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The map label for this gene is dsbC [H]

Identifier: 126207942

GI number: 126207942

Start: 529475

End: 530170

Strand: Direct

Name: dsbC [H]

Synonym: APL_0458

Alternate gene names: 126207942

Gene position: 529475-530170 (Clockwise)

Preceding gene: 126207941

Following gene: 126207943

Centisome position: 23.28

GC content: 39.66

Gene sequence:

>696_bases
ATGAAAAAAAATGTAACGGCATTATTTTCCGTTTCTTTAATGGGCTTATGCGTATCTCCCGTGATGGCTGATGATATGAG
CTTGGTAAAAACGTTAGAAGGGATGGGGGCAACGAATGTAAAAATCAGTGATTCGGCGCTGCCCGGTTTTAGAACCGCCG
TTTCAAGTGAAGGCGTGGTACAAATCAGTGAAAACGGACGTTTTGTGATCCAAGGGCAAATTTTTGAACTGAAAAACGGC
AAAGCGGTTAATATTACTAACAAATCATTGTTAGCGGATTTAAATGCATTGGAAAAAGAGATGATTATTTATCCGGCAAA
AAATGAGAAGCACGTAGTTACCGTATTTATGGATATTACCTGTCATTATTGCCATTTAATGTTCCAACGTATTAAAGAGT
ATAACGATTTGGGTATTACCATTCGTTTCCTCGCTTTCCCTCGCGGCGGAATGAATACACAAACCGCAAAACAAATGGAA
GCGATTTGGACATCGGCGGATAAAGTGAAAGCATTAACCGATGCGGAAAACGGTACTTTACCGAAAGAAGTAAAAACACC
GAATATCGTGAAAAAACACTATGAACTCGGCATTAAATTCGGCGTAACAGGTACCCCGAATATGGTCGATAGCACCGGTC
AATTGATAGCCGGTTATGTAGAACCTAAAGAATTACTTAAAATGTTAAGCGAATAG

Upstream 100 bases:

>100_bases
TTCAAATTCGGGTATGGCGGATAAAGAACGTAAGAAGTTCTTAACGCGTGCTAAATATGTTGAAGCAAAATTAAAATTTT
AATTTATAGGATATTTAATC

Downstream 100 bases:

>100_bases
CATTAAGTCCTTGAATACAAGCGGTCTGATTTTGTAAAATTTTTGCAAAATGATACCGCTTGTTTTATTTATAACGAAAA
GAAGAAAAATAGTGCAAAAG

Product: thiol:disulfide interchange protein DsbC precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKKNVTALFSVSLMGLCVSPVMADDMSLVKTLEGMGATNVKISDSALPGFRTAVSSEGVVQISENGRFVIQGQIFELKNG
KAVNITNKSLLADLNALEKEMIIYPAKNEKHVVTVFMDITCHYCHLMFQRIKEYNDLGITIRFLAFPRGGMNTQTAKQME
AIWTSADKVKALTDAENGTLPKEVKTPNIVKKHYELGIKFGVTGTPNMVDSTGQLIAGYVEPKELLKMLSE

Sequences:

>Translated_231_residues
MKKNVTALFSVSLMGLCVSPVMADDMSLVKTLEGMGATNVKISDSALPGFRTAVSSEGVVQISENGRFVIQGQIFELKNG
KAVNITNKSLLADLNALEKEMIIYPAKNEKHVVTVFMDITCHYCHLMFQRIKEYNDLGITIRFLAFPRGGMNTQTAKQME
AIWTSADKVKALTDAENGTLPKEVKTPNIVKKHYELGIKFGVTGTPNMVDSTGQLIAGYVEPKELLKMLSE
>Mature_231_residues
MKKNVTALFSVSLMGLCVSPVMADDMSLVKTLEGMGATNVKISDSALPGFRTAVSSEGVVQISENGRFVIQGQIFELKNG
KAVNITNKSLLADLNALEKEMIIYPAKNEKHVVTVFMDITCHYCHLMFQRIKEYNDLGITIRFLAFPRGGMNTQTAKQME
AIWTSADKVKALTDAENGTLPKEVKTPNIVKKHYELGIKFGVTGTPNMVDSTGQLIAGYVEPKELLKMLSE

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=209, Percent_Identity=44.4976076555024, Blast_Score=201, Evalue=3e-53,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 25394; Mature: 25394

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNVTALFSVSLMGLCVSPVMADDMSLVKTLEGMGATNVKISDSALPGFRTAVSSEGVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCEE
QISENGRFVIQGQIFELKNGKAVNITNKSLLADLNALEKEMIIYPAKNEKHVVTVFMDIT
EECCCCEEEEEEEEEEECCCCEEEECCHHHHHHHHHHCCEEEEEECCCCCEEEEEEEEHH
CHYCHLMFQRIKEYNDLGITIRFLAFPRGGMNTQTAKQMEAIWTSADKVKALTDAENGTL
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHECCCCCCCC
PKEVKTPNIVKKHYELGIKFGVTGTPNMVDSTGQLIAGYVEPKELLKMLSE
CCCCCCCHHHHHHHHCEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MKKNVTALFSVSLMGLCVSPVMADDMSLVKTLEGMGATNVKISDSALPGFRTAVSSEGVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHCCCCCEE
QISENGRFVIQGQIFELKNGKAVNITNKSLLADLNALEKEMIIYPAKNEKHVVTVFMDIT
EECCCCEEEEEEEEEEECCCCEEEECCHHHHHHHHHHCCEEEEEECCCCCEEEEEEEEHH
CHYCHLMFQRIKEYNDLGITIRFLAFPRGGMNTQTAKQMEAIWTSADKVKALTDAENGTL
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHECCCCCCCC
PKEVKTPNIVKKHYELGIKFGVTGTPNMVDSTGQLIAGYVEPKELLKMLSE
CCCCCCCHHHHHHHHCEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]