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The map label for this gene is fumB [H]

Identifier: 126698588

GI number: 126698588

Start: 1173005

End: 1173553

Strand: Direct

Name: fumB [H]

Synonym: CD1004

Alternate gene names: 126698588

Gene position: 1173005-1173553 (Clockwise)

Preceding gene: 126698587

Following gene: 126698589

Centisome position: 27.34

GC content: 32.97

Gene sequence:

>549_bases
ATGATAAAAATAACTACACCTGTAAATGAAATTGATATAGCAAAATTAAATTGTGGAGATACAATTAGTTTGAGTGGTAT
ACTTTATACAGCAAGAGATGCTGCTCATAAAAGATTGATAGATTGTATAAATAAAGGTGAAGAATTACCATTTGACGTAT
ATGGTCAAGGAATATATTATGTAGGACCTACTCCTACAAAGCCAGGAGAAGTTATAGGTGCTGCAGGTCCAACGACGAGT
TATAGAATGGATGATTTGACTATACCTCTTTTAGAAAGAGGTCTTAGATTGATGATAGGCAAGGGAAAAAGAAGTGATGA
GGTTATAGAAGGTATGCAAAAATACGGAGCAGTTTATCTTGCTGCAATAGGAGGAGCTGGAGCGTATATTTCAAATTCAA
TAAAATCATGTGAAATTATTGCATATGAAGATTTAGGAGCTGAAGCTATAAGAAAGATTGTAGTAGAAGACCTTAAACTT
ACAGTAGCAATAGATAGCTATGGAAATAATATATATGAGCAAGGTCGAGCAATTTATGAATGTAAATAA

Upstream 100 bases:

>100_bases
AGAGACTTTTCCTACACACATAGCAGGTCTACCTGTTGTTGTAAATATAAACTGCCATGCATCAAGACATAAGAAGGTAG
TAATTTAGGAGGAAAATAAA

Downstream 100 bases:

>100_bases
TGTTTAGAAATAAATATGAATATCAAAATTAAAAATAGTTGTGTATATTTTAAGGAGGAAAATTGATGTCTAAGGATTAT
GCAAAATTGGCATTAGAAAT

Product: fumarate hydratase subunit B

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCINKGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTS
YRMDDLTIPLLERGLRLMIGKGKRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
TVAIDSYGNNIYEQGRAIYECK

Sequences:

>Translated_182_residues
MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCINKGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTS
YRMDDLTIPLLERGLRLMIGKGKRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
TVAIDSYGNNIYEQGRAIYECK
>Mature_182_residues
MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCINKGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTS
YRMDDLTIPLLERGLRLMIGKGKRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
TVAIDSYGNNIYEQGRAIYECK

Specific function: It functions in the generation of fumarate for use as an anaerobic electron acceptor [H]

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1790564, Length=178, Percent_Identity=38.2022471910112, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787897, Length=177, Percent_Identity=37.2881355932203, Blast_Score=116, Evalue=7e-28,
Organism=Escherichia coli, GI1789443, Length=181, Percent_Identity=30.939226519337, Blast_Score=100, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167
- InterPro:   IPR020557 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 19744; Mature: 19744

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCINKGEELPFDVYGQGIYY
CEEECCCCCCEEEEEECCCCEEEECEEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCEEE
VGPTPTKPGEVIGAAGPTTSYRMDDLTIPLLERGLRLMIGKGKRSDEVIEGMQKYGAVYL
ECCCCCCCCCEEECCCCCCCEEECCEEHHHHHCCEEEEECCCCCCHHHHHHHHHHCEEEE
AAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKLTVAIDSYGNNIYEQGRAIYE
EEECCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHCEEEEEEEECCCCHHHHCCCEEEE
CK
CC
>Mature Secondary Structure
MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCINKGEELPFDVYGQGIYY
CEEECCCCCCEEEEEECCCCEEEECEEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCEEE
VGPTPTKPGEVIGAAGPTTSYRMDDLTIPLLERGLRLMIGKGKRSDEVIEGMQKYGAVYL
ECCCCCCCCCEEECCCCCCCEEECCEEHHHHHCCEEEEECCCCCCHHHHHHHHHHCEEEE
AAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKLTVAIDSYGNNIYEQGRAIYE
EEECCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHCEEEEEEEECCCCHHHHCCCEEEE
CK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2656658; 7610040; 9278503 [H]