Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 126207794

GI number: 126207794

Start: 344138

End: 345379

Strand: Direct

Name: moeA [H]

Synonym: APL_0310

Alternate gene names: 126207794

Gene position: 344138-345379 (Clockwise)

Preceding gene: 126207792

Following gene: 126207795

Centisome position: 15.13

GC content: 45.33

Gene sequence:

>1242_bases
ATGGCATTACTTCCTTTATCCGAAGCGTTAGCCAATATGTTGGCACGCTTACCTTCCCCGACTAAAATCGAAAACTTACC
GCTTAATCAATGTGCCAATCGTATTTTGGCGGAAGATATTTTTTCTCCGATTAATGTGCCGAGTTTCGATAATTCGGCAA
TGGACGGCTATGCGTTTCGTTTAGCCGATCTGGTGCAATTCGAGCGTTTAATCGTTGCCGGTAAATCGTTTGCCGGTAAT
CCGTTTATCGGCGAAGTAAAAGCCGGCGAATGTATTCGCATTATGACCGGTGCGATGGTGCCGGCAGATTGTGATGTGGT
GGTAATGCAAGAAGAAGCGGAAGCGGAAACACTTGCAAGCGGTCAAATTTCAGTGAAATTTTGCAAAACGCCGAAACTCG
GACAAAACATTCGCCGAATCGGTGAAGATGTAAAACAAGGCGCATTGGTATTGGCGAAAGGCAGCTTATTAAATGTAACT
ACTTTGCCGTTATTAGCCTCGTTAGGCGTTGCACAAGTGCCGGTATTTAGCCGTTTAAAAGTCGCCATTCTTTCCACCGG
TGATGAACTGACTTCGGTTGGTCAGGCGCTCGAGCAAGGCAAAATTTATGATACCAACCGTTTTGCTGTGCGTTTAATGT
TAGAAAAACTCAATTGTGATATTTTGGATTTTGGTATTCTACCGGATGATCCGGCAGTGTTTGAACAAACATTCACTCAA
GCGCAACAGCAAGCGGACGTATTAATTACCAGCGGCGGAGTGTCGGTAGGAGAAGCGGATTTCACTAAAGAGGTGTTAGA
TAAACTGGGCGAAATCGGCTTTTGGAAAATTGCGATGAAACCGGGCAAACCGTTCGCTTTTGGGAAATTGCAACACGCGT
GGTTCTTCGGTTTACCGGGTAATCCGGTTTCCGCGTTAGTGACCTTTTACCAACTGGTGCAACCGGCATTAGCTAAATTA
GCCGGTGTGAATGCGGAGCGTATTGCAAATCTTACTCAAAATTTAACCGCTATTGCCGATACGAATTTGAAAAAAGCGGT
AGGTCGCCAAGATTTCCAACGTGGCTTCTATTATGTGAATGAGCAAGGCGAAGTCGCGGTACGTCCGGTCGGCTTGCAAG
GTTCTCATCTGTTTAGCGCATTTTATGAAAGCAACTGTTTTATTGTGTTGGAAGCGGAACGAGGCAATGTGGATGCCGGT
GAAAAAGTGACGATTCAGCCGTTTAACAGTTTATTGAGATAG

Upstream 100 bases:

>100_bases
TTTCTAAACTTAGAGAGCAATCGAAAGAACATTAGATATTTAAAAGGGCGTATTTACGCCCTTTATCGTTTTATACATTT
TAAGGTACTTATAAATAGTT

Downstream 100 bases:

>100_bases
TGAGTGAATATGGAACTTAGCGATCAGGAAATGTTGCGCTATAACCGTCAAATTATTTTAAAAAGTGTTGATTTTGACGG
GCAAGAAAAACTAAAAGCCA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MALLPLSEALANMLARLPSPTKIENLPLNQCANRILAEDIFSPINVPSFDNSAMDGYAFRLADLVQFERLIVAGKSFAGN
PFIGEVKAGECIRIMTGAMVPADCDVVVMQEEAEAETLASGQISVKFCKTPKLGQNIRRIGEDVKQGALVLAKGSLLNVT
TLPLLASLGVAQVPVFSRLKVAILSTGDELTSVGQALEQGKIYDTNRFAVRLMLEKLNCDILDFGILPDDPAVFEQTFTQ
AQQQADVLITSGGVSVGEADFTKEVLDKLGEIGFWKIAMKPGKPFAFGKLQHAWFFGLPGNPVSALVTFYQLVQPALAKL
AGVNAERIANLTQNLTAIADTNLKKAVGRQDFQRGFYYVNEQGEVAVRPVGLQGSHLFSAFYESNCFIVLEAERGNVDAG
EKVTIQPFNSLLR

Sequences:

>Translated_413_residues
MALLPLSEALANMLARLPSPTKIENLPLNQCANRILAEDIFSPINVPSFDNSAMDGYAFRLADLVQFERLIVAGKSFAGN
PFIGEVKAGECIRIMTGAMVPADCDVVVMQEEAEAETLASGQISVKFCKTPKLGQNIRRIGEDVKQGALVLAKGSLLNVT
TLPLLASLGVAQVPVFSRLKVAILSTGDELTSVGQALEQGKIYDTNRFAVRLMLEKLNCDILDFGILPDDPAVFEQTFTQ
AQQQADVLITSGGVSVGEADFTKEVLDKLGEIGFWKIAMKPGKPFAFGKLQHAWFFGLPGNPVSALVTFYQLVQPALAKL
AGVNAERIANLTQNLTAIADTNLKKAVGRQDFQRGFYYVNEQGEVAVRPVGLQGSHLFSAFYESNCFIVLEAERGNVDAG
EKVTIQPFNSLLR
>Mature_412_residues
ALLPLSEALANMLARLPSPTKIENLPLNQCANRILAEDIFSPINVPSFDNSAMDGYAFRLADLVQFERLIVAGKSFAGNP
FIGEVKAGECIRIMTGAMVPADCDVVVMQEEAEAETLASGQISVKFCKTPKLGQNIRRIGEDVKQGALVLAKGSLLNVTT
LPLLASLGVAQVPVFSRLKVAILSTGDELTSVGQALEQGKIYDTNRFAVRLMLEKLNCDILDFGILPDDPAVFEQTFTQA
QQQADVLITSGGVSVGEADFTKEVLDKLGEIGFWKIAMKPGKPFAFGKLQHAWFFGLPGNPVSALVTFYQLVQPALAKLA
GVNAERIANLTQNLTAIADTNLKKAVGRQDFQRGFYYVNEQGEVAVRPVGLQGSHLFSAFYESNCFIVLEAERGNVDAGE
KVTIQPFNSLLR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=367, Percent_Identity=34.8773841961853, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI10880983, Length=367, Percent_Identity=34.8773841961853, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787049, Length=411, Percent_Identity=56.4476885644769, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=28.735632183908, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=331, Percent_Identity=28.7009063444109, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136978, Length=408, Percent_Identity=31.8627450980392, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24638841, Length=408, Percent_Identity=31.8627450980392, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44731; Mature: 44600

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLPLSEALANMLARLPSPTKIENLPLNQCANRILAEDIFSPINVPSFDNSAMDGYAFR
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LADLVQFERLIVAGKSFAGNPFIGEVKAGECIRIMTGAMVPADCDVVVMQEEAEAETLAS
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEHHCCCCCCCCCEEEEECCCCHHHHCC
GQISVKFCKTPKLGQNIRRIGEDVKQGALVLAKGSLLNVTTLPLLASLGVAQVPVFSRLK
CCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHHCCHHHCCHHHHEE
VAILSTGDELTSVGQALEQGKIYDTNRFAVRLMLEKLNCDILDFGILPDDPAVFEQTFTQ
EEEEECCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
AQQQADVLITSGGVSVGEADFTKEVLDKLGEIGFWKIAMKPGKPFAFGKLQHAWFFGLPG
HHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCC
NPVSALVTFYQLVQPALAKLAGVNAERIANLTQNLTAIADTNLKKAVGRQDFQRGFYYVN
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCCCEEEC
EQGEVAVRPVGLQGSHLFSAFYESNCFIVLEAERGNVDAGEKVTIQPFNSLLR
CCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHCC
>Mature Secondary Structure 
ALLPLSEALANMLARLPSPTKIENLPLNQCANRILAEDIFSPINVPSFDNSAMDGYAFR
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LADLVQFERLIVAGKSFAGNPFIGEVKAGECIRIMTGAMVPADCDVVVMQEEAEAETLAS
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEHHCCCCCCCCCEEEEECCCCHHHHCC
GQISVKFCKTPKLGQNIRRIGEDVKQGALVLAKGSLLNVTTLPLLASLGVAQVPVFSRLK
CCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHHCCHHHCCHHHHEE
VAILSTGDELTSVGQALEQGKIYDTNRFAVRLMLEKLNCDILDFGILPDDPAVFEQTFTQ
EEEEECCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHH
AQQQADVLITSGGVSVGEADFTKEVLDKLGEIGFWKIAMKPGKPFAFGKLQHAWFFGLPG
HHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCC
NPVSALVTFYQLVQPALAKLAGVNAERIANLTQNLTAIADTNLKKAVGRQDFQRGFYYVN
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCCCEEEC
EQGEVAVRPVGLQGSHLFSAFYESNCFIVLEAERGNVDAGEKVTIQPFNSLLR
CCCCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]