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The map label for this gene is wecC [H]

Identifier: 126209015

GI number: 126209015

Start: 1773249

End: 1774520

Strand: Reverse

Name: wecC [H]

Synonym: APL_1551

Alternate gene names: 126209015

Gene position: 1774520-1773249 (Counterclockwise)

Preceding gene: 126209016

Following gene: 126209014

Centisome position: 78.02

GC content: 45.44

Gene sequence:

>1272_bases
ATGAATACGTTTAATCGAATTGCGATTATCGGACTGGGTTATATCGGGCTGCCGGCAGCGGTTGCTTTCGCCAGATGCGG
TAAGTCCGTTTTGGGTGTGGATATTAATCCCGATGTCGTTACAAAAATTAATCAAGGTCGGATTCATTTTGTTGAGCCGC
AGCTTGAAGAGGCGGTTAAACAAGCGGTCGAAAACGGCTTACTTTTTGCAACGCAGATTCCCGATCCTGCCGATGTATTT
GTGATCGCCGTGCCAACGCCTCTCACATATAACCACCAGCCTGATCTTCAGTATATTAAGCAAGCAGTGAAAGCAATCTC
TCCCTATTTAGTCAAAGGAAATTTGATTGTATTGGAATCGACTTCTCCGGTTGGGACAACAGAAAAATTGGCAAAATGGT
TGCAAAAACTTCGTCCTGATCTGAGTTTTCCGACTCAAGGTAACGACAATGCTGATATTTATATTGCTTATTGTCCGGAA
CGCGTGCTACCGGGCAGAGTGATGATTGAATTGTTTGAAAATGATCGGGTTATCGGCGGACTGACTGCCGAATCAACCCG
ACAAGCGGTCGATTTATACCGAATTTTTGTCAAAGGCGAGTGTATCGCCACCGATGCACGCACGGCGGAAATGTGCAAAT
TAACCGAGAATAGCTTCCGTGACGTGAATCTGGCGTTTGCCAACGAATTATCAATGATTTGCGATAAACTCAACATAAAT
GTATGGGAGCTGATCCGATTGGCGAATCGTCATCCGCGTGTAAATATTCTGCAACCGGGAGCTGGTGTCGGCGGACATTG
TATTGCGGTCGATCCGTGGTTTATTGCGGCACAAACGCCAGACCAATCCCGTTTAATTCGTACCGCACGAGAAGTAAACG
ACAGTAAGCCGCAATGGGTGATAGAGAAAGTGAAACAGGCATTAGCCGATTGTGTGAATCGCCGAAATTGTTTAGCCGGT
GATGTGACAATCGCTTGTTTAGGGCTAAGCTTTAAAGCGGATATTGATGATTTAAGAGGCAGTCCGGCATTGGCAATTAC
CCAATATCTTGCCGATTGGCATAGAGGGGTGGTGTTAGCGGTGGAACCGCATATTAATGCATTGCCACCATCGTTGAGAG
GTAAAGTCGAGCTGGTCGGTTTTGAACAGGCGATTAAGAAAGCGGATATTTTACTGTTATTAGTTGATCATACCGCATTT
AAAAACCTATCGCCCGACACGATGAGCGTACCGTGGTTAATTGATACGAAAGGGATATGGAGTCAATTATAA

Upstream 100 bases:

>100_bases
ACTTAAACAAATATTGAATTAGTCGGCAGGCTTTGTTCTTGGAAAAGACAAAGCCTGTTTTTTGTTACGGACGAACTTAA
AGCCAAACGAGAAATATCAT

Downstream 100 bases:

>100_bases
TGCAATGTTTTACCCCGGATCCGTGGCTGTCGGATTTCTTCGCCCGTCCGATTATACAAGCGAAGGTCACTGCTCAAGAT
TATCCAAAAATTCAGCAGCT

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNTFNRIAIIGLGYIGLPAAVAFARCGKSVLGVDINPDVVTKINQGRIHFVEPQLEEAVKQAVENGLLFATQIPDPADVF
VIAVPTPLTYNHQPDLQYIKQAVKAISPYLVKGNLIVLESTSPVGTTEKLAKWLQKLRPDLSFPTQGNDNADIYIAYCPE
RVLPGRVMIELFENDRVIGGLTAESTRQAVDLYRIFVKGECIATDARTAEMCKLTENSFRDVNLAFANELSMICDKLNIN
VWELIRLANRHPRVNILQPGAGVGGHCIAVDPWFIAAQTPDQSRLIRTAREVNDSKPQWVIEKVKQALADCVNRRNCLAG
DVTIACLGLSFKADIDDLRGSPALAITQYLADWHRGVVLAVEPHINALPPSLRGKVELVGFEQAIKKADILLLLVDHTAF
KNLSPDTMSVPWLIDTKGIWSQL

Sequences:

>Translated_423_residues
MNTFNRIAIIGLGYIGLPAAVAFARCGKSVLGVDINPDVVTKINQGRIHFVEPQLEEAVKQAVENGLLFATQIPDPADVF
VIAVPTPLTYNHQPDLQYIKQAVKAISPYLVKGNLIVLESTSPVGTTEKLAKWLQKLRPDLSFPTQGNDNADIYIAYCPE
RVLPGRVMIELFENDRVIGGLTAESTRQAVDLYRIFVKGECIATDARTAEMCKLTENSFRDVNLAFANELSMICDKLNIN
VWELIRLANRHPRVNILQPGAGVGGHCIAVDPWFIAAQTPDQSRLIRTAREVNDSKPQWVIEKVKQALADCVNRRNCLAG
DVTIACLGLSFKADIDDLRGSPALAITQYLADWHRGVVLAVEPHINALPPSLRGKVELVGFEQAIKKADILLLLVDHTAF
KNLSPDTMSVPWLIDTKGIWSQL
>Mature_423_residues
MNTFNRIAIIGLGYIGLPAAVAFARCGKSVLGVDINPDVVTKINQGRIHFVEPQLEEAVKQAVENGLLFATQIPDPADVF
VIAVPTPLTYNHQPDLQYIKQAVKAISPYLVKGNLIVLESTSPVGTTEKLAKWLQKLRPDLSFPTQGNDNADIYIAYCPE
RVLPGRVMIELFENDRVIGGLTAESTRQAVDLYRIFVKGECIATDARTAEMCKLTENSFRDVNLAFANELSMICDKLNIN
VWELIRLANRHPRVNILQPGAGVGGHCIAVDPWFIAAQTPDQSRLIRTAREVNDSKPQWVIEKVKQALADCVNRRNCLAG
DVTIACLGLSFKADIDDLRGSPALAITQYLADWHRGVVLAVEPHINALPPSLRGKVELVGFEQAIKKADILLLLVDHTAF
KNLSPDTMSVPWLIDTKGIWSQL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=376, Percent_Identity=27.1276595744681, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI296040438, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI48994968, Length=418, Percent_Identity=59.5693779904306, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788340, Length=281, Percent_Identity=26.6903914590747, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=373, Percent_Identity=25.7372654155496, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136908, Length=369, Percent_Identity=26.0162601626016, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46644; Mature: 46644

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFNRIAIIGLGYIGLPAAVAFARCGKSVLGVDINPDVVTKINQGRIHFVEPQLEEAVK
CCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHEEECCCEEEEECHHHHHHHH
QAVENGLLFATQIPDPADVFVIAVPTPLTYNHQPDLQYIKQAVKAISPYLVKGNLIVLES
HHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEECCEEEEEC
TSPVGTTEKLAKWLQKLRPDLSFPTQGNDNADIYIAYCPERVLPGRVMIELFENDRVIGG
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEE
LTAESTRQAVDLYRIFVKGECIATDARTAEMCKLTENSFRDVNLAFANELSMICDKLNIN
CCHHHHHHHHHHHHEEEECCEEECCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCC
VWELIRLANRHPRVNILQPGAGVGGHCIAVDPWFIAAQTPDQSRLIRTAREVNDSKPQWV
HHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCHHHH
IEKVKQALADCVNRRNCLAGDVTIACLGLSFKADIDDLRGSPALAITQYLADWHRGVVLA
HHHHHHHHHHHHHCCCCCCCCEEEEEEECEEECCHHHHCCCCHHHHHHHHHHHHCCEEEE
VEPHINALPPSLRGKVELVGFEQAIKKADILLLLVDHTAFKNLSPDTMSVPWLIDTKGIW
ECCCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCHHHCCCCCCCEECCEEEECCCHH
SQL
HCC
>Mature Secondary Structure
MNTFNRIAIIGLGYIGLPAAVAFARCGKSVLGVDINPDVVTKINQGRIHFVEPQLEEAVK
CCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHEEECCCEEEEECHHHHHHHH
QAVENGLLFATQIPDPADVFVIAVPTPLTYNHQPDLQYIKQAVKAISPYLVKGNLIVLES
HHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEECCEEEEEC
TSPVGTTEKLAKWLQKLRPDLSFPTQGNDNADIYIAYCPERVLPGRVMIELFENDRVIGG
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEE
LTAESTRQAVDLYRIFVKGECIATDARTAEMCKLTENSFRDVNLAFANELSMICDKLNIN
CCHHHHHHHHHHHHEEEECCEEECCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCC
VWELIRLANRHPRVNILQPGAGVGGHCIAVDPWFIAAQTPDQSRLIRTAREVNDSKPQWV
HHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCHHHH
IEKVKQALADCVNRRNCLAGDVTIACLGLSFKADIDDLRGSPALAITQYLADWHRGVVLA
HHHHHHHHHHHHHCCCCCCCCEEEEEEECEEECCHHHHCCCCHHHHHHHHHHHHCCEEEE
VEPHINALPPSLRGKVELVGFEQAIKKADILLLLVDHTAFKNLSPDTMSVPWLIDTKGIW
ECCCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEECCHHHCCCCCCCEECCEEEECCCHH
SQL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]