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The map label for this gene is dppA [H]

Identifier: 126207551

GI number: 126207551

Start: 75007

End: 76602

Strand: Direct

Name: dppA [H]

Synonym: APL_0063

Alternate gene names: 126207551

Gene position: 75007-76602 (Clockwise)

Preceding gene: 126207549

Following gene: 126207552

Centisome position: 3.3

GC content: 38.91

Gene sequence:

>1596_bases
ATGCAAAAATATTTTTCCTTATCAGCACTTGCATTAGTGTTGTTTTCTAATACTGTATTTGCTTCCCCTAAAACTTTTAC
CTATTGTATCGAATCTTCCCCAGCCTTTTTAAATCCGCAAATTGGTACAGACGGCGCGACCTTAGATGTGGCACAAGCGT
TATATAACCGTTTAATTGATTTTGAACCGGGTACAACTAATCTTGTTCCTTCCTTAGCTGAAAAATGGGATATTTCTGCG
GACGGGAAAACTTATACCTTTTATTTACGTAAAGGCGTTAAATTTCATAAAAATAAAGAATTTACGCCATCCCGCAATTT
CAATGCCGATGATGTGCTATTCGTCTTTAATCGCCAATTAAATAAATACAATTATTTCCATAATGTTTCGGGCGGTAACT
ACGAGTTTTTCTTAGGTATGGATATGCCTAATATCATTGAAAAAGTCGAGAAAGTGGATACTTACGTGGTTAAATTCCAC
TTAAAAGTGCCGAATGCACCGTTTTTAGCAAATCTTGCAATGGATTTCGCTTCGATTTCATCTTCAGAGTATGCAGATCA
AATGTTAAAAGCCGGTACGCCGGAAAAAGTGGATACCGCACCGATTGGTACCGGACCGTTTGAGTTCGCCGGTTTACAAA
AAGATGCTTATGTACGTTTTAAAGCATTTGATGATTATTGGCAGGGTAGAGCAAAATTAGACCGCTTAGTCTTTAGTGTG
ACGCCGGATGCGACTGTTCGTTATGCCAAATTGCAGAAAAATGAATGTCAGGCAATGCCTTATCCGAATCCGGCAGATAT
TGCTCAGATGAAAGCTGATACTAATTTACAGGTATTAGAAAAATCTGGACTAAATATCGGCTACATTACTTTTAATTTGG
ATAAGAAGCCGTTGGATAATCAAAAGGTTCGCCAAGCACTCAATTATGCGGTAAATAAGCAAGCGATTTTAGAATCGGTT
TATCAAGGTACAGGATCAGCTGCGAAAAATCCGATGCCACCGACAATTTGGGGCTATAACGATGAAATTCAGGATTATGA
ATATAATCCTGAGAAAGCGAAAGCATTATTAAAAGAAGCCGGATTGGAAAACGGTTTTGATACGGAATTATGGGCAATGC
CGGTTTCCCGTCCTTATAATCCGAATGCGCGCCGTATGGCTGAAATGGTTCAAGAAGATTGGAAGCAAATCGGGGTGAAT
GCCAAAATTGTGAGTTTTGAATGGGGGGAATATCTCAAACGAATGGAACAAGGCGAACATTCAACCGGTATGATGGGGTG
GACAGGCGACAATGGCGATCCGGATAACTTCTTAAATACATTATTAAGTTGTAATGCGGTAAAACAAGGTTCGAATTATG
CCCATTTTTGCGATCAATCTTATAATGATTTAGTGACGCAAGCGGCGCAAGAATCGGATAAAGCAAAACGAGAAGCACTT
TATAAACAGGCACAAGTGATTTTTAAACAACAAGCACCTTGGCTTCCTATTGCACATTCGACGACTTATTTCCCAATGCG
TAAAGAAGTAAAAGGTTATACGGTTAGCCCTTTTTTATCACATAACTTTTATCGGGTCGAGTTAGAAAATAACTAA

Upstream 100 bases:

>100_bases
TTATAATTACCTTACGATTGAACGTTGCAATATGAAATAGGGCTGATAATATGTAAATTATTGGATAGAAATAATTTATA
ACACAGCGTCAGGATATTTC

Downstream 100 bases:

>100_bases
TAGAGTATAGTAAATATGATAAGCGGTCTAGATTTTGCGGAAATTTGCAAATTTTCGTTGAATTTAGACCGCTTTTTACT
GAAAAAGTATTGAACTTCAT

Product: periplasmic dipeptide transport protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MQKYFSLSALALVLFSNTVFASPKTFTYCIESSPAFLNPQIGTDGATLDVAQALYNRLIDFEPGTTNLVPSLAEKWDISA
DGKTYTFYLRKGVKFHKNKEFTPSRNFNADDVLFVFNRQLNKYNYFHNVSGGNYEFFLGMDMPNIIEKVEKVDTYVVKFH
LKVPNAPFLANLAMDFASISSSEYADQMLKAGTPEKVDTAPIGTGPFEFAGLQKDAYVRFKAFDDYWQGRAKLDRLVFSV
TPDATVRYAKLQKNECQAMPYPNPADIAQMKADTNLQVLEKSGLNIGYITFNLDKKPLDNQKVRQALNYAVNKQAILESV
YQGTGSAAKNPMPPTIWGYNDEIQDYEYNPEKAKALLKEAGLENGFDTELWAMPVSRPYNPNARRMAEMVQEDWKQIGVN
AKIVSFEWGEYLKRMEQGEHSTGMMGWTGDNGDPDNFLNTLLSCNAVKQGSNYAHFCDQSYNDLVTQAAQESDKAKREAL
YKQAQVIFKQQAPWLPIAHSTTYFPMRKEVKGYTVSPFLSHNFYRVELENN

Sequences:

>Translated_531_residues
MQKYFSLSALALVLFSNTVFASPKTFTYCIESSPAFLNPQIGTDGATLDVAQALYNRLIDFEPGTTNLVPSLAEKWDISA
DGKTYTFYLRKGVKFHKNKEFTPSRNFNADDVLFVFNRQLNKYNYFHNVSGGNYEFFLGMDMPNIIEKVEKVDTYVVKFH
LKVPNAPFLANLAMDFASISSSEYADQMLKAGTPEKVDTAPIGTGPFEFAGLQKDAYVRFKAFDDYWQGRAKLDRLVFSV
TPDATVRYAKLQKNECQAMPYPNPADIAQMKADTNLQVLEKSGLNIGYITFNLDKKPLDNQKVRQALNYAVNKQAILESV
YQGTGSAAKNPMPPTIWGYNDEIQDYEYNPEKAKALLKEAGLENGFDTELWAMPVSRPYNPNARRMAEMVQEDWKQIGVN
AKIVSFEWGEYLKRMEQGEHSTGMMGWTGDNGDPDNFLNTLLSCNAVKQGSNYAHFCDQSYNDLVTQAAQESDKAKREAL
YKQAQVIFKQQAPWLPIAHSTTYFPMRKEVKGYTVSPFLSHNFYRVELENN
>Mature_531_residues
MQKYFSLSALALVLFSNTVFASPKTFTYCIESSPAFLNPQIGTDGATLDVAQALYNRLIDFEPGTTNLVPSLAEKWDISA
DGKTYTFYLRKGVKFHKNKEFTPSRNFNADDVLFVFNRQLNKYNYFHNVSGGNYEFFLGMDMPNIIEKVEKVDTYVVKFH
LKVPNAPFLANLAMDFASISSSEYADQMLKAGTPEKVDTAPIGTGPFEFAGLQKDAYVRFKAFDDYWQGRAKLDRLVFSV
TPDATVRYAKLQKNECQAMPYPNPADIAQMKADTNLQVLEKSGLNIGYITFNLDKKPLDNQKVRQALNYAVNKQAILESV
YQGTGSAAKNPMPPTIWGYNDEIQDYEYNPEKAKALLKEAGLENGFDTELWAMPVSRPYNPNARRMAEMVQEDWKQIGVN
AKIVSFEWGEYLKRMEQGEHSTGMMGWTGDNGDPDNFLNTLLSCNAVKQGSNYAHFCDQSYNDLVTQAAQESDKAKREAL
YKQAQVIFKQQAPWLPIAHSTTYFPMRKEVKGYTVSPFLSHNFYRVELENN

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=523, Percent_Identity=62.7151051625239, Blast_Score=701, Evalue=0.0,
Organism=Escherichia coli, GI1787551, Length=536, Percent_Identity=35.0746268656716, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1787052, Length=536, Percent_Identity=29.4776119402985, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787762, Length=530, Percent_Identity=24.7169811320755, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789887, Length=551, Percent_Identity=24.8638838475499, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081878, Length=527, Percent_Identity=25.6166982922201, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789397, Length=249, Percent_Identity=34.136546184739, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787495, Length=541, Percent_Identity=22.181146025878, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 60218; Mature: 60218

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYFSLSALALVLFSNTVFASPKTFTYCIESSPAFLNPQIGTDGATLDVAQALYNRLID
CCCHHHHHHHHHHHHHCCEECCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHCC
FEPGTTNLVPSLAEKWDISADGKTYTFYLRKGVKFHKNKEFTPSRNFNADDVLFVFNRQL
CCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCEEEEEECCC
NKYNYFHNVSGGNYEFFLGMDMPNIIEKVEKVDTYVVKFHLKVPNAPFLANLAMDFASIS
CCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHHHCC
SSEYADQMLKAGTPEKVDTAPIGTGPFEFAGLQKDAYVRFKAFDDYWQGRAKLDRLVFSV
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEECHHHHCCHHHHHHEEEEE
TPDATVRYAKLQKNECQAMPYPNPADIAQMKADTNLQVLEKSGLNIGYITFNLDKKPLDN
CCCCEEEEEHHCCCCCCCCCCCCHHHHHHHCCCCCCEEHHHCCCEEEEEEEECCCCCCCH
QKVRQALNYAVNKQAILESVYQGTGSAAKNPMPPTIWGYNDEIQDYEYNPEKAKALLKEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHC
GLENGFDTELWAMPVSRPYNPNARRMAEMVQEDWKQIGVNAKIVSFEWGEYLKRMEQGEH
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCC
STGMMGWTGDNGDPDNFLNTLLSCNAVKQGSNYAHFCDQSYNDLVTQAAQESDKAKREAL
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
YKQAQVIFKQQAPWLPIAHSTTYFPMRKEVKGYTVSPFLSHNFYRVELENN
HHHHHHHHHHCCCCCEECCCCEECCCHHHCCCEEECHHHCCCEEEEEECCC
>Mature Secondary Structure
MQKYFSLSALALVLFSNTVFASPKTFTYCIESSPAFLNPQIGTDGATLDVAQALYNRLID
CCCHHHHHHHHHHHHHCCEECCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHCC
FEPGTTNLVPSLAEKWDISADGKTYTFYLRKGVKFHKNKEFTPSRNFNADDVLFVFNRQL
CCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCEEEEEECCC
NKYNYFHNVSGGNYEFFLGMDMPNIIEKVEKVDTYVVKFHLKVPNAPFLANLAMDFASIS
CCCCCEECCCCCCEEEEEECCCHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHHHCC
SSEYADQMLKAGTPEKVDTAPIGTGPFEFAGLQKDAYVRFKAFDDYWQGRAKLDRLVFSV
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEECHHHHCCHHHHHHEEEEE
TPDATVRYAKLQKNECQAMPYPNPADIAQMKADTNLQVLEKSGLNIGYITFNLDKKPLDN
CCCCEEEEEHHCCCCCCCCCCCCHHHHHHHCCCCCCEEHHHCCCEEEEEEEECCCCCCCH
QKVRQALNYAVNKQAILESVYQGTGSAAKNPMPPTIWGYNDEIQDYEYNPEKAKALLKEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHC
GLENGFDTELWAMPVSRPYNPNARRMAEMVQEDWKQIGVNAKIVSFEWGEYLKRMEQGEH
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCC
STGMMGWTGDNGDPDNFLNTLLSCNAVKQGSNYAHFCDQSYNDLVTQAAQESDKAKREAL
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
YKQAQVIFKQQAPWLPIAHSTTYFPMRKEVKGYTVSPFLSHNFYRVELENN
HHHHHHHHHHCCCCCEECCCCEECCCHHHCCCEEECHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]