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The map label for this gene is icsB

Identifier: 126446067

GI number: 126446067

Start: 706463

End: 708001

Strand: Direct

Name: icsB

Synonym: BMA10247_A0764

Alternate gene names: 126446067

Gene position: 706463-708001 (Clockwise)

Preceding gene: 126447736

Following gene: 126446805

Centisome position: 30.03

GC content: 67.77

Gene sequence:

>1539_bases
ATGATCAATGTCGGTGCATTCGTCGCAAGCGCGCGATCCGGCGCGCGTGTCGTCGTCGGCGGCGACGCGCGCGGCCCGGT
GGTGTCGGCCGCGAGGTTGGGGATGAAGGAGCGGTTGTTCGCGTTTCTCGCGCACGTGCCGCTGCTCAAGCACTGCGATG
CGGTGCGGCGCTATGCGGAGCAGGTTCGCATGGAAAACCGCCGCTCGCTCGAGGTGTTCGTGCTCGCGCTGTCGAAGCGA
TATGGCCCGGAAGGCGCGAAGGCGGCGTTCGACTACGGCGCGCGGCGCGACGGCGCGCCGCTCGATCAGCGGCGCGTGCG
CAACATGGTGTCGATCGCCGAGCACTTCCACGGCACGGGCGACGCGAAGCCGCTCGCCCGGCAAATGGTATTTCGGTCGT
GGGAATGCCGGGGGCTCGATCATCCGGGGCACGCGTCGCTGACGATCAAGAATCAGGCGGACGCCGATGCCGGCCGGCAC
GTGTACGAGCACGTCAGTTGGTGGCCGAATCAACGACTGGGTAGTAAGGAGCATTTCGATCGCATCGAACCGAAGACGCT
GGACGGCTATCGGATCGACAAGCGCTCGGAGATTTCGAGCGCGACGGAACAGAGGCTTCGCGAAGGCGACGCGGCGAGGA
GAAAGATCCTCGCGGACGGCTTCAAATACGCGAATCAGGACGAGCGTCACGACGCGCTTTTTTTTCCGAGAGCCGGCCAG
AAGTTGGACAAGGATGCCGAATGGGGGCTGAGCGCGCGCAAGGTCTATTTTCCGGCGATCGGATTCAACCACGACAGGCG
CGATACGGACCGCCCGCGCGCGTTCGTGCTGTTCGGGCTGAACGAGGCGGCGATGTTGCGCGATGCGCGCACCGTGAAGG
AAGGCGCGAAGTCAGGCGAGCTCAAGTATCGAATGATCAGCAAGAAGGAAAACTGCGCGTCGATGGCGCTGCGCGTGCTG
CGCGCCGGCGGCGCCGAGCATTTCGTGCCGTATACGGCCGCATGGATCTCCGAGGATCCGAATCACGCGCACGCCTATGC
GCTGGCCGTGCAGGCGAGGATCGACGCGCTGAACCAGCGGCGTGCCGACGTCGAGCGCCGCTGCGAGCGGTTGCGCGACA
GCGCATCGGTGCGGCAGGCGTGGCGCGCGTTCTCCGAGGCCGGCGGTGCCTCGGCAAGCCCGCTCGCGGAGGACGCCGGC
CGCGGGCGAGCATCGGCGCACATGCGGCAGGCGCGGCTCGACGAGCATGCGCGCGAGGTCGAGCGAATCGGCGCGTATTT
CGCCGAGCTGTCCGCCGGGCGATCCGGCAAGCATCGCGATCGGGCGGATGCGGATCTGGCCGATGCGATGAAGCGTTGCG
CGCCTTCGGCTCGCGACGACGTCGCGGCGCTGACGCGCAAGGCGAGCGTGCTCGTCGAGACGCTCGGCCGGCATCTCGAC
GCGCCGCCGCCGAGCGATTCGTCCGCGCTGAGGAGGCTGGCCGCGCACGCGATGATCGGCCGGATCGAGGCGTTCATGGC
GGCTGCGATCGCCGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCCCGGCGGGCGACGGCCTGCTCGGCAGCCACGCGCGGCGGCCTTGCGCGGCCGCCGCGCCGTATCGGGATGTCTG
GAAGTCGATGGGAGGAGTGG

Downstream 100 bases:

>100_bases
AGACCGCCTGAAGACAGCATGAAGACCGCATAGAGAACGAGCGAAGGGCGCGCCGGGCGCGCGCAGCCGTGCGTCGCGCG
GCGGCGCGCGGCTGATTCGA

Product: virulence protein IcsB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MINVGAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAEQVRMENRRSLEVFVLALSKR
YGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTGDAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRH
VYEHVSWWPNQRLGSKEHFDRIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDALFFPRAGQ
KLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGELKYRMISKKENCASMALRVL
RAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQRRADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAG
RGRASAHMRQARLDEHAREVERIGAYFAELSAGRSGKHRDRADADLADAMKRCAPSARDDVAALTRKASVLVETLGRHLD
APPPSDSSALRRLAAHAMIGRIEAFMAAAIAA

Sequences:

>Translated_512_residues
MINVGAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAEQVRMENRRSLEVFVLALSKR
YGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTGDAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRH
VYEHVSWWPNQRLGSKEHFDRIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDALFFPRAGQ
KLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGELKYRMISKKENCASMALRVL
RAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQRRADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAG
RGRASAHMRQARLDEHAREVERIGAYFAELSAGRSGKHRDRADADLADAMKRCAPSARDDVAALTRKASVLVETLGRHLD
APPPSDSSALRRLAAHAMIGRIEAFMAAAIAA
>Mature_512_residues
MINVGAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAEQVRMENRRSLEVFVLALSKR
YGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTGDAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRH
VYEHVSWWPNQRLGSKEHFDRIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDALFFPRAGQ
KLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGELKYRMISKKENCASMALRVL
RAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQRRADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAG
RGRASAHMRQARLDEHAREVERIGAYFAELSAGRSGKHRDRADADLADAMKRCAPSARDDVAALTRKASVLVETLGRHLD
APPPSDSSALRRLAAHAMIGRIEAFMAAAIAA

Specific function: Plays a role in mediating bacterial evasion from the host autophagic pathway

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the bsa type III secretion system (By similarity)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BopA/IcsB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BOPA_BURM7 (A3MCH8)

Other databases:

- EMBL:   CP000547
- RefSeq:   YP_001077964.1
- ProteinModelPortal:   A3MCH8
- SMR:   A3MCH8
- GeneID:   4890966
- GenomeReviews:   CP000547_GR
- KEGG:   bmn:BMA10247_A0764
- TIGR:   BMA10247_A0764
- HOGENOM:   HBG042552
- OMA:   KSENCAG
- ProtClustDB:   CLSK688131
- BioCyc:   BMAL320389:BMA10247_A0764-MONOMER
- GO:   GO:0009405
- InterPro:   IPR011070
- InterPro:   IPR015203

Pfam domain/function: PF09119 SicP-binding; SSF56568 AlphaBeta_subunt

EC number: NA

Molecular weight: Translated: 56801; Mature: 56801

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVGAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAE
CCCCHHHHHHCCCCCEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
QVRMENRRSLEVFVLALSKRYGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTG
HHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRHVYEHVSWWPNQRLGSKEHFD
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
RIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDALFFPRAGQ
CCCCCCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
KLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGE
CCCCCHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
LKYRMISKKENCASMALRVLRAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQR
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAGRGRASAHMRQARLDEHAREV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
ERIGAYFAELSAGRSGKHRDRADADLADAMKRCAPSARDDVAALTRKASVLVETLGRHLD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
APPPSDSSALRRLAAHAMIGRIEAFMAAAIAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINVGAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAE
CCCCHHHHHHCCCCCEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
QVRMENRRSLEVFVLALSKRYGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTG
HHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRHVYEHVSWWPNQRLGSKEHFD
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
RIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDALFFPRAGQ
CCCCCCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
KLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGE
CCCCCHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
LKYRMISKKENCASMALRVLRAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQR
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAGRGRASAHMRQARLDEHAREV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
ERIGAYFAELSAGRSGKHRDRADADLADAMKRCAPSARDDVAALTRKASVLVETLGRHLD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
APPPSDSSALRRLAAHAMIGRIEAFMAAAIAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA