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The map label for this gene is guaA [H]

Identifier: 126175185

GI number: 126175185

Start: 3507679

End: 3509256

Strand: Reverse

Name: guaA [H]

Synonym: Sbal_2983

Alternate gene names: 126175185

Gene position: 3509256-3507679 (Counterclockwise)

Preceding gene: 126175186

Following gene: 126175184

Centisome position: 68.44

GC content: 48.54

Gene sequence:

>1578_bases
ATGAGCGATATTCATGAGCACAAGATACTGATCCTCGATTTTGGATCTCAGTACACTCAACTGATTGCCCGTCGTATCCG
TGAAATCGGTGTGTACTGTGAATTATGGGCTTGGGACGTAACAGAAGCCCAAATCCGCGAATTTGCCCCGAACGGTATTA
TTCTTGCTGGCGGACCTGAAAGTGTAACGGCTGAAAACTCGCCGCGTGCGCCTGAATACGTATTTACTGCGGGTGTGCCT
GTACTGGGCATTTGCTACGGCATGCAAACCATGTCTGAGCAGCTGGGCGGTAAAGTGATCCAAGGTGTGGGCGAAGGTGA
ATTCGGCTACGCTCAAATTGAAATGCTGACAGATTCGCTACTATTCAAAGGCATCGAAGACGCAGTTAACAGCGAAGGCA
AACCCTTACTCGACGTATGGATGAGCCACGGCGATAAAGTATCGGCCATTCCTGAAGGGTTTGTGGCGGTCGCTAAAACG
GACACTTGCCCATTTGCCGCTATGGCAAACGAAGAGAAGCAATTCTTCGGCGTACAGTTCCACCCTGAAGTGACCCACAC
TCGCCAAGGCATGCGGATGTTATCGCACTTTGCCTTAGACATTTGTGGTTGTGCGGCTAACTGGAAACCTTCCTCTATCA
TCGAAGATGCGATTGAGCGCTTGAAGAAGCAAATCGGCGATGATGAAGTGATTTTAGGGCTATCGGGCGGTGTCGATTCT
TCGGTTGTGGCTATGTTGCTGCACCGTGCTATCGGTAAAAAACTGACCTGCGTATTCGTTGATAACGGTTTATTGCGTTT
GAACGAAGCCGAGCAAGTGATGGAAATGTTTGGCGATCATTTTGGTCTGAACATTATTCATGTTGATGCGGAAAATCGCT
TCCTTGACGCGATGAAAGGCGAAGCCGATCCAGAAGCTAAGCGTAAGATCATCGGCCGTGTATTCGTGGAAATTTTCGAT
GAAGAATCGAAAAAATGCGCCAATGCAAAATGGTTAGCGCAAGGCACGATTTATCCAGACGTGATTGAATCTGCTGGCAG
CGCCACAGGTAAAGCACATGTGATCAAGTCGCACCATAACGTTGGCGGTTTGCCAGACGATATGGAACTGGGTTTAGTTG
AGCCACTGCGCGAATTGTTCAAAGATGAAGTGCGCAAAATTGGTCTTGAGTTAGGTCTGCCATACAACATGCTTTATCGT
CACCCGTTCCCAGGACCGGGTCTTGGTGTGCGTGTTTTAGGTGAAGTGAAGAAAGAATACTGTGACTTATTGCGCCGCGC
CGATGCTATCTTCATCGAAGAACTGCATAAAGCCGACCTGTACAATAAAGTCAGCCAAGCCTTTACCGTTTTCTTACCTG
TACGCTCAGTCGGTGTTATGGGTGATGGCCGTAAATATGATTGGGTTGTGTCACTGCGCGCCGTTGAAACCGTTGATTTT
ATGACGGCCCATTGGGCACATCTGCCCTATGATTTCTTAGGTCGCGTATCGAACCGCATCATCAACGAAGTCGATGGTAT
TTCCCGTGTGGTTTACGATATTTCTGGCAAGCCGCCAGCGACGATCGAATGGGAATAA

Upstream 100 bases:

>100_bases
GCAATAAGCCGCCCCTTTGTAAAGCGTGTGATCCAATACTCAAGGCTGGCCCTCGCCGCGTTGAGCAATGTTAAAACAAT
AGATGAGATAAAGGTTACCC

Downstream 100 bases:

>100_bases
GTTAATTATTTGAATTAACGATTAAAAGGCGCCTAGTGCGCCTTTTTTGTTGTTTGATGGATTAACTTAGGCTGAATGAC
TCAGTCGTGAAATATCTGTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFTAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTDSLLFKGIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMANEEKQFFGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAEQVMEMFGDHFGLNIIHVDAENRFLDAMKGEADPEAKRKIIGRVFVEIFD
EESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFTAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTDSLLFKGIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMANEEKQFFGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAEQVMEMFGDHFGLNIIHVDAENRFLDAMKGEADPEAKRKIIGRVFVEIFD
EESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
>Mature_524_residues
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTAENSPRAPEYVFTAGVPV
LGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTDSLLFKGIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTD
TCPFAAMANEEKQFFGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDSS
VVAMLLHRAIGKKLTCVFVDNGLLRLNEAEQVMEMFGDHFGLNIIHVDAENRFLDAMKGEADPEAKRKIIGRVFVEIFDE
ESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDFM
TAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=574, Percent_Identity=35.191637630662, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=82.0267686424474, Blast_Score=916, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=34.0241796200345, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=34.0241796200345, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=34.0241796200345, Blast_Score=281, Evalue=8e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=524, Percent_Identity=49.4274809160305, Blast_Score=529, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=35.4609929078014, Blast_Score=285, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58225; Mature: 58093

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCCCCEEEECCCC
SVTAENSPRAPEYVFTAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTDSL
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKGIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMANEEKQFFGVQF
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCEEEEECCCCCCHHHCCCCHHEECEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAEQVMEMFGDHFGLNIIHVDAENRFLDAMKG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEECCCCHHHHHHCC
EADPEAKRKIIGRVFVEIFDEESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCCCCEEEECCCC
SVTAENSPRAPEYVFTAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLTDSL
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKGIEDAVNSEGKPLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMANEEKQFFGVQF
HHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCEEEEECCCCCCHHHCCCCHHEECEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQIGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAEQVMEMFGDHFGLNIIHVDAENRFLDAMKG
HHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEECCCCHHHHHHCC
EADPEAKRKIIGRVFVEIFDEESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA