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The map label for this gene is mmlH [H]

Identifier: 126446309

GI number: 126446309

Start: 1357362

End: 1358786

Strand: Direct

Name: mmlH [H]

Synonym: BMA10247_A1391

Alternate gene names: 126446309

Gene position: 1357362-1358786 (Clockwise)

Preceding gene: 126445713

Following gene: 126446438

Centisome position: 57.69

GC content: 71.72

Gene sequence:

>1425_bases
ATGGAGCAGCGTGCGGCGCGCATGGCGAGCAGCGCCCGACAGGAGACGACAGTGTTCACATGGTTCGCCGCCGTATCGCC
GCGCGAACGGCGCACGTTCTGGGCCTGCTTCGGCGGCTGGGCGCTCGATGCGCTCGACATGCAGATGTTCAGCCTCGTGA
TCCCCGCGATCGTCGCCGAATGGTCGCTGTCGCGCACGCAGGCGGGCTTCGTCGGCGGCGCGACGCTCGTCGCGTCGGCG
CTCGGCGGCTGGGTGGCCGGCATGCTGTCCGACCGCTTCGGCCGCGTGCGGACGCTGCAATGGACGATCGCGTGCTTCTC
GGTCGGCACGTTCGCCTGCGCGTTCGCGACGAGCTACCCGCAATTCGTGACCCTGAAGACGCTGCAGGGCCTCGGCTTCG
GCGGCGAATGGGCGGCGGGCGCCGTGCTGATGGCGGAGACGATCCGCGCCGAGCACCGCGGCAAGGCGATGGGCGCCGTG
CAGAGCGCATGGGCGCTCGGCTGGGGGAGCGCCGTGCTGCTTTATGCGCTCGCGTTCTCGCTGCTGCCCGCCGAGCTCGC
ATGGCGCGCGATGTTCGCCATCGGGCTGCTGCCGGCGCTGCTGATCGTCTATGTGCGGCGCGGGATTGCCGAGCCTTCGG
CGCGCGCCTTGAATCCGTCCGGGCCGTGCGATCCGCCCGAGCCGCCCAATTCGCCGGACGGAGCACCTCCGTCGGGCGCG
TCGCCGGCGGTGCGGGCGAGCGCCCCGCTCGTCGGCATCTTCTCGCGCGGCACCCGGCGCATGACGCTGATCGGCGCGCT
GCTCGGCGTCGGCGCGCACGGCGGCTATTACGCGCTGATGACGTGGCTGCCGACCTATCTGAAAACCGAGCGGCATCTGT
CGGTGCTCGGCACGGGCGGCTATCTCGCCGTCATCATCGTCGCGTTCTTCTGCGGCTGCCTCGCGAGCGCGCAGTTGCTC
GACCTCATCGGTCGACGCGGCACGATCCTCGCGTTCGCCGCGTGCTGCGTCGGCACGGTGATCCTCTACCTGTTCGCGCC
GCTCGGCAACGCGGCGATGCTCGCGCTCGGCTTTGCGCTCGGCTTTTTCGCGGCGGGCATCCCGGCAAGCATGGGCGCGC
TGTTCAACGAAATGTATCCGCGCGGCACGCGCGGCACGGGCGTCGGCTTTTGCTACAACTTCGGGCGCGTCGCATCGGCG
GGCTTTCCGGTGCTGGTCGGGCACATGTCGGCCGGCATGCCGCTCGGCACCGCGATCGGCATCGGCGCGGCGGTCGCCTA
TTCGATCGTCGTCGTCGCCGTGCTGATGCTGCCCGAGACGCGCGGGCGCACGCTCGACGATTGCGCGAGCGCGGATGCCG
ACGCCGCCCGCGCGGGCGCCGGGCGCATCGGTGCGCCGGCAGCGCCGGGCGCGCGGCATCGCTGA

Upstream 100 bases:

>100_bases
GCCCCGCGAGCGAATTCATCTATCAGGCGGAAATCCGCTAGCGGCCGGCTCGCGCGACAGCGGAGCTCGCGCACGGGCCG
CGCGCTCGCGCGAGCAACGC

Downstream 100 bases:

>100_bases
AGTTCGCGCCGGATTCAGGTCGGCGGTTCGTGGCATGAGGAGCATCGAGCATTGAGCGAGCAAGAATGGAACGCGTTCGC
GCCCGCGGCGGCGGCGCCGC

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MEQRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRTLQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRAMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DLIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR

Sequences:

>Translated_474_residues
MEQRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRTLQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRAMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DLIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
>Mature_474_residues
MEQRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRTLQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRAMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DLIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=469, Percent_Identity=25.3731343283582, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI213021148, Length=442, Percent_Identity=22.1719457013575, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082231, Length=479, Percent_Identity=25.4697286012526, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082404, Length=420, Percent_Identity=23.3333333333333, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786229, Length=444, Percent_Identity=22.972972972973, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081723, Length=420, Percent_Identity=27.8571428571429, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082159, Length=366, Percent_Identity=25.6830601092896, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790550, Length=414, Percent_Identity=24.6376811594203, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=439, Percent_Identity=23.9179954441913, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49304; Mature: 49304

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAE
CCHHHHHHHHHHHHHHEEEEEEECCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WSLSRTQAGFVGGATLVASALGGWVAGMLSDRFGRVRTLQWTIACFSVGTFACAFATSYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCC
QFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAVQSAWALGWGSAVLLYALAFS
CEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAELAWRAMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGG
CCCCCCCCCEEEHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCH
YLAVIIVAFFCGCLASAQLLDLIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIG
HHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHCCCCCEEEHHHHCCCCCHHHHH
IGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAE
CCHHHHHHHHHHHHHHEEEEEEECCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WSLSRTQAGFVGGATLVASALGGWVAGMLSDRFGRVRTLQWTIACFSVGTFACAFATSYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCC
QFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAVQSAWALGWGSAVLLYALAFS
CEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAELAWRAMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGG
CCCCCCCCCEEEHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCH
YLAVIIVAFFCGCLASAQLLDLIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIG
HHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHCCCCCEEEHHHHCCCCCHHHHH
IGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]