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The map label for this gene is apt

Identifier: 126207754

GI number: 126207754

Start: 295811

End: 296350

Strand: Reverse

Name: apt

Synonym: APL_0266

Alternate gene names: 126207754

Gene position: 296350-295811 (Counterclockwise)

Preceding gene: 126207759

Following gene: 126207753

Centisome position: 13.03

GC content: 41.85

Gene sequence:

>540_bases
ATGAACCAATTAGATTTAATCAAATCTTCTATCAAATCGATTCCCGACTATCCGAAAGCGGGAATTATTTTCCGTGACAT
TACTTCATTATTAGAAGTGCCGGAAGCATTCAAAGCCACCGTAGATGCCATCGTTGCCGAATTTAAAGATAAAGGCATTA
CTAAAGTAGTCGGAACCGAGTCTCGCGGCTTTATCTTCGGCGCACCGGTAGCGCTTGCATTAGGCGTACCGTTTGTCTTA
GTTCGTAAACCGAAAAAATTACCTCGTGCCGTGATTTCACAATCTTACGCTCTAGAATACGGTGAAGATACGCTGGAAAT
CCACTTAGATTCAGTAAAAGAAAACGATAACGTATTAATGGTGGACGATTTATTAGCCACCGGCGGTACGATTGATGCAA
CGGCAAAATTAATTCGTCGTTTAGGCGGTAAAGTAGAACACGCCGCCTTTGTGATTTGGTTACCGGATTTAGGCGGTAAA
GAACGTTTAGAAAAAGAAGGTATCAACTCATTCACATTGGTTGAGTTTGCCGGTCATTAA

Upstream 100 bases:

>100_bases
AAATGATGCCGAATTACTGACTTCCCTTAAATTTTCCTTGTAATTTTGCTCAATTTTGCTAAATTCTTCAGGTTATTTTG
CTATTTTTTAAGGTCTAACC

Downstream 100 bases:

>100_bases
TATTTGTTAGCACGGAGTGCGTACATTCCGTACTAAATAAGAGTCGCAATGAGTTATCAAGTTTTAGCCCGTAAATGGCG
TCCGCAACGTTTTTCGGAAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNQLDLIKSSIKSIPDYPKAGIIFRDITSLLEVPEAFKATVDAIVAEFKDKGITKVVGTESRGFIFGAPVALALGVPFVL
VRKPKKLPRAVISQSYALEYGEDTLEIHLDSVKENDNVLMVDDLLATGGTIDATAKLIRRLGGKVEHAAFVIWLPDLGGK
ERLEKEGINSFTLVEFAGH

Sequences:

>Translated_179_residues
MNQLDLIKSSIKSIPDYPKAGIIFRDITSLLEVPEAFKATVDAIVAEFKDKGITKVVGTESRGFIFGAPVALALGVPFVL
VRKPKKLPRAVISQSYALEYGEDTLEIHLDSVKENDNVLMVDDLLATGGTIDATAKLIRRLGGKVEHAAFVIWLPDLGGK
ERLEKEGINSFTLVEFAGH
>Mature_179_residues
MNQLDLIKSSIKSIPDYPKAGIIFRDITSLLEVPEAFKATVDAIVAEFKDKGITKVVGTESRGFIFGAPVALALGVPFVL
VRKPKKLPRAVISQSYALEYGEDTLEIHLDSVKENDNVLMVDDLLATGGTIDATAKLIRRLGGKVEHAAFVIWLPDLGGK
ERLEKEGINSFTLVEFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=178, Percent_Identity=38.2022471910112, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=41.5384615384615, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1786675, Length=178, Percent_Identity=66.8539325842697, Blast_Score=243, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17509087, Length=172, Percent_Identity=42.4418604651163, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=37.888198757764, Blast_Score=100, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=40, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ACTP2 (A3MYY8)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052979.1
- ProteinModelPortal:   A3MYY8
- SMR:   A3MYY8
- STRING:   A3MYY8
- GeneID:   4850209
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0266
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A3MYY8
- ProtClustDB:   PRK02304
- BioCyc:   APLE416269:APL_0266-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19491; Mature: 19491

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLDLIKSSIKSIPDYPKAGIIFRDITSLLEVPEAFKATVDAIVAEFKDKGITKVVGTE
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCC
SRGFIFGAPVALALGVPFVLVRKPKKLPRAVISQSYALEYGEDTLEIHLDSVKENDNVLM
CCCEEEECHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEE
VDDLLATGGTIDATAKLIRRLGGKVEHAAFVIWLPDLGGKERLEKEGINSFTLVEFAGH
EEHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MNQLDLIKSSIKSIPDYPKAGIIFRDITSLLEVPEAFKATVDAIVAEFKDKGITKVVGTE
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEECCC
SRGFIFGAPVALALGVPFVLVRKPKKLPRAVISQSYALEYGEDTLEIHLDSVKENDNVLM
CCCEEEECHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEE
VDDLLATGGTIDATAKLIRRLGGKVEHAAFVIWLPDLGGKERLEKEGINSFTLVEFAGH
EEHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA