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The map label for this gene is ubiH [H]

Identifier: 126207813

GI number: 126207813

Start: 366103

End: 367302

Strand: Direct

Name: ubiH [H]

Synonym: APL_0329

Alternate gene names: 126207813

Gene position: 366103-367302 (Clockwise)

Preceding gene: 126207812

Following gene: 126207830

Centisome position: 16.1

GC content: 44.17

Gene sequence:

>1200_bases
ATGGCAGAGCAATTTGATGTGGTTATTGTTGGCGGTGCGGTGACCGGTTCGGTACTGGCATTGGCGTTAAGTAGCTTGTC
GCAGCATAAAATGCGGATTGCGATCGTTGAAAAACAGTTGCCTGATTATGCGCAACAAGGCGGTTTTGATGCACGTAGTA
TTGCGTTGGCACAAGGCAGTTTGCAAAAATTTGCGCAAATTCGACCGCTTGCCGGCAGCTCACTTGCCGAACAAATTCAG
CAAATTGCAACGCCAATCCAACAGATTCAGGTGTCAGACCTCGGTCATTTCGGTAAAACGACATTAAAAGCAAGTGAACT
GAATTTAGCACAATTAGGTGTCGTGGTGGAGCTGGCAAAATTAGGCAAAAATTTGACCGCTTGTATTGAGCAGCAGCCGA
ATATCCATTGGTTTTGTCCGAATCAAATAGTTCATTTCGAACGTTTACAAACTGAAGTTTTGCTTAGATTGCAAAACGGT
GAGCGGCTTCGCACGCAATTAATGGTAGCGGCAGATGGGATCCAATCCCAAATTGCTCTGCAGTGTGGCGTTGAAACTGA
GCTATTAAAGGATTATCAACAATCGGCTTTGATTGCCAATGTTGAAATCAGTGAACCGTATCAAGGGCAAGCTTTTGAGC
GTTTTACGACGCAAGGGCCGTTAGCCTTATTGCCGTTAAGTGATAATCGAATGTCGTTAGTTTGGTGTGTGAAACAAGCG
GAAGATTTGCTGAGCCTTACCGATGAAGATTTTCTTTCGCAATTACAGCTGCAATTCGGTTGGACATTAGGAAAGTTTGA
GCGAGTCAGCAAGCGGTTTGTTTATCTGCTCACTTCGCAAAAAGCGCAATCGCATATTCATCATCGCTTGGCAATTGTGG
GGAATGCCGCACAGTTATTGCACCCGGTCGCAGGGCAGGGCTTTAATCTTGGAATGCGAGATCTGTTTACTCTTGCACAG
CTGTTAGCCAAAGCCTTTGCACAAGGAAAAGATTTAGGTGCGTTCGCATTGCTTAATCAATTCGAGCAAGCAAGAAAGCA
AGATCAAGCGCAGATTATTTCTCTAACAAGCGGTTTAATTTCACTGTTTTCTTGCGATTTCTTACCGCTACAAGCGGTCA
GAAATTTAGGCTTATTTGCGATTTCGCATAGCAAATTGCTTCGAGAAAATATTGCGAATAAGGCTTTAGGTTGGCAATAA

Upstream 100 bases:

>100_bases
ATGTGAGCGAAATCCGTTAGTCACTCAATCACTCGAAGATTATTTGAGCGGTGAGAGCTATACGCTTGATGTATTACGTG
TATTTGAATAAGAGGTGGAA

Downstream 100 bases:

>100_bases
AATTAAAAGGACGCACTGGGCGTCCTTTTTTATAGTTGATATTTTTTCATTAATTTTAATTTTTCATGCGAGATTTCATT
ACCTAGTTGAGTAATTATTT

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAEQFDVVIVGGAVTGSVLALALSSLSQHKMRIAIVEKQLPDYAQQGGFDARSIALAQGSLQKFAQIRPLAGSSLAEQIQ
QIATPIQQIQVSDLGHFGKTTLKASELNLAQLGVVVELAKLGKNLTACIEQQPNIHWFCPNQIVHFERLQTEVLLRLQNG
ERLRTQLMVAADGIQSQIALQCGVETELLKDYQQSALIANVEISEPYQGQAFERFTTQGPLALLPLSDNRMSLVWCVKQA
EDLLSLTDEDFLSQLQLQFGWTLGKFERVSKRFVYLLTSQKAQSHIHHRLAIVGNAAQLLHPVAGQGFNLGMRDLFTLAQ
LLAKAFAQGKDLGAFALLNQFEQARKQDQAQIISLTSGLISLFSCDFLPLQAVRNLGLFAISHSKLLRENIANKALGWQ

Sequences:

>Translated_399_residues
MAEQFDVVIVGGAVTGSVLALALSSLSQHKMRIAIVEKQLPDYAQQGGFDARSIALAQGSLQKFAQIRPLAGSSLAEQIQ
QIATPIQQIQVSDLGHFGKTTLKASELNLAQLGVVVELAKLGKNLTACIEQQPNIHWFCPNQIVHFERLQTEVLLRLQNG
ERLRTQLMVAADGIQSQIALQCGVETELLKDYQQSALIANVEISEPYQGQAFERFTTQGPLALLPLSDNRMSLVWCVKQA
EDLLSLTDEDFLSQLQLQFGWTLGKFERVSKRFVYLLTSQKAQSHIHHRLAIVGNAAQLLHPVAGQGFNLGMRDLFTLAQ
LLAKAFAQGKDLGAFALLNQFEQARKQDQAQIISLTSGLISLFSCDFLPLQAVRNLGLFAISHSKLLRENIANKALGWQ
>Mature_398_residues
AEQFDVVIVGGAVTGSVLALALSSLSQHKMRIAIVEKQLPDYAQQGGFDARSIALAQGSLQKFAQIRPLAGSSLAEQIQQ
IATPIQQIQVSDLGHFGKTTLKASELNLAQLGVVVELAKLGKNLTACIEQQPNIHWFCPNQIVHFERLQTEVLLRLQNGE
RLRTQLMVAADGIQSQIALQCGVETELLKDYQQSALIANVEISEPYQGQAFERFTTQGPLALLPLSDNRMSLVWCVKQAE
DLLSLTDEDFLSQLQLQFGWTLGKFERVSKRFVYLLTSQKAQSHIHHRLAIVGNAAQLLHPVAGQGFNLGMRDLFTLAQL
LAKAFAQGKDLGAFALLNQFEQARKQDQAQIISLTSGLISLFSCDFLPLQAVRNLGLFAISHSKLLRENIANKALGWQ

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=332, Percent_Identity=29.5180722891566, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI32967307, Length=332, Percent_Identity=29.5180722891566, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789274, Length=396, Percent_Identity=42.4242424242424, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI1789273, Length=380, Percent_Identity=28.6842105263158, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1786883, Length=395, Percent_Identity=28.6075949367089, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25146631, Length=428, Percent_Identity=23.5981308411215, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321694, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19920760, Length=425, Percent_Identity=26.1176470588235, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 43962; Mature: 43831

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQFDVVIVGGAVTGSVLALALSSLSQHKMRIAIVEKQLPDYAQQGGFDARSIALAQGS
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCCHHHHCCCCHHHHHHHHHH
LQKFAQIRPLAGSSLAEQIQQIATPIQQIQVSDLGHFGKTTLKASELNLAQLGVVVELAK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHHHHHHHHHH
LGKNLTACIEQQPNIHWFCPNQIVHFERLQTEVLLRLQNGERLRTQLMVAADGIQSQIAL
HCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
QCGVETELLKDYQQSALIANVEISEPYQGQAFERFTTQGPLALLPLSDNRMSLVWCVKQA
HCCCCHHHHHHHHHHHEEEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCEEEEHHHHHH
EDLLSLTDEDFLSQLQLQFGWTLGKFERVSKRFVYLLTSQKAQSHIHHRLAIVGNAAQLL
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCHHHHH
HPVAGQGFNLGMRDLFTLAQLLAKAFAQGKDLGAFALLNQFEQARKQDQAQIISLTSGLI
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFSCDFLPLQAVRNLGLFAISHSKLLRENIANKALGWQ
HHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEQFDVVIVGGAVTGSVLALALSSLSQHKMRIAIVEKQLPDYAQQGGFDARSIALAQGS
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCCHHHHCCCCHHHHHHHHHH
LQKFAQIRPLAGSSLAEQIQQIATPIQQIQVSDLGHFGKTTLKASELNLAQLGVVVELAK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCHHHHHHHHHHHH
LGKNLTACIEQQPNIHWFCPNQIVHFERLQTEVLLRLQNGERLRTQLMVAADGIQSQIAL
HCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
QCGVETELLKDYQQSALIANVEISEPYQGQAFERFTTQGPLALLPLSDNRMSLVWCVKQA
HCCCCHHHHHHHHHHHEEEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCEEEEHHHHHH
EDLLSLTDEDFLSQLQLQFGWTLGKFERVSKRFVYLLTSQKAQSHIHHRLAIVGNAAQLL
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCHHHHH
HPVAGQGFNLGMRDLFTLAQLLAKAFAQGKDLGAFALLNQFEQARKQDQAQIISLTSGLI
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLFSCDFLPLQAVRNLGLFAISHSKLLRENIANKALGWQ
HHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]