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The map label for this gene is guaB [H]

Identifier: 126175186

GI number: 126175186

Start: 3509377

End: 3510843

Strand: Reverse

Name: guaB [H]

Synonym: Sbal_2984

Alternate gene names: 126175186

Gene position: 3510843-3509377 (Counterclockwise)

Preceding gene: 126175188

Following gene: 126175185

Centisome position: 68.47

GC content: 47.92

Gene sequence:

>1467_bases
ATGCTACGTTTAATTAAAGAAGCGCTTACTTTTGACGATGTGTTGCTTGTTCCTGCGCATTCGACTGTACTCCCAAATAC
CGCCATTCTTAAAACTCGCCTGACCAATACCATAGAATTGAATATCCCACTTGTGTCTGCCGCTATGGACACAGTTACCG
AAGCTCGTCTTGCGATCGCTATGGCGCAGGAAGGCGGCTTAGGCTTTATTCATAAAAACATGAGCATTGAAAAACAAGCC
GAAGAAGTTCGTAAAGTAAAAATTTACGAAGCGGGCGTGGTTCAACAACCTGTGACTGTGACGCCATCAACGACTTTAGC
CGATCTGAAAGTGTTAACACTGAAGAATGGTTTTGCGGGTTATCCAGTGGTTAACGAAGCAAACGAGCTGGTCGGTATCA
TTACTGGCCGTGACGTACGTTTCGTGACGGATTGGAGCAAAACGGTAGAGGAAGTGATGACGCCTAAAGCGCGTTTAGTC
ACTGTTGCCGAAGGCACTAAATTAGATGAAGTGCAAAAATTGATGCACTCACACCGTATCGAAAAAGTCCTTGTGGTCGA
TGATAACTATAAGCTGAAAGGCCTCATCACAGTTAAAGACTTCGAAAAAGCCGAACGTAAACCTAACGCCTGTAAAGATG
AGTTAGGCCGTTTACGTGTTGGCGCTGCAGTTGGTGCGGGCGCAGGTAACGAGGAGCGTGTTGACGCACTCGTTAAAGCT
GGTGTTGACGTATTACTTATCGATTCTTCCCACGGACATTCAGAAGGCGTTTTACAACGCATTCGTGAAACTCGCGCTAA
ACATCCTGATTTGCAAATTATCGGTGGTAACGTTGCCACGGCTGAAGGCGCATTAGCGCTGGTCGAAGCGGGCGTTAACG
CAGTTAAAGTGGGCATTGGCCCTGGTTCTATCTGTACGACTCGTATCGTAACTGGTGTTGGCGTGCCACAAATCACAGCC
GTTTCAGATGCTGCCGCAGCCATGAAGAGCCTAGGTATTCCTGTTATTGCCGATGGTGGTATTCGTTTCTCTGGTGACTT
AGCCAAAGCATTAGCCGCGGGTGCATCTTGCATCATGGCGGGCTCAATGTTTGCGGGAACTGAGGAAGCGCCAGGCGAAA
CTGAACTTTATCAAGGCCGTGCGTATAAATCCTACCGTGGTATGGGGTCATTAGGCGCTATGTCTCAAGGCTCTTCTGAC
CGTTATTTCCAATCAGACAATGCTGCCGACAAGTTAGTCCCAGAAGGTGTTGAAGCGCGCGTGCCTTACAAAGGCAAGTT
GAAGGAAATCATCCATCAACATATGGGCGGTCTGCGTTCATGCATGGGCTTAACGGGTTGTGCCACCATTCTAGAACTGA
ATGAAAAAGCCCAATTTGTGAAAGTGACTTCAGCAGGCATGGGCGAGTCTCACGTGCACGATGTGACTATCACTAAAGAA
GCGCCGAACTATCGTTCAGGTTCTTAA

Upstream 100 bases:

>100_bases
GGATATTTGCTATTTTCCATTTACCAGTGCCGATATGCAAGGTATAATCCCGCCGCAATATTTCACCTCTAAATCCTACT
CAACTGGGGAGATGTTGCAT

Downstream 100 bases:

>100_bases
TCGTTTGATAAGAGGGGGCGGCAATAAGCCGCCCCTTTGTAAAGCGTGTGATCCAATACTCAAGGCTGGCCCTCGCCGCG
TTGAGCAATGTTAAAACAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSHRIEKVLVVDDNYKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKHPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAMKSLGIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGVEARVPYKGKLKEIIHQHMGGLRSCMGLTGCATILELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS

Sequences:

>Translated_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSHRIEKVLVVDDNYKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKHPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAMKSLGIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGVEARVPYKGKLKEIIHQHMGGLRSCMGLTGCATILELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS
>Mature_488_residues
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIAMAQEGGLGFIHKNMSIEKQA
EEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAGYPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLV
TVAEGTKLDEVQKLMHSHRIEKVLVVDDNYKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
GVDVLLIDSSHGHSEGVLQRIRETRAKHPDLQIIGGNVATAEGALALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAMKSLGIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYQGRAYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGVEARVPYKGKLKEIIHQHMGGLRSCMGLTGCATILELNEKAQFVKVTSAGMGESHVHDVTITKE
APNYRSGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=41.1504424778761, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=41.1504424778761, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=41.1504424778761, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=41.1504424778761, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.8340248962656, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=41.2556053811659, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=40.0442477876106, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=37.6106194690265, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=37.8048780487805, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541954, Length=276, Percent_Identity=35.1449275362319, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541952, Length=276, Percent_Identity=35.1449275362319, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541948, Length=276, Percent_Identity=35.1449275362319, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541956, Length=276, Percent_Identity=35.1449275362319, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=79.7131147540984, Blast_Score=735, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.1990950226244, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=37.4736842105263, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.3364928909953, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=35.7142857142857, Blast_Score=151, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=40.2892561983471, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=39.0946502057613, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.1656314699793, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.6432748538012, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=39.344262295082, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.1304347826087, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.1304347826087, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.6825396825397, Blast_Score=284, Evalue=1e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51760; Mature: 51760

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHEEHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCCHHCEEEEEEECCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLVTVAEGTKLDEVQKLMHSHRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
EKVLVVDDNYKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKHPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAMKSLGIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTEEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGVEAR
CCCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATILELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEC
APNYRSGS
CCCCCCCC
>Mature Secondary Structure
MLRLIKEALTFDDVLLVPAHSTVLPNTAILKTRLTNTIELNIPLVSAAMDTVTEARLAIA
CHHHHHHHCCCCCEEEEECCCCCCCCHHEEHEECCCEEEEECCHHHHHHHHHHHHHHEEE
MAQEGGLGFIHKNMSIEKQAEEVRKVKIYEAGVVQQPVTVTPSTTLADLKVLTLKNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCCHHCEEEEEEECCCCC
YPVVNEANELVGIITGRDVRFVTDWSKTVEEVMTPKARLVTVAEGTKLDEVQKLMHSHRI
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
EKVLVVDDNYKLKGLITVKDFEKAERKPNACKDELGRLRVGAAVGAGAGNEERVDALVKA
CEEEEECCCEEEEEEEEECCHHHHHCCCCHHHHHHCCEEECEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKHPDLQIIGGNVATAEGALALVEAGVNAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEECCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAMKSLGIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTEEAPGETELYQGRAYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGVEAR
CCCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
VPYKGKLKEIIHQHMGGLRSCMGLTGCATILELNEKAQFVKVTSAGMGESHVHDVTITKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEC
APNYRSGS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]