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The map label for this gene is moeB [H]

Identifier: 126207795

GI number: 126207795

Start: 345389

End: 346135

Strand: Direct

Name: moeB [H]

Synonym: APL_0311

Alternate gene names: 126207795

Gene position: 345389-346135 (Clockwise)

Preceding gene: 126207794

Following gene: 126207797

Centisome position: 15.19

GC content: 42.7

Gene sequence:

>747_bases
ATGGAACTTAGCGATCAGGAAATGTTGCGCTATAACCGTCAAATTATTTTAAAAAGTGTTGATTTTGACGGGCAAGAAAA
ACTAAAAGCCAGCCGAGTATTAATTGTCGGTTTGGGCGGTTTGGGGTGTAGTGCGGCGCAATATTTAGCTTCAGCCGGTG
TCGGCCATTTGATCTTGGTTGATTTTGATGAAGTGTCGTTGTCAAACTTGCAGCGCCAAATTTTGCATACGGATGCGAAT
ATCGGTCAGCTGAAAGTAGAGTCGGCAAAGGTGCGTTTAAGCCAAATTAATCCGCATATTCAGCTTGAAGCGATTAATAA
ACAATGTAGCGATGCGGAATTTGCCGAGCTGATTGAGCGAGTGGATTTAGTCGTGGATTGCACTGATAACGTCACGGTTA
GAAATCAGCTGAATTTGCAATGTTTTGCGCAAAAACGACCGCTTGTTTCCGGTTCGGCGATTCGCTTTGAGGGGCAAATT
TCAGTATTTACCTATGCTGAAAATGAGCCTTGTTATAACTGTTTAAGCCGATTATTCGGTGACGGCACTTTAAGCTGTGT
GGAAGCCGGTGTAATTGCGCCGATTGTCGGCGTAGTCGGCAGTTTACAAGCGTTGGAAGCGATTAAATTATTGCTGAATA
TCGGCAAAAGCCTTTCCGGAAAACTGTTGATGATTGACGGTTTATATTTTTCAGTGAGAGAAATGAATCTCCCGAAACTT
CAGGATTGTGAAATTTGTTGTCAATAA

Upstream 100 bases:

>100_bases
CAACTGTTTTATTGTGTTGGAAGCGGAACGAGGCAATGTGGATGCCGGTGAAAAAGTGACGATTCAGCCGTTTAACAGTT
TATTGAGATAGTGAGTGAAT

Downstream 100 bases:

>100_bases
AAAGTTAAAGTTCAAGAATTGCAAAGAATTGACAAGTTAGGTTATAGCATTTGACGCTAAAACGGTTTAGCGATATTATT
TTTTCGTATTGTTCCTCCTT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MELSDQEMLRYNRQIILKSVDFDGQEKLKASRVLIVGLGGLGCSAAQYLASAGVGHLILVDFDEVSLSNLQRQILHTDAN
IGQLKVESAKVRLSQINPHIQLEAINKQCSDAEFAELIERVDLVVDCTDNVTVRNQLNLQCFAQKRPLVSGSAIRFEGQI
SVFTYAENEPCYNCLSRLFGDGTLSCVEAGVIAPIVGVVGSLQALEAIKLLLNIGKSLSGKLLMIDGLYFSVREMNLPKL
QDCEICCQ

Sequences:

>Translated_248_residues
MELSDQEMLRYNRQIILKSVDFDGQEKLKASRVLIVGLGGLGCSAAQYLASAGVGHLILVDFDEVSLSNLQRQILHTDAN
IGQLKVESAKVRLSQINPHIQLEAINKQCSDAEFAELIERVDLVVDCTDNVTVRNQLNLQCFAQKRPLVSGSAIRFEGQI
SVFTYAENEPCYNCLSRLFGDGTLSCVEAGVIAPIVGVVGSLQALEAIKLLLNIGKSLSGKLLMIDGLYFSVREMNLPKL
QDCEICCQ
>Mature_248_residues
MELSDQEMLRYNRQIILKSVDFDGQEKLKASRVLIVGLGGLGCSAAQYLASAGVGHLILVDFDEVSLSNLQRQILHTDAN
IGQLKVESAKVRLSQINPHIQLEAINKQCSDAEFAELIERVDLVVDCTDNVTVRNQLNLQCFAQKRPLVSGSAIRFEGQI
SVFTYAENEPCYNCLSRLFGDGTLSCVEAGVIAPIVGVVGSLQALEAIKLLLNIGKSLSGKLLMIDGLYFSVREMNLPKL
QDCEICCQ

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=228, Percent_Identity=45.6140350877193, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=30.718954248366, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI23510338, Length=166, Percent_Identity=28.9156626506024, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI23510340, Length=166, Percent_Identity=28.9156626506024, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI150417996, Length=147, Percent_Identity=29.2517006802721, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=29.5180722891566, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=67.6113360323887, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI87082356, Length=244, Percent_Identity=45.0819672131148, Blast_Score=194, Evalue=3e-51,
Organism=Escherichia coli, GI1789177, Length=121, Percent_Identity=32.2314049586777, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=247, Percent_Identity=38.8663967611336, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI193203301, Length=154, Percent_Identity=30.5194805194805, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321903, Length=251, Percent_Identity=35.8565737051793, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=27.4390243902439, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325438, Length=124, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=43.9516129032258, Blast_Score=213, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24660640, Length=154, Percent_Identity=29.2207792207792, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641311, Length=232, Percent_Identity=30.6034482758621, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27177; Mature: 27177

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSDQEMLRYNRQIILKSVDFDGQEKLKASRVLIVGLGGLGCSAAQYLASAGVGHLILV
CCCCHHHHHHHCCEEEEEECCCCCHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEEEEE
DFDEVSLSNLQRQILHTDANIGQLKVESAKVRLSQINPHIQLEAINKQCSDAEFAELIER
ECCHHHHHHHHHHHHHCCCCCCEEEEHHHEEEHHHCCCCEEEEECCCCCCCCHHHHHHHH
VDLVVDCTDNVTVRNQLNLQCFAQKRPLVSGSAIRFEGQISVFTYAENEPCYNCLSRLFG
HCEEEECCCCEEEECCCCEEEEECCCCCCCCCEEEEECEEEEEEEECCCCHHHHHHHHHC
DGTLSCVEAGVIAPIVGVVGSLQALEAIKLLLNIGKSLSGKLLMIDGLYFSVREMNLPKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEEECCCCCCC
QDCEICCQ
CCCHHCCC
>Mature Secondary Structure
MELSDQEMLRYNRQIILKSVDFDGQEKLKASRVLIVGLGGLGCSAAQYLASAGVGHLILV
CCCCHHHHHHHCCEEEEEECCCCCHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEEEEE
DFDEVSLSNLQRQILHTDANIGQLKVESAKVRLSQINPHIQLEAINKQCSDAEFAELIER
ECCHHHHHHHHHHHHHCCCCCCEEEEHHHEEEHHHCCCCEEEEECCCCCCCCHHHHHHHH
VDLVVDCTDNVTVRNQLNLQCFAQKRPLVSGSAIRFEGQISVFTYAENEPCYNCLSRLFG
HCEEEECCCCEEEECCCCEEEEECCCCCCCCCEEEEECEEEEEEEECCCCHHHHHHHHHC
DGTLSCVEAGVIAPIVGVVGSLQALEAIKLLLNIGKSLSGKLLMIDGLYFSVREMNLPKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEEECCCCCCC
QDCEICCQ
CCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]