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The map label for this gene is ribE [H]

Identifier: 126174362

GI number: 126174362

Start: 2490847

End: 2491470

Strand: Direct

Name: ribE [H]

Synonym: Sbal_2145

Alternate gene names: 126174362

Gene position: 2490847-2491470 (Clockwise)

Preceding gene: 126174357

Following gene: 126174365

Centisome position: 48.58

GC content: 43.75

Gene sequence:

>624_bases
ATGTTTACAGGTATAGTTCAAGCCACCTGCGAGGTGGTTGCAATACATAAGAAAGATGGCCTAAATACCCTTGAGGTAGC
GTTCGAACCTGATTTGCATGAGGGACTTGCGATTGGTGCAAGTGTGGCAAATAACGGGGTATGTCTTACTGTGACTCAGG
TCGTTGATGATATGGTATTTTTCGACGTAGTGGAAGAGACCTTGCGACTGACGAATCTGGCTAATTTGTCTATAGGTCAA
AGCGTTAATGTTGAGCGTTCGTTAACTTTTGGTAGTGAGATTGGTGGTCACATTCTCTCTGGCCATATTCATACCAAGGC
TAAAGTCGTCGATATTAGCCATACAGAACAGCATTATGATCTGACACTGGGCATTGAATCTAAATGGATGGATTACATTT
TTTATAAAGGTTTTGTTGGCGTTAACGGCTGCAGCTTAACAGTAGGCGAGGTGAGTGACTCCGGCTTTAAGTTGCACTTA
ATTCCTGAAACCCTAAAGCTGACCAATTTAAGTCAGTATAAAGTGGGTGATGAACTCAATATTGAGATCGACAGCCAAAC
GCAAGTTATCGTCGACACTGTCGAGCGCGTGCTGGCCAGACGTTTTAACGAACAAGCCCGTTAG

Upstream 100 bases:

>100_bases
CCTGAGCGATTAGCACCGGCAGCGCCAATTGGATTAAACGTTTGGCTTGATAGCCTGAATTATTCATAAATACAGCCTTT
AACGATTAAGCGAGCAGAAA

Downstream 100 bases:

>100_bases
TTTCGTGACATCGCAGCCTTTAGTGTAATCTAGTTTAATAGATTTGCTCGTCGTCTGAATCGATATACAGCTCAACGGTA
CGTCTCAATTCGTCGATATG

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MFTGIVQATCEVVAIHKKDGLNTLEVAFEPDLHEGLAIGASVANNGVCLTVTQVVDDMVFFDVVEETLRLTNLANLSIGQ
SVNVERSLTFGSEIGGHILSGHIHTKAKVVDISHTEQHYDLTLGIESKWMDYIFYKGFVGVNGCSLTVGEVSDSGFKLHL
IPETLKLTNLSQYKVGDELNIEIDSQTQVIVDTVERVLARRFNEQAR

Sequences:

>Translated_207_residues
MFTGIVQATCEVVAIHKKDGLNTLEVAFEPDLHEGLAIGASVANNGVCLTVTQVVDDMVFFDVVEETLRLTNLANLSIGQ
SVNVERSLTFGSEIGGHILSGHIHTKAKVVDISHTEQHYDLTLGIESKWMDYIFYKGFVGVNGCSLTVGEVSDSGFKLHL
IPETLKLTNLSQYKVGDELNIEIDSQTQVIVDTVERVLARRFNEQAR
>Mature_207_residues
MFTGIVQATCEVVAIHKKDGLNTLEVAFEPDLHEGLAIGASVANNGVCLTVTQVVDDMVFFDVVEETLRLTNLANLSIGQ
SVNVERSLTFGSEIGGHILSGHIHTKAKVVDISHTEQHYDLTLGIESKWMDYIFYKGFVGVNGCSLTVGEVSDSGFKLHL
IPETLKLTNLSQYKVGDELNIEIDSQTQVIVDTVERVLARRFNEQAR

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=204, Percent_Identity=52.4509803921569, Blast_Score=207, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6319733, Length=203, Percent_Identity=30.0492610837438, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 22749; Mature: 22749

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIVQATCEVVAIHKKDGLNTLEVAFEPDLHEGLAIGASVANNGVCLTVTQVVDDMVF
CCCCHHCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEHHHHHHHHHH
FDVVEETLRLTNLANLSIGQSVNVERSLTFGSEIGGHILSGHIHTKAKVVDISHTEQHYD
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEECEEECEEEEEEECCCCCEEE
LTLGIESKWMDYIFYKGFVGVNGCSLTVGEVSDSGFKLHLIPETLKLTNLSQYKVGDELN
EEEEECHHHHHHHEEECCCCCCCCEEEEECCCCCCEEEEEECCEEEECCCCCEECCCEEE
IEIDSQTQVIVDTVERVLARRFNEQAR
EEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFTGIVQATCEVVAIHKKDGLNTLEVAFEPDLHEGLAIGASVANNGVCLTVTQVVDDMVF
CCCCHHCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEHHHHHHHHHH
FDVVEETLRLTNLANLSIGQSVNVERSLTFGSEIGGHILSGHIHTKAKVVDISHTEQHYD
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEECEEECEEEEEEECCCCCEEE
LTLGIESKWMDYIFYKGFVGVNGCSLTVGEVSDSGFKLHLIPETLKLTNLSQYKVGDELN
EEEEECHHHHHHHEEECCCCCCCCEEEEECCCCCCEEEEEECCEEEECCCCCEECCCEEE
IEIDSQTQVIVDTVERVLARRFNEQAR
EEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9022701; 9023191; 9097039; 9278503; 11377200 [H]