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The map label for this gene is thlA1

Identifier: 126698643

GI number: 126698643

Start: 1251772

End: 1252947

Strand: Direct

Name: thlA1

Synonym: CD1059

Alternate gene names: 126698643

Gene position: 1251772-1252947 (Clockwise)

Preceding gene: 126698642

Following gene: 126698644

Centisome position: 29.18

GC content: 36.05

Gene sequence:

>1176_bases
ATGAGAGAAGTAGTAATTGCCAGTGCAGCTAGAACAGCAGTAGGAAGTTTTGGAGGAGCATTTAAATCAGTTTCAGCGGT
AGAGTTAGGGGTAACAGCAGCTAAAGAAGCTATAAAAAGAGCTAACATAACTCCAGATATGATAGATGAATCTCTTTTAG
GGGGAGTACTTACAGCAGGTCTTGGACAAAATATAGCAAGACAAATAGCATTAGGAGCAGGAATACCAGTAGAAAAACCA
GCTATGACTATAAATATAGTTTGTGGTTCTGGATTAAGATCTGTTTCAATGGCATCTCAACTTATAGCATTAGGTGATGC
TGATATAATGTTAGTTGGTGGAGCTGAAAACATGAGTATGTCTCCTTATTTAGTACCAAGTGCGAGATATGGTGCAAGAA
TGGGTGATGCTGCTTTTGTTGATTCAATGATAAAAGATGGATTATCAGACATATTTAATAACTATCACATGGGTATTACT
GCTGAAAACATAGCAGAGCAATGGAATATAACTAGAGAAGAACAAGATGAATTAGCTCTTGCAAGTCAAAATAAAGCTGA
AAAAGCTCAAGCTGAAGGAAAATTTGATGAAGAAATAGTTCCTGTTGTTATAAAAGGAAGAAAAGGTGACACTGTAGTAG
ATAAAGATGAATATATTAAGCCTGGCACTACAATGGAGAAACTTGCTAAGTTAAGACCTGCATTTAAAAAAGATGGAACA
GTTACTGCTGGTAATGCATCAGGAATAAATGATGGTGCTGCTATGCTAGTAGTAATGGCTAAAGAAAAAGCTGAAGAACT
AGGAATAGAGCCTCTTGCAACTATAGTTTCTTATGGAACAGCTGGTGTTGACCCTAAAATAATGGGATATGGACCAGTTC
CAGCAACTAAAAAAGCTTTAGAAGCTGCTAATATGACTATTGAAGATATAGATTTAGTTGAAGCTAATGAGGCATTTGCT
GCCCAATCTGTAGCTGTAATAAGAGACTTAAATATAGATATGAATAAAGTTAATGTTAATGGTGGAGCAATAGCTATAGG
ACATCCAATAGGATGCTCAGGAGCAAGAATACTTACTACACTTTTATATGAAATGAAGAGAAGAGATGCTAAAACTGGTC
TTGCTACACTTTGTATAGGTGGTGGAATGGGAACTACTTTAATAGTTAAGAGATAG

Upstream 100 bases:

>100_bases
ATTATAATAAATAAGAATTTGGGAATTAAAAGTTTAAATAAAATTGTTTAAAAAACAATTTCGGATATATGAAAAATCTA
ATTTAATGGGGGTAATGAAT

Downstream 100 bases:

>100_bases
TTTTAGATTATAATATTTACAAATTAAATATTTAATTATGAATTTAACCTGTAAGAATAACAAATAGTTATTCTTACAGG
TTTTTATAGTTAAAAATAAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKP
AMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGT
VTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFA
AQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR

Sequences:

>Translated_391_residues
MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKP
AMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGT
VTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFA
AQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR
>Mature_391_residues
MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKP
AMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGT
VTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFA
AQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=50.7692307692308, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=43.2225063938619, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=42.8934010152284, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=42.0654911838791, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=32, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.9462915601023, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=55.8673469387755, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=50.1278772378517, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=43, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=43.5643564356436, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=33.0073349633252, Blast_Score=204, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=46.7866323907455, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=42.8571428571429, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=40.5128205128205, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.3953488372093, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=30.4785894206549, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=43.25, Blast_Score=318, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=39.3483709273183, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=53.7084398976982, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=44.2455242966752, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=40.920716112532, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.7647058823529, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THLA_CLOD6 (Q18AR0)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087540.1
- ProteinModelPortal:   Q18AR0
- SMR:   Q18AR0
- STRING:   Q18AR0
- GeneID:   4915191
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1059
- NMPDR:   fig|1496.1.peg.3819
- eggNOG:   COG0183
- HOGENOM:   HBG370930
- OMA:   AMTINIV
- ProtClustDB:   CLSK2534674
- GO:   GO:0005737
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.9

Molecular weight: Translated: 40861; Mature: 40861

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2

Important sites: ACT_SITE 88-88 ACT_SITE 348-348 ACT_SITE 378-378

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAG
CCCEEEEHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSM
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
SPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGITAENIAEQWNITREEQDELAL
CCEECCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCHHHHHHH
ASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGT
HCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCHHHCCCC
VTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKAL
EEECCCCCCCCCCEEEEEEEHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
EAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTT
HHHCCEEECCEEEECCHHHHHHHHHHHEECCCCEEEEEECCCEEEECCCCCCCHHHHHHH
LLYEMKRRDAKTGLATLCIGGGMGTTLIVKR
HHHHHHHHHHHCCEEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANITPDMIDESLLGGVLTAG
CCCEEEEHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLIALGDADIMLVGGAENMSM
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
SPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGITAENIAEQWNITREEQDELAL
CCEECCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCHHHHHHH
ASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEYIKPGTTMEKLAKLRPAFKKDGT
HCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCHHHCCCC
VTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIMGYGPVPATKKAL
EEECCCCCCCCCCEEEEEEEHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
EAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDMNKVNVNGGAIAIGHPIGCSGARILTT
HHHCCEEECCEEEECCHHHHHHHHHHHEECCCCEEEEEECCCEEEECCCCCCCHHHHHHH
LLYEMKRRDAKTGLATLCIGGGMGTTLIVKR
HHHHHHHHHHHCCEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA