity=34.6428571428571, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI19921000, Length=280, Percent_Identity=34.6428571428571, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI20129993, Length=220, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=28.3898305084746, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30679; Mature: 30679

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEAT
CEEEEEECCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
KAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSI
HHHHHHHHHHCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCH
TEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSE
HHHHHCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAI
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCC
>Mature Secondary Structure
MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDKNLTKLVTKGKMDEAT
CEEEEEECCCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
KAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSI
HHHHHHHHHHCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCH
TEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSE
HHHHHCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAI
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8001771 [H]