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The map label for this gene is mraY

Identifier: 126207503

GI number: 126207503

Start: 16962

End: 18044

Strand: Direct

Name: mraY

Synonym: APL_0015

Alternate gene names: 126207503

Gene position: 16962-18044 (Clockwise)

Preceding gene: 126207502

Following gene: 126207504

Centisome position: 0.75

GC content: 43.86

Gene sequence:

>1083_bases
ATGTTAGTTTGGCTTGCTGAGTATTTAGTCCAATACAATACGGCATTTAACGTTGTATCTTATATTACTTTCCGTGCGAT
TATGGCGTTGCTTACCGCAATGGGAATCGGTTTATGGATTGGTCCCGAAGTGATTCGTCGCTTACAGCTCTTAAAATTCG
GTCAAGAAGTGCGTAACGACGGTCCGGAAAGCCACTTTAAAAAACGCGGTACACCGACTATGGGCGGCATTATGATTTTA
ATCGCCATCGGCGTGAGTACTTTGCTTTGGGCGGATTTACGTAACAGCTATATTTGGTTTGTGCTGTTTGTGTTATTCGG
TTACGGTGCGGTTGGTTTTGTCGATGATTACTGGAAAATCAAACGCAAAAATACCGACGGTTTAATTGCGCGTTGGAAAT
ATTTCTGGTTGTCGGTGATTGCGCTGATTGCGGTATTCGGCATTTATGCTGTCGGTAAAGATACGGCGGCAACCCAATTA
GTGGTGCCGTTCTTTAAAGATGTGATGCCGCAGCTCGGTATTTTCTTTATCATTCTTTCTTATTTTGTGATTGTTGGTAC
GTCAAATGCGGTAAACCTAACAGACGGTTTAGACGGCTTAGCGATTGTACCGACCATTATGGTGGCATCGGCTTTTGCAT
TAATCGCCTGGGCGACCGGTAACTTCAATTTTGCACAATATTTACATATTCCGTTTGTTCCGAATGCCGGTGAATTAGTG
ATTCTATGTACTGCGATTGTCGGTGCCGGTTTAGGCTTCTTATGGTACAACACCTATCCGGCGCAAGTATTTATGGGCGA
TGTCGGTTCACTTTCATTAGGCGGTGCGTTAGGTACGATTGCGGTATTGGTTCGCCAAGAATTATTACTCGTGATTATGG
GCGGTGTATTCGTAGTGGAAGCCCTTTCGGTAATTTTACAAGTCGGTTCGTATAAACTTCGCCAAAAACGTATCTTCCGT
ATGGCGCCGATTCATCATCACTTCGAATTAAAAGGTTGGCCGGAGCCTCGTGTTATCGTGCGTTTCTGGATTATTACCTT
GATGCTTGTGTTAATCGGCTTAGTGACGTTAAAACTTCGTTAA

Upstream 100 bases:

>100_bases
TTAATGTTAAGGTAGATAGCGGTGCGAGCGTTTGCTCGTCGCTATTTAAATATAAATCGGGTGATTTACCCGCTTAAAAT
AATTTAACAAGGGTTTTGTT

Downstream 100 bases:

>100_bases
TCATAGGTGGGCTTGTCCCACCTTTTTCGCTTGCAAGCGGTCTGATTTATCCAAATTTTTACAAGTTATAAAGAGATTCA
ATTATGCAAAACCAATATAA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRNDGPESHFKKRGTPTMGGIMIL
IAIGVSTLLWADLRNSYIWFVLFVLFGYGAVGFVDDYWKIKRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQL
VVPFFKDVMPQLGIFFIILSYFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELV
ILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVEALSVILQVGSYKLRQKRIFR
MAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR

Sequences:

>Translated_360_residues
MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRNDGPESHFKKRGTPTMGGIMIL
IAIGVSTLLWADLRNSYIWFVLFVLFGYGAVGFVDDYWKIKRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQL
VVPFFKDVMPQLGIFFIILSYFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELV
ILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVEALSVILQVGSYKLRQKRIFR
MAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR
>Mature_360_residues
MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRNDGPESHFKKRGTPTMGGIMIL
IAIGVSTLLWADLRNSYIWFVLFVLFGYGAVGFVDDYWKIKRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQL
VVPFFKDVMPQLGIFFIILSYFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELV
ILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVEALSVILQVGSYKLRQKRIFR
MAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=360, Percent_Identity=77.7777777777778, Blast_Score=554, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_ACTP2 (A3MY87)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052728.1
- STRING:   A3MY87
- GeneID:   4849765
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0015
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   A3MY87
- ProtClustDB:   PRK00108
- BioCyc:   APLE416269:APL_0015-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 40093; Mature: 40093

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19f1312c)-; HASH(0x1b1f1dc0)-; HASH(0x1b1edde8)-; HASH(0x1b1ecadc)-; HASH(0x1b1edd10)-; HASH(0x1b1ede00)-; HASH(0x1b1eb5b0)-; HASH(0x1b1e75bc)-; HASH(0x1b1eb550)-; HASH(0x1b1f07e4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GPESHFKKRGTPTMGGIMILIAIGVSTLLWADLRNSYIWFVLFVLFGYGAVGFVDDYWKI
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQLVVPFFKDVMPQLGIFFIILS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEHEEEECCCCCCCCHH
ILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVE
HHHHHHHHCCHHHHHCCCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSVILQVGSYKLRQKRIFRMAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GPESHFKKRGTPTMGGIMILIAIGVSTLLWADLRNSYIWFVLFVLFGYGAVGFVDDYWKI
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQLVVPFFKDVMPQLGIFFIILS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEHEEEECCCCCCCCHH
ILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVE
HHHHHHHHCCHHHHHCCCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSVILQVGSYKLRQKRIFRMAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA