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The map label for this gene is dnaX [H]

Identifier: 126207753

GI number: 126207753

Start: 293696

End: 295762

Strand: Reverse

Name: dnaX [H]

Synonym: APL_0265

Alternate gene names: 126207753

Gene position: 295762-293696 (Counterclockwise)

Preceding gene: 126207754

Following gene: 126207752

Centisome position: 13.0

GC content: 44.07

Gene sequence:

>2067_bases
ATGAGTTATCAAGTTTTAGCCCGTAAATGGCGTCCGCAACGTTTTTCGGAAGTTGTCGGACAGCAACACGTTTTATCCGC
ACTAGAAAATGGTCTGCGAGAAGGCAGACTTCATCACGCCTACCTGTTTTCCGGTACGCGCGGAGTAGGTAAAACCTCAA
TTGCACGTCTATTTGCAAAAGGCTTAAACTGCGAAACCGGTATCACCGCAACTCCCTGTGGTGAATGTGCAAATTGTAAA
GCGATCGAAGAAGGTCGCTTTATTGATCTGATTGAAATTGATGCGGCTTCACGTACTAAAGTCGAAGACACTCGTGAGTT
GCTTGATAACGTTCAATACAAACCGACCGTCGGACGCTTTAAAGTTTACTTGATTGACGAAGTGCATATGCTCTCTCGTC
ACAGTTTCAATGCGTTACTTAAAACGCTTGAAGAACCGCCGGAATACGTGAAGTTCTTACTCGCAACGACAGATCCACAA
AAATTACCAATTACGATCTTATCCCGTTGTATGCAATTCCATTTGCGTGCATTAGATCAAGCTCAGATCGCAAACCACCT
CGAATTTATCCTGCAACAGGAGAATATTCCCTACGAGTCAGTCGCTATTGAAAAACTAGCAAAAGCGGCTCAAGGCAGTA
TTCGTGATTCATTAAGTTTAACTGATCAGGCAATTGCGGTAAGTAATGCGAATATTAGCTTACCAATCGTACAGCAAATG
CTCGGTTTAATTGATGATCACCAGCCAATCGAATTAGTCACTGCGCTTGCACAAGCAGACGGTGAAAAAGCGATGGCGGT
TATTCAATCTGTGGCGGAAAAAGGGATTGATTGGTCGCAATTACTCTCTGATATAGCTCAAACTTTGCACCAAATTGCGA
TGCTTCAGTTGCTCAAAAATAACGGGCAGGAACAAACTCAGTTACATTTTTTAGCGAAACAAATTGCGCCTGAAGACGTA
CAGTTTTTCTACCAATTAATGCTTAACGGTAAGAAAGAATTGGAATTCGCACCGGAACAACGTGCCGGTGTGGAAATGAC
CATTTTACGAGCATTGGCTTTCCATCCGAAACGTACCGAAGAGCTCAATCGTCATCCGGTAATGGAAGCGGCGAAAGCAA
CAAGCGCGCAACCTCATACACCTCAACAGAATATTGAACAGCTCAAAGCTCGTTTAAACCAGAATCATACGCAACAAGCG
GTTAATTCTGTCCAAAATGTTGCAACACAACCTGTTGCAAAAATGCCGGAAAATCCAACCGCTTACCAACAACCAGCCGT
AAATACGACTGAAAGCGGTTCTACACCGGTATCACCCGCTCTTGCGGCAATGCAAGCCCGTAAGCAATTACAGCGAACTC
AGGCACAACTGGCTCAAAACGAAAAAAAAAAGCCTGAGTTAGTTAAACCGGCTACTCTACCCGCAAGCCGAGCGAATCCA
CAAAAAACGCCAAGTTTACAAGAGCGTTTTATGAATTTGGCAACCGAGCAACAGGCACAATCTCGGCCTCAACCGACACA
GCAAGCGGCAAAACCGCTAAGTGATGAAGATTATCGTTGGACGTGGCTCAATCCCGAATTAGAAACCCAAAACGAAAGTA
CCAAACCGTCCGATATCAAGCAAGCAATCCTACAAGAACGTACGCCGGAATTAGTCGCAAAAACCATTGCATTATCTTGC
GAGCAAGACGAATGGTGCAAAATTGTAAATGAGTTAAAGCTCGGCGGCTTATCTCGCCAAGTGGCGTTAAACAGCTATTT
AGCCGAAAAACAAGGTGAACGGCTTAAGCTCATTCTTAAACCGGCAATGGCACACTTGGACAATGCCGAATCTCGTCAAA
GCCTAGCAACCGCCTTGCAAGAAAAAGGCTTTAGCTATGAATTGAGTATCGGCAAAAGTGCGGAACATAAAACACCGCTT
GAAATTCGTCGCGCCATTTTTGAAAATTTAACGCTCGAAGCGAAAAAAGCACTTACTCATGATGAAAAATTAATGCTGTT
ACGCCAAACTTTTGATGCGGAAATCGATGAAAGTACGATTCGAGCCGTTGCAGAGAATAAAGAATAA

Upstream 100 bases:

>100_bases
AGAAAAAGAAGGTATCAACTCATTCACATTGGTTGAGTTTGCCGGTCATTAATATTTGTTAGCACGGAGTGCGTACATTC
CGTACTAAATAAGAGTCGCA

Downstream 100 bases:

>100_bases
TGAACGCTTTAGAAATTACCAATCTTATTAAAACCTACCCGACCGGCGTGCAAGCGGTAAAAGGAATCGATCTCATCGTA
GAACAGGGCGATTTTTACGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSYQVLARKWRPQRFSEVVGQQHVLSALENGLREGRLHHAYLFSGTRGVGKTSIARLFAKGLNCETGITATPCGECANCK
AIEEGRFIDLIEIDAASRTKVEDTRELLDNVQYKPTVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPITILSRCMQFHLRALDQAQIANHLEFILQQENIPYESVAIEKLAKAAQGSIRDSLSLTDQAIAVSNANISLPIVQQM
LGLIDDHQPIELVTALAQADGEKAMAVIQSVAEKGIDWSQLLSDIAQTLHQIAMLQLLKNNGQEQTQLHFLAKQIAPEDV
QFFYQLMLNGKKELEFAPEQRAGVEMTILRALAFHPKRTEELNRHPVMEAAKATSAQPHTPQQNIEQLKARLNQNHTQQA
VNSVQNVATQPVAKMPENPTAYQQPAVNTTESGSTPVSPALAAMQARKQLQRTQAQLAQNEKKKPELVKPATLPASRANP
QKTPSLQERFMNLATEQQAQSRPQPTQQAAKPLSDEDYRWTWLNPELETQNESTKPSDIKQAILQERTPELVAKTIALSC
EQDEWCKIVNELKLGGLSRQVALNSYLAEKQGERLKLILKPAMAHLDNAESRQSLATALQEKGFSYELSIGKSAEHKTPL
EIRRAIFENLTLEAKKALTHDEKLMLLRQTFDAEIDESTIRAVAENKE

Sequences:

>Translated_688_residues
MSYQVLARKWRPQRFSEVVGQQHVLSALENGLREGRLHHAYLFSGTRGVGKTSIARLFAKGLNCETGITATPCGECANCK
AIEEGRFIDLIEIDAASRTKVEDTRELLDNVQYKPTVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPITILSRCMQFHLRALDQAQIANHLEFILQQENIPYESVAIEKLAKAAQGSIRDSLSLTDQAIAVSNANISLPIVQQM
LGLIDDHQPIELVTALAQADGEKAMAVIQSVAEKGIDWSQLLSDIAQTLHQIAMLQLLKNNGQEQTQLHFLAKQIAPEDV
QFFYQLMLNGKKELEFAPEQRAGVEMTILRALAFHPKRTEELNRHPVMEAAKATSAQPHTPQQNIEQLKARLNQNHTQQA
VNSVQNVATQPVAKMPENPTAYQQPAVNTTESGSTPVSPALAAMQARKQLQRTQAQLAQNEKKKPELVKPATLPASRANP
QKTPSLQERFMNLATEQQAQSRPQPTQQAAKPLSDEDYRWTWLNPELETQNESTKPSDIKQAILQERTPELVAKTIALSC
EQDEWCKIVNELKLGGLSRQVALNSYLAEKQGERLKLILKPAMAHLDNAESRQSLATALQEKGFSYELSIGKSAEHKTPL
EIRRAIFENLTLEAKKALTHDEKLMLLRQTFDAEIDESTIRAVAENKE
>Mature_687_residues
SYQVLARKWRPQRFSEVVGQQHVLSALENGLREGRLHHAYLFSGTRGVGKTSIARLFAKGLNCETGITATPCGECANCKA
IEEGRFIDLIEIDAASRTKVEDTRELLDNVQYKPTVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQK
LPITILSRCMQFHLRALDQAQIANHLEFILQQENIPYESVAIEKLAKAAQGSIRDSLSLTDQAIAVSNANISLPIVQQML
GLIDDHQPIELVTALAQADGEKAMAVIQSVAEKGIDWSQLLSDIAQTLHQIAMLQLLKNNGQEQTQLHFLAKQIAPEDVQ
FFYQLMLNGKKELEFAPEQRAGVEMTILRALAFHPKRTEELNRHPVMEAAKATSAQPHTPQQNIEQLKARLNQNHTQQAV
NSVQNVATQPVAKMPENPTAYQQPAVNTTESGSTPVSPALAAMQARKQLQRTQAQLAQNEKKKPELVKPATLPASRANPQ
KTPSLQERFMNLATEQQAQSRPQPTQQAAKPLSDEDYRWTWLNPELETQNESTKPSDIKQAILQERTPELVAKTIALSCE
QDEWCKIVNELKLGGLSRQVALNSYLAEKQGERLKLILKPAMAHLDNAESRQSLATALQEKGFSYELSIGKSAEHKTPLE
IRRAIFENLTLEAKKALTHDEKLMLLRQTFDAEIDESTIRAVAENKE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=300, Percent_Identity=23.3333333333333, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786676, Length=691, Percent_Identity=49.493487698987, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1787341, Length=144, Percent_Identity=31.25, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=288, Percent_Identity=25.3472222222222, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=301, Percent_Identity=22.5913621262458, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324039, Length=317, Percent_Identity=23.0283911671924, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 77049; Mature: 76918

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPQRFSEVVGQQHVLSALENGLREGRLHHAYLFSGTRGVGKTSIARLFAK
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCETGITATPCGECANCKAIEEGRFIDLIEIDAASRTKVEDTRELLDNVQYKPTVGRF
CCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPITILSRCMQFHLRALDQ
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AQIANHLEFILQQENIPYESVAIEKLAKAAQGSIRDSLSLTDQAIAVSNANISLPIVQQM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCCHHHHHHH
LGLIDDHQPIELVTALAQADGEKAMAVIQSVAEKGIDWSQLLSDIAQTLHQIAMLQLLKN
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
NGQEQTQLHFLAKQIAPEDVQFFYQLMLNGKKELEFAPEQRAGVEMTILRALAFHPKRTE
CCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCCHHCCHHHHHHHHHHCCCCHHH
ELNRHPVMEAAKATSAQPHTPQQNIEQLKARLNQNHTQQAVNSVQNVATQPVAKMPENPT
HHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCC
AYQQPAVNTTESGSTPVSPALAAMQARKQLQRTQAQLAQNEKKKPELVKPATLPASRANP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
QKTPSLQERFMNLATEQQAQSRPQPTQQAAKPLSDEDYRWTWLNPELETQNESTKPSDIK
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHH
QAILQERTPELVAKTIALSCEQDEWCKIVNELKLGGLSRQVALNSYLAEKQGERLKLILK
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHH
PAMAHLDNAESRQSLATALQEKGFSYELSIGKSAEHKTPLEIRRAIFENLTLEAKKALTH
HHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCC
DEKLMLLRQTFDAEIDESTIRAVAENKE
HHHHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SYQVLARKWRPQRFSEVVGQQHVLSALENGLREGRLHHAYLFSGTRGVGKTSIARLFAK
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCETGITATPCGECANCKAIEEGRFIDLIEIDAASRTKVEDTRELLDNVQYKPTVGRF
CCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPITILSRCMQFHLRALDQ
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AQIANHLEFILQQENIPYESVAIEKLAKAAQGSIRDSLSLTDQAIAVSNANISLPIVQQM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCCHHHHHHH
LGLIDDHQPIELVTALAQADGEKAMAVIQSVAEKGIDWSQLLSDIAQTLHQIAMLQLLKN
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
NGQEQTQLHFLAKQIAPEDVQFFYQLMLNGKKELEFAPEQRAGVEMTILRALAFHPKRTE
CCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCCHHCCHHHHHHHHHHCCCCHHH
ELNRHPVMEAAKATSAQPHTPQQNIEQLKARLNQNHTQQAVNSVQNVATQPVAKMPENPT
HHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCC
AYQQPAVNTTESGSTPVSPALAAMQARKQLQRTQAQLAQNEKKKPELVKPATLPASRANP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
QKTPSLQERFMNLATEQQAQSRPQPTQQAAKPLSDEDYRWTWLNPELETQNESTKPSDIK
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHH
QAILQERTPELVAKTIALSCEQDEWCKIVNELKLGGLSRQVALNSYLAEKQGERLKLILK
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHH
PAMAHLDNAESRQSLATALQEKGFSYELSIGKSAEHKTPLEIRRAIFENLTLEAKKALTH
HHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCC
DEKLMLLRQTFDAEIDESTIRAVAENKE
HHHHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]