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The map label for this gene is wecB [H]

Identifier: 126209016

GI number: 126209016

Start: 1774599

End: 1775678

Strand: Reverse

Name: wecB [H]

Synonym: APL_1552

Alternate gene names: 126209016

Gene position: 1775678-1774599 (Counterclockwise)

Preceding gene: 126209017

Following gene: 126209015

Centisome position: 78.07

GC content: 46.39

Gene sequence:

>1080_bases
ATGGCTCCGCTGGCAAAAATGTTGGCGGAGGATGCGAGTTTTGAGGCAAAGGTCTGCGTAACCGGTCAGCATCGCGAGAT
GCTGGATCAAGTTTTGAACCTTTTCGAAATTCGGCCCGATTTTGATTTAAATATTATGCAAGTCGGGCAAGATCTAACCG
ACATCAGCGTACGAATTTTGCAATCGCTGAAAGATCTGTTTGCACGCTATCGTCCTGATATGGTATTGGTACACGGCGAT
ACCACTACTACTTTTGCCGCCGCACTCGCCTGCTATTATCATCAAATTCCGGTCGGACATATCGAAGCGGGCTTACGCAG
CGGCGATCGTTATGCGCCGTTTCCGGAAGAAGGTAATCGTTGCCTGACCGGCGTATTAGCCGACTATCACTTCGCACCGA
CCGAGCAAGCACGTCTAAATTTATTACAAGAACATAAAGCGCCCGATAAGATTTGGGTAACCGGCAATACGGTGCTTGAT
GCGTTACATTGCGTATCCTCCCGAATCCGACGAGATAAAAGTTTGGTTAAAAACTTGAATCGACATTATCAATTTTTAGA
CGAGCGGAAAAAACTCATTTTGGTTACCGGACACCGCCGAGAAAGTTTCGGCGCAGGCTTAGAACATATTTGCGAAGCGT
TGGTCACGCTTGCCAAACGGCATACCGATGTGCAGATTGTTTATCCGGTACATCTTAATCCTTGCGTACGCGAACCGGTC
AGCCGTTTACTTAGCGGAGTGGAAAATATCTTCTTAATCGAGCCGCAAGAGTATTTGTCCTTCGTCTATTTAATGGAACG
TGCTTATTTGATTTTGACCGATTCCGGCGGTATTCAAGAAGAAGCTCCCGCATTAAATAAACCGGTGTTGGTAATGCGTA
ACGCAACCGAACGTCCGGAAGCGGTTGCGGCGGGAACGGTTCGTCTGGTTGGAACCGAAGCTAAAAGCATTGTACAAGAG
GTGAGCTTGCTTTTAACCGATAAGCGGATTTATCGAACGATGGCGCAAGCAAAGAATCCTTATGCAAAGGAGAATGCTTG
CCGATATATTATTGACGTACTTAAACAAATATTGAATTAG

Upstream 100 bases:

>100_bases
GTCATTGTTTCAACAATGGGATTATTACGAAAAAAACCAGCAGATGCCGAACAAAATTAAAATCCTCAGCGTATTCGGTA
CGCGACCGGAAGCGATCAAG

Downstream 100 bases:

>100_bases
TCGGCAGGCTTTGTTCTTGGAAAAGACAAAGCCTGTTTTTTGTTACGGACGAACTTAAAGCCAAACGAGAAATATCATAT
GAATACGTTTAATCGAATTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAPLAKMLAEDASFEAKVCVTGQHREMLDQVLNLFEIRPDFDLNIMQVGQDLTDISVRILQSLKDLFARYRPDMVLVHGD
TTTTFAAALACYYHQIPVGHIEAGLRSGDRYAPFPEEGNRCLTGVLADYHFAPTEQARLNLLQEHKAPDKIWVTGNTVLD
ALHCVSSRIRRDKSLVKNLNRHYQFLDERKKLILVTGHRRESFGAGLEHICEALVTLAKRHTDVQIVYPVHLNPCVREPV
SRLLSGVENIFLIEPQEYLSFVYLMERAYLILTDSGGIQEEAPALNKPVLVMRNATERPEAVAAGTVRLVGTEAKSIVQE
VSLLLTDKRIYRTMAQAKNPYAKENACRYIIDVLKQILN

Sequences:

>Translated_359_residues
MAPLAKMLAEDASFEAKVCVTGQHREMLDQVLNLFEIRPDFDLNIMQVGQDLTDISVRILQSLKDLFARYRPDMVLVHGD
TTTTFAAALACYYHQIPVGHIEAGLRSGDRYAPFPEEGNRCLTGVLADYHFAPTEQARLNLLQEHKAPDKIWVTGNTVLD
ALHCVSSRIRRDKSLVKNLNRHYQFLDERKKLILVTGHRRESFGAGLEHICEALVTLAKRHTDVQIVYPVHLNPCVREPV
SRLLSGVENIFLIEPQEYLSFVYLMERAYLILTDSGGIQEEAPALNKPVLVMRNATERPEAVAAGTVRLVGTEAKSIVQE
VSLLLTDKRIYRTMAQAKNPYAKENACRYIIDVLKQILN
>Mature_358_residues
APLAKMLAEDASFEAKVCVTGQHREMLDQVLNLFEIRPDFDLNIMQVGQDLTDISVRILQSLKDLFARYRPDMVLVHGDT
TTTFAAALACYYHQIPVGHIEAGLRSGDRYAPFPEEGNRCLTGVLADYHFAPTEQARLNLLQEHKAPDKIWVTGNTVLDA
LHCVSSRIRRDKSLVKNLNRHYQFLDERKKLILVTGHRRESFGAGLEHICEALVTLAKRHTDVQIVYPVHLNPCVREPVS
RLLSGVENIFLIEPQEYLSFVYLMERAYLILTDSGGIQEEAPALNKPVLVMRNATERPEAVAAGTVRLVGTEAKSIVQEV
SLLLTDKRIYRTMAQAKNPYAKENACRYIIDVLKQILN

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=356, Percent_Identity=62.9213483146067, Blast_Score=451, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 40562; Mature: 40431

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLAKMLAEDASFEAKVCVTGQHREMLDQVLNLFEIRPDFDLNIMQVGQDLTDISVRIL
CCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHH
QSLKDLFARYRPDMVLVHGDTTTTFAAALACYYHQIPVGHIEAGLRSGDRYAPFPEEGNR
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCH
CLTGVLADYHFAPTEQARLNLLQEHKAPDKIWVTGNTVLDALHCVSSRIRRDKSLVKNLN
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
RHYQFLDERKKLILVTGHRRESFGAGLEHICEALVTLAKRHTDVQIVYPVHLNPCVREPV
HHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHH
SRLLSGVENIFLIEPQEYLSFVYLMERAYLILTDSGGIQEEAPALNKPVLVMRNATERPE
HHHHHCCCCEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCC
AVAAGTVRLVGTEAKSIVQEVSLLLTDKRIYRTMAQAKNPYAKENACRYIIDVLKQILN
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
APLAKMLAEDASFEAKVCVTGQHREMLDQVLNLFEIRPDFDLNIMQVGQDLTDISVRIL
CHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHH
QSLKDLFARYRPDMVLVHGDTTTTFAAALACYYHQIPVGHIEAGLRSGDRYAPFPEEGNR
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCH
CLTGVLADYHFAPTEQARLNLLQEHKAPDKIWVTGNTVLDALHCVSSRIRRDKSLVKNLN
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
RHYQFLDERKKLILVTGHRRESFGAGLEHICEALVTLAKRHTDVQIVYPVHLNPCVREPV
HHHHHHHCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHH
SRLLSGVENIFLIEPQEYLSFVYLMERAYLILTDSGGIQEEAPALNKPVLVMRNATERPE
HHHHHCCCCEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCC
AVAAGTVRLVGTEAKSIVQEVSLLLTDKRIYRTMAQAKNPYAKENACRYIIDVLKQILN
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]