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The map label for this gene is typA [H]

Identifier: 126207541

GI number: 126207541

Start: 58930

End: 60636

Strand: Direct

Name: typA [H]

Synonym: APL_0053

Alternate gene names: 126207541

Gene position: 58930-60636 (Clockwise)

Preceding gene: 126207540

Following gene: 126207542

Centisome position: 2.59

GC content: 42.53

Gene sequence:

>1707_bases
ATGGACTCAAACGATCTTGAAAAAGAACGTGGTATTACCATTCTTGCAAAAAATACAGCGATTAACTGGAACGATTATCG
TATCAACATCGTAGATACACCGGGACATGCGGACTTCGGCGGTGAAGTAGAACGTGTGCTTTCAATGGTTGATTCTGTGT
TATTAGTGGTAGATGCGTTTGACGGCCCAATGCCGCAAACACGTTTCGTAACGCAAAAAGCATTTGCACACGGTTTAAAA
CCGATCGTAGTTATCAATAAAGTGGACCGTCCGGGCGCACGTCCCGACTGGGTTGTGGATCAAGTATTCGATTTATTCGT
AAACTTAGGTGCAACTGACGAGCAATTAGATTTCCCAATTATTTATGCATCGGCATTAATGGGTGTTGCCGGTTTAGAAC
ACGAAGATCTTGCGGAAGATATGACCCCGTTATTCCAAGCGATCGTTGATCATGTTGAACCGCCGAAAGTGGAATTAAAC
GCACCGTTCCAAATGCAAATTTCGCAATTAGATTACAACAACTATGTAGGTGTAATCGGTATCGGTCGTATCAAACGCGG
TTCAATCAAACCGAACCAAACGGTAACGGTGATCGACTCCGAAGGTAAAACCCGTAACGGTAAAATCGGTCAGGTGTTAG
GTCACTTAGGTTTACAACGTTATGAAGCAAGCGAAGCATTTGCCGGCGACATCATTGCAATCACCGGTTTAGGCGAATTA
AATATCTCGGATACGATTTGTGATATTAACAACGTAGAAGCGTTACCGGCATTAAGTGTTGATGAACCGACCGTAAGTAT
GTTCTTCTGCGTAAATACTTCTCCGTTCTGCGGTCAAGAAGGTAAGTATGTGACTTCTCGTCAAATCCTTGAGCGTTTAA
ACAAAGAATTAGTCCACAACGTAGCATTACGTGTAGAAGAGACACCAAACCCGGATGAATTCCGTGTATCAGGCCGTGGT
GAGTTACATTTATCGGTATTAATCGAAAATATGCGCCGTGAAGGTTACGAATTAGCGGTATCGCGTCCGAAAGTAATCTA
CAAAGAAGAAAACGGTAAAAAACAAGAACCGTTCGAGCAAGTTACCATCGATATCGAAGAGCAACACCAAGGTGCGGTAA
TGGAAGCATTAGGTATCCGTAAAGGTGAAGTGAAAGATATGATTCCGGACGGTAAAGGTCGTACACGTTTAGAATACGTG
ATCCCAAGCCGCGGTTTAATCGGTTTTCGTAACGAATTTATGACGATGACTTCTGGTACAGGTTTACTTTACTCAAGCTT
CAGTCATTATGATGACGTAAAACCGGGTGAAATCGGTCAGCGTAAAAACGGCGTGTTAATTTCTAACGCAACCGGTAAAG
CGCTTGCTTATGCATTATTCGGTTTACAAGAACGCGGTAAATTAATGATCGATCACGGTGTGGATGTTTACGAAGGTCAA
ATTATCGGTATTCACAGCCGTGGTAACGACTTAACCGTAAACTGCTTACAAGGTAAAAAATTAACCAATATGCGTGCATC
GGGTAAAGATGATGCAATCGTATTAACAACTCCGGTTCGTTTGAGTTTAGAACAAGCGTTAGAGTTTATCGATGATGACG
AGTTAGTAGAAGTAACGCCGCAATCAATTCGTGTACGTAAACGTTTATTAACCGAAAATGATCGTAAACGTGCAGGTCGT
ACAACCACAAGTACCAGCACGAAATAA

Upstream 100 bases:

>100_bases
TATCGCGCACGTTGACCACGGTAAAACAACGCTTGTAGATAAACTTTTACAACAATCAGGCACATTAGGCGAAACTCGTG
GTGACGCGGACGAGCGTGTC

Downstream 100 bases:

>100_bases
TTTGTATTAGTTTAATGAAATGCTCGCTGCTATTACCTAGCAAGCGGGCTTTTTTTTAGGGTTTTTTGCAAAAAGCTGAT
AGAATTCGACCGCTTACCAG

Product: GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MDSNDLEKERGITILAKNTAINWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLVVDAFDGPMPQTRFVTQKAFAHGLK
PIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIIYASALMGVAGLEHEDLAEDMTPLFQAIVDHVEPPKVELN
APFQMQISQLDYNNYVGVIGIGRIKRGSIKPNQTVTVIDSEGKTRNGKIGQVLGHLGLQRYEASEAFAGDIIAITGLGEL
NISDTICDINNVEALPALSVDEPTVSMFFCVNTSPFCGQEGKYVTSRQILERLNKELVHNVALRVEETPNPDEFRVSGRG
ELHLSVLIENMRREGYELAVSRPKVIYKEENGKKQEPFEQVTIDIEEQHQGAVMEALGIRKGEVKDMIPDGKGRTRLEYV
IPSRGLIGFRNEFMTMTSGTGLLYSSFSHYDDVKPGEIGQRKNGVLISNATGKALAYALFGLQERGKLMIDHGVDVYEGQ
IIGIHSRGNDLTVNCLQGKKLTNMRASGKDDAIVLTTPVRLSLEQALEFIDDDELVEVTPQSIRVRKRLLTENDRKRAGR
TTTSTSTK

Sequences:

>Translated_568_residues
MDSNDLEKERGITILAKNTAINWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLVVDAFDGPMPQTRFVTQKAFAHGLK
PIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIIYASALMGVAGLEHEDLAEDMTPLFQAIVDHVEPPKVELN
APFQMQISQLDYNNYVGVIGIGRIKRGSIKPNQTVTVIDSEGKTRNGKIGQVLGHLGLQRYEASEAFAGDIIAITGLGEL
NISDTICDINNVEALPALSVDEPTVSMFFCVNTSPFCGQEGKYVTSRQILERLNKELVHNVALRVEETPNPDEFRVSGRG
ELHLSVLIENMRREGYELAVSRPKVIYKEENGKKQEPFEQVTIDIEEQHQGAVMEALGIRKGEVKDMIPDGKGRTRLEYV
IPSRGLIGFRNEFMTMTSGTGLLYSSFSHYDDVKPGEIGQRKNGVLISNATGKALAYALFGLQERGKLMIDHGVDVYEGQ
IIGIHSRGNDLTVNCLQGKKLTNMRASGKDDAIVLTTPVRLSLEQALEFIDDDELVEVTPQSIRVRKRLLTENDRKRAGR
TTTSTSTK
>Mature_568_residues
MDSNDLEKERGITILAKNTAINWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLVVDAFDGPMPQTRFVTQKAFAHGLK
PIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIIYASALMGVAGLEHEDLAEDMTPLFQAIVDHVEPPKVELN
APFQMQISQLDYNNYVGVIGIGRIKRGSIKPNQTVTVIDSEGKTRNGKIGQVLGHLGLQRYEASEAFAGDIIAITGLGEL
NISDTICDINNVEALPALSVDEPTVSMFFCVNTSPFCGQEGKYVTSRQILERLNKELVHNVALRVEETPNPDEFRVSGRG
ELHLSVLIENMRREGYELAVSRPKVIYKEENGKKQEPFEQVTIDIEEQHQGAVMEALGIRKGEVKDMIPDGKGRTRLEYV
IPSRGLIGFRNEFMTMTSGTGLLYSSFSHYDDVKPGEIGQRKNGVLISNATGKALAYALFGLQERGKLMIDHGVDVYEGQ
IIGIHSRGNDLTVNCLQGKKLTNMRASGKDDAIVLTTPVRLSLEQALEFIDDDELVEVTPQSIRVRKRLLTENDRKRAGR
TTTSTSTK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=477, Percent_Identity=25.9958071278826, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI25306287, Length=420, Percent_Identity=25.2380952380952, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI19923640, Length=123, Percent_Identity=39.0243902439024, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI25306283, Length=123, Percent_Identity=39.0243902439024, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI18390331, Length=102, Percent_Identity=43.1372549019608, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI94966754, Length=94, Percent_Identity=39.3617021276596, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI34147630, Length=228, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI94966752, Length=81, Percent_Identity=41.9753086419753, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI48994988, Length=561, Percent_Identity=83.6007130124777, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=467, Percent_Identity=26.338329764454, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789738, Length=168, Percent_Identity=34.5238095238095, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790835, Length=101, Percent_Identity=33.6633663366337, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789108, Length=266, Percent_Identity=27.0676691729323, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=371, Percent_Identity=27.4932614555256, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=100, Percent_Identity=43, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17556745, Length=448, Percent_Identity=24.5535714285714, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988819, Length=90, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988811, Length=90, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506493, Length=85, Percent_Identity=36.4705882352941, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=457, Percent_Identity=28.2275711159737, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323098, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=233, Percent_Identity=29.1845493562232, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324707, Length=107, Percent_Identity=41.1214953271028, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320593, Length=107, Percent_Identity=41.1214953271028, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322359, Length=169, Percent_Identity=31.3609467455621, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78706572, Length=469, Percent_Identity=24.9466950959488, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24582462, Length=102, Percent_Identity=44.1176470588235, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221458488, Length=87, Percent_Identity=48.2758620689655, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363316, Length=278, Percent_Identity=26.2589928057554, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17864358, Length=278, Percent_Identity=26.2589928057554, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921738, Length=204, Percent_Identity=30.8823529411765, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574573, Length=99, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 62924; Mature: 62924

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNDLEKERGITILAKNTAINWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLVVDAF
CCCCCCHHHCCEEEEEECEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECC
DGPMPQTRFVTQKAFAHGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPI
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHH
IYASALMGVAGLEHEDLAEDMTPLFQAIVDHVEPPKVELNAPFQMQISQLDYNNYVGVIG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEECCCCEEEEEE
IGRIKRGSIKPNQTVTVIDSEGKTRNGKIGQVLGHLGLQRYEASEAFAGDIIAITGLGEL
ECEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
NISDTICDINNVEALPALSVDEPTVSMFFCVNTSPFCGQEGKYVTSRQILERLNKELVHN
CCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHH
VALRVEETPNPDEFRVSGRGELHLSVLIENMRREGYELAVSRPKVIYKEENGKKQEPFEQ
HHEEEECCCCCCCEEECCCCCEEHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCHHH
VTIDIEEQHQGAVMEALGIRKGEVKDMIPDGKGRTRLEYVIPSRGLIGFRNEFMTMTSGT
EEEEECCCCCCHHHHHHCCCCCCHHHCCCCCCCCEEEEEEECCCCCEEECCCEEEEECCC
GLLYSSFSHYDDVKPGEIGQRKNGVLISNATGKALAYALFGLQERGKLMIDHGVDVYEGQ
CCEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCEEECCE
IIGIHSRGNDLTVNCLQGKKLTNMRASGKDDAIVLTTPVRLSLEQALEFIDDDELVEVTP
EEEEEECCCCEEEEEECCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEECH
QSIRVRKRLLTENDRKRAGRTTTSTSTK
HHHHHHHHHHCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MDSNDLEKERGITILAKNTAINWNDYRINIVDTPGHADFGGEVERVLSMVDSVLLVVDAF
CCCCCCHHHCCEEEEEECEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECC
DGPMPQTRFVTQKAFAHGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPI
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHH
IYASALMGVAGLEHEDLAEDMTPLFQAIVDHVEPPKVELNAPFQMQISQLDYNNYVGVIG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEECCCCEEEEEE
IGRIKRGSIKPNQTVTVIDSEGKTRNGKIGQVLGHLGLQRYEASEAFAGDIIAITGLGEL
ECEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
NISDTICDINNVEALPALSVDEPTVSMFFCVNTSPFCGQEGKYVTSRQILERLNKELVHN
CCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHH
VALRVEETPNPDEFRVSGRGELHLSVLIENMRREGYELAVSRPKVIYKEENGKKQEPFEQ
HHEEEECCCCCCCEEECCCCCEEHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCHHH
VTIDIEEQHQGAVMEALGIRKGEVKDMIPDGKGRTRLEYVIPSRGLIGFRNEFMTMTSGT
EEEEECCCCCCHHHHHHCCCCCCHHHCCCCCCCCEEEEEEECCCCCEEECCCEEEEECCC
GLLYSSFSHYDDVKPGEIGQRKNGVLISNATGKALAYALFGLQERGKLMIDHGVDVYEGQ
CCEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCEEECCE
IIGIHSRGNDLTVNCLQGKKLTNMRASGKDDAIVLTTPVRLSLEQALEFIDDDELVEVTP
EEEEEECCCCEEEEEECCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEECH
QSIRVRKRLLTENDRKRAGRTTTSTSTK
HHHHHHHHHHCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]