Click here to switch to the map view.

The map label for this gene is iclR [C]

Identifier: 126207596

GI number: 126207596

Start: 127363

End: 128148

Strand: Reverse

Name: iclR [C]

Synonym: APL_0108

Alternate gene names: 126207596

Gene position: 128148-127363 (Counterclockwise)

Preceding gene: 126207597

Following gene: 126207595

Centisome position: 5.63

GC content: 45.17

Gene sequence:

>786_bases
GTGACAGACAAAGAATCCGCAGGAAGCCAAACATTAGTTCGAGGTCTTAAATTACTTGAATTGCTCTCCCAATACCCGAA
CGGTTGTCCGTTAGCTCAACTTTCCGAACTGGCGAATTTAAACAAAAGTACGGTTCATCGCTTATTGCAAAGCCTTCAGC
AAGAAGGATTCGTTCGTCCTGCCCCGACTACCGGAAGCTATCGTTTATCGACCAAATGTTTAGCCATCGGTCAGCGCGCG
CTCAGTTCCCTTAATATCCTACATATCGCCGCACCGCATTTGGAGGCGCTTAACCTGAAGTTAGGCGAAACGGTGAATTT
CGCTATGCGAGAAGGCAATCACGCCATCTTGATTTATAAACTCGAGCCGACAACCGGTATGATGAAAACTCGTGCCTATA
TCGGGCAAAGGCTTCAACTTTATTGTTCCGGTATGGGAAAACTATTTTTAGCCTATGATAAAGCGGAATACATTCCGCAT
TATTGGGAAATCCAACACGATACCATTCAACAATTAACACCGAATACAATTACTACGGTGCCGGCGATGAATGCCGAGCT
TGAAAAGATCCGCCGACAACAATTTGCGATGGATGACGAAGAAAACGAAATGGGCGTTTCATGTATCGCTTGTCCTATTT
TTGATCATCAAGGACAAGTAAATTATGCCATATCCATCTCGCTTTCTACCGCAAGACTGAAACAAGTCGGGATCGATACG
TTACGTTCGGAACTTCAAACCACCGCGCATAAGATCTCGGAAGAACTAGGCTGGATCTTCCCGTAA

Upstream 100 bases:

>100_bases
CGATAAGCGTAGGGCTTGCATATCCGTTTCAATTTGTTGAGAATTTACCGACGGAACCTTGGGATATACCGCTTAACCAC
TTGATCATAGGAGATATAAA

Downstream 100 bases:

>100_bases
GCGGTCGATAATTCCACATTTTTAGCAAAATCTCAGCGAAAATCTGATTGTATATTCAGGTATTTTTTCTATCCACAAAA
ACTGTGGATAACTTTGTGGA

Product: putative HTH-type transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTDKESAGSQTLVRGLKLLELLSQYPNGCPLAQLSELANLNKSTVHRLLQSLQQEGFVRPAPTTGSYRLSTKCLAIGQRA
LSSLNILHIAAPHLEALNLKLGETVNFAMREGNHAILIYKLEPTTGMMKTRAYIGQRLQLYCSGMGKLFLAYDKAEYIPH
YWEIQHDTIQQLTPNTITTVPAMNAELEKIRRQQFAMDDEENEMGVSCIACPIFDHQGQVNYAISISLSTARLKQVGIDT
LRSELQTTAHKISEELGWIFP

Sequences:

>Translated_261_residues
MTDKESAGSQTLVRGLKLLELLSQYPNGCPLAQLSELANLNKSTVHRLLQSLQQEGFVRPAPTTGSYRLSTKCLAIGQRA
LSSLNILHIAAPHLEALNLKLGETVNFAMREGNHAILIYKLEPTTGMMKTRAYIGQRLQLYCSGMGKLFLAYDKAEYIPH
YWEIQHDTIQQLTPNTITTVPAMNAELEKIRRQQFAMDDEENEMGVSCIACPIFDHQGQVNYAISISLSTARLKQVGIDT
LRSELQTTAHKISEELGWIFP
>Mature_260_residues
TDKESAGSQTLVRGLKLLELLSQYPNGCPLAQLSELANLNKSTVHRLLQSLQQEGFVRPAPTTGSYRLSTKCLAIGQRAL
SSLNILHIAAPHLEALNLKLGETVNFAMREGNHAILIYKLEPTTGMMKTRAYIGQRLQLYCSGMGKLFLAYDKAEYIPHY
WEIQHDTIQQLTPNTITTVPAMNAELEKIRRQQFAMDDEENEMGVSCIACPIFDHQGQVNYAISISLSTARLKQVGIDTL
RSELQTTAHKISEELGWIFP

Specific function: Unknown

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1789999, Length=252, Percent_Identity=65.8730158730159, Blast_Score=342, Evalue=1e-95,
Organism=Escherichia coli, GI1786468, Length=252, Percent_Identity=31.7460317460317, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786715, Length=250, Percent_Identity=34, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082359, Length=225, Percent_Identity=34.2222222222222, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788131, Length=259, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790752, Length=254, Percent_Identity=29.9212598425197, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788581, Length=262, Percent_Identity=28.2442748091603, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29174; Mature: 29043

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKESAGSQTLVRGLKLLELLSQYPNGCPLAQLSELANLNKSTVHRLLQSLQQEGFVRP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
APTTGSYRLSTKCLAIGQRALSSLNILHIAAPHLEALNLKLGETVNFAMREGNHAILIYK
CCCCCCEEEHHHHHHHHHHHHHHCCEEEEECCCHHHHCEECCCCEEHHEECCCCEEEEEE
LEPTTGMMKTRAYIGQRLQLYCSGMGKLFLAYDKAEYIPHYWEIQHDTIQQLTPNTITTV
ECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCCCEECCHHHHHHCCCCCEEEC
PAMNAELEKIRRQQFAMDDEENEMGVSCIACPIFDHQGQVNYAISISLSTARLKQVGIDT
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEEEHHHHHHHHHHHH
LRSELQTTAHKISEELGWIFP
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDKESAGSQTLVRGLKLLELLSQYPNGCPLAQLSELANLNKSTVHRLLQSLQQEGFVRP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
APTTGSYRLSTKCLAIGQRALSSLNILHIAAPHLEALNLKLGETVNFAMREGNHAILIYK
CCCCCCEEEHHHHHHHHHHHHHHCCEEEEECCCHHHHCEECCCCEEHHEECCCCEEEEEE
LEPTTGMMKTRAYIGQRLQLYCSGMGKLFLAYDKAEYIPHYWEIQHDTIQQLTPNTITTV
ECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCCCEECCHHHHHHCCCCCEEEC
PAMNAELEKIRRQQFAMDDEENEMGVSCIACPIFDHQGQVNYAISISLSTARLKQVGIDT
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEEEHHHHHHHHHHHH
LRSELQTTAHKISEELGWIFP
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]