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The map label for this gene is thrCA [H]

Identifier: 126207757

GI number: 126207757

Start: 297556

End: 298650

Strand: Direct

Name: thrCA [H]

Synonym: APL_0269

Alternate gene names: 126207757

Gene position: 297556-298650 (Clockwise)

Preceding gene: 126207756

Following gene: 126207758

Centisome position: 13.08

GC content: 40.46

Gene sequence:

>1095_bases
ATGAAATTTATCTGTAATCAATGCCAACAAATTGCGCCGGTATCTACTCGCCAAGCAAAATGTCAATGCGGAGGCTTATG
GACACTGGATTATCAACCGCCTAAATTCGATCTCAACGAGATTGATCAGTATGAGTGGAACTTATTTCGTTATCGAAAAT
TTATTGCTTTGCAAGATGAAAGTTGGCGTGATATTTCCTTGGGTGAGGGGATGACGCCGATAGTCCGCTTTGATGAAAAT
GTATTATTAAAAATGGATTATTTTATGCCAACGCTTTCCTTTAAAGACCGTGGTGCGGCGGTACTTATCAGTCATTGTAA
GTCGATTGGTGTTGATTCAGTGGTACAAGATAGTGGTGGTAATGCAGGCAATAGTGTTGCAGCCTATTGTGCTAAAGCGG
GTATTCAATGTGAAATTTTTGTACCGGAAGGAACATCGCCGAAAAAAATTAATATGATTGAGGCGCATGGTGCTAAAGCT
AATGTGATTAAAGGTAGCCGTGATCATTGTGCAGATGTATGTCGTGCTAAAGTTGAAAATGAGGGCGTTTATTATGCCAA
TCACGTGTATAACCCCTTCTTCTACGAAGGTACGAAAACCTATATTTATGAAACGTTTGAACAGCTCGGGCGGATTCCAA
AACATATTGTCGTTCCGGTTGGAAACGGTACTTTGTTTATTGGTGTCATTAAAGGACTAGAACATTTGTTGGAAAGTGGC
GTTATTGATGAAATGCCAACGATTATTGCATTACAAAGCGAATATTGTGATCCATTATTGCAAGCGGTCAAAAAAGGGCA
AAAATTTGCAGAACAGGTTGAGATTAAGCCGACTATCGCCGAAGGTATTGCCATTGGGCAGCCTATGCGAGCAAGTGAAA
TTTTAGCTTATGCGGAAAAATATGCGATTCGTTTTGTTCATGCTCCGGAAGATAAAATTCTTGCGGCACGAAACGCTTTA
GCCAAAAAAGGGATTTATTGTGAACACACTACCGCAGCTAACTATGCGGCTTATCTTCACTACTGTGAGCTATATGGTGC
AGTAGAAGAATGCTTAATTACGATATGTGGTGCCGGACTGAAATCAGACCATTAA

Upstream 100 bases:

>100_bases
TCGCACAAGCCAGCCCGTACCGTTGTACCTTGCGGTAATTTGCATTACAACGCACTTATAGAAATTGACGCGGTTGCCGA
ATTTGCTTAGGAGAATCAAT

Downstream 100 bases:

>100_bases
CTAAGGGAAATAATATGTCGGAAAAAACATTCGAAAATTTGACCGCACTTTTAGACCAATATCAAGCTCGTTATCGAGTA
GTCCATCATACTAGTGCCGG

Product: putative threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKFICNQCQQIAPVSTRQAKCQCGGLWTLDYQPPKFDLNEIDQYEWNLFRYRKFIALQDESWRDISLGEGMTPIVRFDEN
VLLKMDYFMPTLSFKDRGAAVLISHCKSIGVDSVVQDSGGNAGNSVAAYCAKAGIQCEIFVPEGTSPKKINMIEAHGAKA
NVIKGSRDHCADVCRAKVENEGVYYANHVYNPFFYEGTKTYIYETFEQLGRIPKHIVVPVGNGTLFIGVIKGLEHLLESG
VIDEMPTIIALQSEYCDPLLQAVKKGQKFAEQVEIKPTIAEGIAIGQPMRASEILAYAEKYAIRFVHAPEDKILAARNAL
AKKGIYCEHTTAANYAAYLHYCELYGAVEECLITICGAGLKSDH

Sequences:

>Translated_364_residues
MKFICNQCQQIAPVSTRQAKCQCGGLWTLDYQPPKFDLNEIDQYEWNLFRYRKFIALQDESWRDISLGEGMTPIVRFDEN
VLLKMDYFMPTLSFKDRGAAVLISHCKSIGVDSVVQDSGGNAGNSVAAYCAKAGIQCEIFVPEGTSPKKINMIEAHGAKA
NVIKGSRDHCADVCRAKVENEGVYYANHVYNPFFYEGTKTYIYETFEQLGRIPKHIVVPVGNGTLFIGVIKGLEHLLESG
VIDEMPTIIALQSEYCDPLLQAVKKGQKFAEQVEIKPTIAEGIAIGQPMRASEILAYAEKYAIRFVHAPEDKILAARNAL
AKKGIYCEHTTAANYAAYLHYCELYGAVEECLITICGAGLKSDH
>Mature_364_residues
MKFICNQCQQIAPVSTRQAKCQCGGLWTLDYQPPKFDLNEIDQYEWNLFRYRKFIALQDESWRDISLGEGMTPIVRFDEN
VLLKMDYFMPTLSFKDRGAAVLISHCKSIGVDSVVQDSGGNAGNSVAAYCAKAGIQCEIFVPEGTSPKKINMIEAHGAKA
NVIKGSRDHCADVCRAKVENEGVYYANHVYNPFFYEGTKTYIYETFEQLGRIPKHIVVPVGNGTLFIGVIKGLEHLLESG
VIDEMPTIIALQSEYCDPLLQAVKKGQKFAEQVEIKPTIAEGIAIGQPMRASEILAYAEKYAIRFVHAPEDKILAARNAL
AKKGIYCEHTTAANYAAYLHYCELYGAVEECLITICGAGLKSDH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319788, Length=250, Percent_Identity=28.8, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 40477; Mature: 40477

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFICNQCQQIAPVSTRQAKCQCGGLWTLDYQPPKFDLNEIDQYEWNLFRYRKFIALQDE
CCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
SWRDISLGEGMTPIVRFDENVLLKMDYFMPTLSFKDRGAAVLISHCKSIGVDSVVQDSGG
CCCEECCCCCCCCEEEECCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCC
NAGNSVAAYCAKAGIQCEIFVPEGTSPKKINMIEAHGAKANVIKGSRDHCADVCRAKVEN
CCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCC
EGVYYANHVYNPFFYEGTKTYIYETFEQLGRIPKHIVVPVGNGTLFIGVIKGLEHLLESG
CCEEEECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHCC
VIDEMPTIIALQSEYCDPLLQAVKKGQKFAEQVEIKPTIAEGIAIGQPMRASEILAYAEK
CHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHH
YAIRFVHAPEDKILAARNALAKKGIYCEHTTAANYAAYLHYCELYGAVEECLITICGAGL
HEEEEEECCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KSDH
CCCC
>Mature Secondary Structure
MKFICNQCQQIAPVSTRQAKCQCGGLWTLDYQPPKFDLNEIDQYEWNLFRYRKFIALQDE
CCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
SWRDISLGEGMTPIVRFDENVLLKMDYFMPTLSFKDRGAAVLISHCKSIGVDSVVQDSGG
CCCEECCCCCCCCEEEECCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCC
NAGNSVAAYCAKAGIQCEIFVPEGTSPKKINMIEAHGAKANVIKGSRDHCADVCRAKVEN
CCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCC
EGVYYANHVYNPFFYEGTKTYIYETFEQLGRIPKHIVVPVGNGTLFIGVIKGLEHLLESG
CCEEEECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHCC
VIDEMPTIIALQSEYCDPLLQAVKKGQKFAEQVEIKPTIAEGIAIGQPMRASEILAYAEK
CHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHH
YAIRFVHAPEDKILAARNALAKKGIYCEHTTAANYAAYLHYCELYGAVEECLITICGAGL
HEEEEEECCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KSDH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]