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The map label for this gene is ispA [H]

Identifier: 126173596

GI number: 126173596

Start: 1558596

End: 1559477

Strand: Reverse

Name: ispA [H]

Synonym: Sbal_1358

Alternate gene names: 126173596

Gene position: 1559477-1558596 (Counterclockwise)

Preceding gene: 126173597

Following gene: 126173595

Centisome position: 30.41

GC content: 47.39

Gene sequence:

>882_bases
GTGTTAGTCAGTGCCATTCAAGAATATCAACAACGGGTTGATAATCAATTAAAACAGCGTCTTAGTACGCTTGAACATAC
CGCACCCCAATTAAAAGCCGCCATGACTTACGGCGCCTTATTAGGTGGTAAACGCATTCGACCTTTCCTTGTATACAGTG
TCGGACGCATGTTTGGGGTCGAGCTCGAAAAATTAGATGCTTGCGCCGCAGCCATTGAATGTATCCATGCTTATTCATTG
ATCCACGACGATTTACCCGCCATGGATGATGATGAGCTGCGCCGTGGTCAGCCCACAGTGCATATCGCTTTTGATGAAGC
GACCGCCATTTTAGCTGGGGATGCACTGCAGACCTTAGCCTTTGAAATTGTCACCGAAGCGGTACCTGGGATCAGCAGCG
AGCAACATATCGCTATGGTCAGAGTATTAGCAAAAGCCTCAGGTTATCGTGGCATGTGTGGCGGCCAAGCGATAGACTTA
GCCTCAACCGATAAACATATTGATCTTAAAGCATTAACTCAGTTACATAATATGAAAACGGGCGCCCTTATCAGTTGCGC
CGTTGAGTTAGCATTAATCGCCGCAAACGCGCCAAAAGATCAGTATGCTGCTATGATGGATTTTGCCCGTGCGGTCGGAC
TCGCCTTCCAAGTACAAGACGATATCCTCGACATCGTAGCCACCACCGAAGAACTCGGTAAGCCGCAAGGCTCTGATACT
GAATCGAATAAGAGTACGTTTCCACAACTACTTGGACTACAAGGTGCACAAGACACCGCCAAACAACTGATCCAAGAGGC
ACTATCAGCGCTGGCTAAATTGCCATACAATAGCCAGTTAATTGCAGACTTCGCCCGCTATATCATTGAGCGAAGAATAT
AA

Upstream 100 bases:

>100_bases
GCCAAGCAAAACTCGAACAAGCCCAACAAAAAGTGGCCATTTTACTGAAACAAGATGAAAATGCGCCCCTATCCCCCTAT
GCCGTTGAGGGCGAATAAGC

Downstream 100 bases:

>100_bases
TAAGAGTCGAAGTATCTCGCTATGAGTTTGGACATTTCTCAGTTTCCCGTGTTGGCACAGGCCAACACCCCCAATGAACT
CCGCCAGCTTCCTCAGGCAC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLVSAIQEYQQRVDNQLKQRLSTLEHTAPQLKAAMTYGALLGGKRIRPFLVYSVGRMFGVELEKLDACAAAIECIHAYSL
IHDDLPAMDDDELRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRVLAKASGYRGMCGGQAIDL
ASTDKHIDLKALTQLHNMKTGALISCAVELALIAANAPKDQYAAMMDFARAVGLAFQVQDDILDIVATTEELGKPQGSDT
ESNKSTFPQLLGLQGAQDTAKQLIQEALSALAKLPYNSQLIADFARYIIERRI

Sequences:

>Translated_293_residues
MLVSAIQEYQQRVDNQLKQRLSTLEHTAPQLKAAMTYGALLGGKRIRPFLVYSVGRMFGVELEKLDACAAAIECIHAYSL
IHDDLPAMDDDELRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRVLAKASGYRGMCGGQAIDL
ASTDKHIDLKALTQLHNMKTGALISCAVELALIAANAPKDQYAAMMDFARAVGLAFQVQDDILDIVATTEELGKPQGSDT
ESNKSTFPQLLGLQGAQDTAKQLIQEALSALAKLPYNSQLIADFARYIIERRI
>Mature_293_residues
MLVSAIQEYQQRVDNQLKQRLSTLEHTAPQLKAAMTYGALLGGKRIRPFLVYSVGRMFGVELEKLDACAAAIECIHAYSL
IHDDLPAMDDDELRRGQPTVHIAFDEATAILAGDALQTLAFEIVTEAVPGISSEQHIAMVRVLAKASGYRGMCGGQAIDL
ASTDKHIDLKALTQLHNMKTGALISCAVELALIAANAPKDQYAAMMDFARAVGLAFQVQDDILDIVATTEELGKPQGSDT
ESNKSTFPQLLGLQGAQDTAKQLIQEALSALAKLPYNSQLIADFARYIIERRI

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=220, Percent_Identity=26.3636363636364, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786623, Length=262, Percent_Identity=56.4885496183206, Blast_Score=257, Evalue=5e-70,
Organism=Escherichia coli, GI1789578, Length=228, Percent_Identity=31.5789473684211, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17505681, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651612, Length=238, Percent_Identity=26.4705882352941, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31798; Mature: 31798

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSAIQEYQQRVDNQLKQRLSTLEHTAPQLKAAMTYGALLGGKRIRPFLVYSVGRMFGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ELEKLDACAAAIECIHAYSLIHDDLPAMDDDELRRGQPTVHIAFDEATAILAGDALQTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
FEIVTEAVPGISSEQHIAMVRVLAKASGYRGMCGGQAIDLASTDKHIDLKALTQLHNMKT
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCC
GALISCAVELALIAANAPKDQYAAMMDFARAVGLAFQVQDDILDIVATTEELGKPQGSDT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESNKSTFPQLLGLQGAQDTAKQLIQEALSALAKLPYNSQLIADFARYIIERRI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVSAIQEYQQRVDNQLKQRLSTLEHTAPQLKAAMTYGALLGGKRIRPFLVYSVGRMFGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
ELEKLDACAAAIECIHAYSLIHDDLPAMDDDELRRGQPTVHIAFDEATAILAGDALQTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
FEIVTEAVPGISSEQHIAMVRVLAKASGYRGMCGGQAIDLASTDKHIDLKALTQLHNMKT
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCC
GALISCAVELALIAANAPKDQYAAMMDFARAVGLAFQVQDDILDIVATTEELGKPQGSDT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESNKSTFPQLLGLQGAQDTAKQLIQEALSALAKLPYNSQLIADFARYIIERRI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]