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The map label for this gene is hmrR [H]

Identifier: 126173742

GI number: 126173742

Start: 1748693

End: 1749193

Strand: Reverse

Name: hmrR [H]

Synonym: Sbal_1504

Alternate gene names: 126173742

Gene position: 1749193-1748693 (Counterclockwise)

Preceding gene: 126173745

Following gene: 126173732

Centisome position: 34.11

GC content: 48.1

Gene sequence:

>501_bases
ATGAAGATAGGCGAAGTGGCGAAACAAACGGGCTTGAGCGTTAAGAGTATCCGTTATTACCATGATATTGGCTTAGTGTG
CGGCGAGCGCAATGAGGCGGGTTATCGGGTTTACCGCCATCAAGATATTGAAGCGCTTAAGTTTGTGCATCAATGTCGCG
ACTTAGGTTTTAGCCTAGAAGATTGCAAATCCTTGCTTGGCCTTAAGGGCAATGAGAGCCGTAATGCCGAAGACGTCAAA
CAACTTACCCGTACTCACCTTGCCTATGTCGAAGAGCAAATCAATAAGTTGCAACAGCTTAGGGCGCAATTACAACACAT
GGTGACCCAATGCCAAGGCGGCGATCAGCCCCACTGCGCGATTATTGATAGCCTAAGCCATGAGGACAACGAGAGTAACG
ATACTGACGATGACAAATCCCAAAAAGACCAAAGCCTGCACGATGCAGGCTCTGAGTGTTGTTGTAAAGCCAGTCGCACT
AGCAACGGCCAAGAGTCATAA

Upstream 100 bases:

>100_bases
CCCATTGCGGGAGAGTCAAGGATGAATTTGCTCAATGTGATCACATCGACAATTAATTGCTGGGCGAAAAACCATTCAGT
TGCTCAAAGAAGAGGTCAAG

Downstream 100 bases:

>100_bases
CGGTAAATACTGCGTTATTGATTGCGGACTAAGGTCGGCTTTAACGCCGCAGCATTATCCAGTACCAATGTTGCCAACTT
ACCTGCAGGGGTAAAGTTAA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRDLGFSLEDCKSLLGLKGNESRNAEDVK
QLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESNDTDDDKSQKDQSLHDAGSECCCKASRT
SNGQES

Sequences:

>Translated_166_residues
MKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRDLGFSLEDCKSLLGLKGNESRNAEDVK
QLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESNDTDDDKSQKDQSLHDAGSECCCKASRT
SNGQES
>Mature_166_residues
MKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRDLGFSLEDCKSLLGLKGNESRNAEDVK
QLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESNDTDDDKSQKDQSLHDAGSECCCKASRT
SNGQES

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=40.9448818897638, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 18669; Mature: 18669

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRDLGFSLE
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHH
DCKSLLGLKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IIDSLSHEDNESNDTDDDKSQKDQSLHDAGSECCCKASRTSNGQES
HHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRDLGFSLE
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHH
DCKSLLGLKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IIDSLSHEDNESNDTDDDKSQKDQSLHDAGSECCCKASRTSNGQES
HHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]