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The map label for this gene is dxs [H]

Identifier: 126173595

GI number: 126173595

Start: 1556706

End: 1558574

Strand: Reverse

Name: dxs [H]

Synonym: Sbal_1357

Alternate gene names: 126173595

Gene position: 1558574-1556706 (Counterclockwise)

Preceding gene: 126173596

Following gene: 126173593

Centisome position: 30.4

GC content: 50.67

Gene sequence:

>1869_bases
ATGAGTTTGGACATTTCTCAGTTTCCCGTGTTGGCACAGGCCAACACCCCCAATGAACTCCGCCAGCTTCCTCAGGCACT
TTTACCACAAGTAGCCGACGAACTGCGCGAGTTCCTTCTTAAGTCTGTTGGCATATCCAGCGGACATTTTGCCTCTGGGC
TCGGCACAGTGGAACTCACTGTTGCGCTGCACTATGTCTACAACACCCCTTTTGATCGGCTGATTTGGGATGTGGGCCAT
CAGGCTTATCCCCATAAAATTCTCACGGGTCGTCGTGACAAGATGCACACCATTAGACAAAAAGATGGCTTGCATCCTTT
CCCATGGCGTGAAGAAAGTGAATACGACACTTTCAGCGTTGGGCATTCAGGCACGTCTATCAGCGCCGCACTGGCGATGG
CGATTGCCGCAGAAAAAGAGCAAGCGGGTCGTAAAGTCGTTGCCGTGATCGGCGATGGCGCTATGACAGGCGGCATGGTG
TTTGAAGCCATGAACCACGCTGGCGACTTGCACAATGACATGCTCGTGGTGTTGAACGACAACGAAATGTCGATCTCTGA
AAATGTCGGCGCCCTCAATAACCATTTAGCACAACTGATGTCAGGCCGTTTCTACACTACGCTGCGCGAAGGCGGCAAAA
AAGTGTTGAAAGGCATGCCCGTCATCAAAGAAATGGCCAAGCGCACTGAGGAACACCTCAAAGGCATGGTCGTTCCTGGC
ACCCTATTTGAAGAGTTAGGTTTCAACTATATCGGTCCTATCGACGGCCACGATGTTGATGCTCTGGTCGAGACCATGCG
TAATATGCGCAATCTTAAAGGTCCACAGGTGCTGCACATCATGACGAAGAAAGGTCGTGGTTATGAACCTGCTGAAAAAG
ATCCTATCGGTTGGCATGCGGTGCCTAAGTTTGACCCGTCGCTGTTTAAAAAGCCGACTACCAAACCCGGTTTGCCGACC
TTTTCTCAAGTCTTTGGTAAATGGTTATGCGACATTGCCGAGCAAGATGAGAAAGTATTAGCGATTACGCCTGCGATGCG
CGAAGGCTCTGGCATGGTGGAGTTTTCCCAGCGTTTCCCGAAACAATATTTCGATGCGGCGATTGCCGAGCAGCATGCCG
TCACCCTATCAGCAGGTTTTGCCTGTGAAGGCTTTAAGCCTGTGGTGGCGATTTACTCGACCTTCCTGCAACGCGCCTAC
GATCAGCTAATTCATGATGTGGCGCTGCAAAAATTGCCAGTATTGTTTGCTATTGACCGTGGCGGTATCGTTGGTGCCGA
TGGTCCAACTCACCAAGGTGCATTCGATTTAAGCTTTATGCGTTGCATCCCCAACATGGTGATCATGGCGCCGTCGGACG
AAAATGAATGTCGTCAAATGCTCTACACAGGCTATTGCTATGATGCAGGCCCAAGTGCAGTGCGTTATCCAAGGGGCTGT
GCCACGGGAGCAACGCAAGTCGAAGCGATGACGGCATTACCGATTGGTAAAGGCGTGATCAAACGTGTGGGTAAGCGCAT
TGCCATACTCAACTTTGGCACCTTGTTAGCGTCGGCGTTAACCGCTGCCGAAAGCTTAGATGCAACGGTTGTCGATATGC
GCTTTGTGAAACCACTTGATGTTGATTTGGTCAAAGAGATGGCGCAAACCCACGAAGTACTCGTCACAGTGGAAGAAAAC
GCCATTATGGGCGGCGCAGGTGCTGGCGTGCTTGAGCAGCTTCAAAAGCTGCGAATGCCTAAAGCCGTGCTTCAAATTGG
TTTGCCAGATGAATTCATCAAACATGGCTCGCCAGAGGAAGTTACCCATGATTTGCAACTGGATGCCGAAGGTATACTGG
CGCAAATCAATGCTTATCTAGCACAATAA

Upstream 100 bases:

>100_bases
ATCAGCGCTGGCTAAATTGCCATACAATAGCCAGTTAATTGCAGACTTCGCCCGCTATATCATTGAGCGAAGAATATAAT
AAGAGTCGAAGTATCTCGCT

Downstream 100 bases:

>100_bases
ATAGCTCAATAGTTGGCGTAATAGTTAGAACTTACTTATCTCGGTAAGGTGCTCAGTCCTACCAATACAAATTCTGCACA
TATCACCGCCCATAAAAAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSVGHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSLFKKPTTKPGLPT
FSQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAY
DQLIHDVALQKLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGC
ATGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHEVLVTVEEN
AIMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ

Sequences:

>Translated_622_residues
MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSVGHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSLFKKPTTKPGLPT
FSQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAY
DQLIHDVALQKLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGC
ATGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHEVLVTVEEN
AIMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ
>Mature_621_residues
SLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQ
AYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSVGHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMVF
EAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPGT
LFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSLFKKPTTKPGLPTF
SQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAYD
QLIHDVALQKLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGCA
TGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHEVLVTVEENA
IMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=625, Percent_Identity=23.84, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=71.9806763285024, Blast_Score=939, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=561, Percent_Identity=23.1729055258467, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666278, Length=621, Percent_Identity=24.4766505636071, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551847, Length=528, Percent_Identity=24.4318181818182, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI45550715, Length=528, Percent_Identity=24.4318181818182, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24645119, Length=528, Percent_Identity=24.4318181818182, Blast_Score=102, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68052; Mature: 67921

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELT
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSLFKKPTTKPGLPTFSQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAYDQLIHDVALQKLPVLFAIDR
HHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGC
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCC
ATGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLD
CCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEHHHHCCCCC
VDLVKEMAQTHEVLVTVEENAIMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEE
HHHHHHHHHHCCEEEEEECCEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCHHH
VTHDLQLDAEGILAQINAYLAQ
HHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGISSGHFASGLGTVELT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKDGLHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAIAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSLFKKPTTKPGLPTFSQVFGKWLCDIAEQDEKVLAITPAMREGSGMVEFSQRFP
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLSAGFACEGFKPVVAIYSTFLQRAYDQLIHDVALQKLPVLFAIDR
HHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGC
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCC
ATGATQVEAMTALPIGKGVIKRVGKRIAILNFGTLLASALTAAESLDATVVDMRFVKPLD
CCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCEEHHHHCCCCC
VDLVKEMAQTHEVLVTVEENAIMGGAGAGVLEQLQKLRMPKAVLQIGLPDEFIKHGSPEE
HHHHHHHHHHCCEEEEEECCEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCHHH
VTHDLQLDAEGILAQINAYLAQ
HHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA